Abstract B071: Enhanced IL-12 production and T cell stimulation ability by dendritic cells matured in presence of GMP-grade Toll-like receptor ligands and IFN-γ

2016 ◽  
Author(s):  
Lars Adamson ◽  
Dhifaf Sarhan ◽  
Bhavesh Choudhary ◽  
Jeroen Melief ◽  
Maria Nyström ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Toll Like Receptor ◽  
Receptor Ligands ◽  
Cell Stimulation ◽  
T Cell Stimulation ◽  
Ifn Γ

Restoration of Abated T Cell Stimulation Activity of Mature Dendritic Cells

2001 ◽  
Vol 285 (3) ◽  
pp. 594-597 ◽  
Author(s):  
Eugene W. Holowachuk ◽  
Mary S. Ruhoff
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Stimulation ◽  
T Cell Stimulation

scholarly journals Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity

2005 ◽  
Vol 78 (2) ◽  
pp. 319-324 ◽  
Author(s):  
Jonathan K. H. Tan ◽  
Helen C. O’Neill
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Stimulation ◽  
T Cell Stimulation

scholarly journals Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells

Blood ◽  
2010 ◽  
Vol 116 (26) ◽  
pp. 5875-5884 ◽  
Author(s):  
Hideaki Tanizaki ◽  
Gyohei Egawa ◽  
Kayo Inaba ◽  
Tetsuya Honda ◽  
Saeko Nakajima ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
T Cell ◽  
Immune Responses ◽  
Lymph Nodes ◽  
Actin Polymerization ◽  
Cell Stimulation ◽  
T Cell Stimulation ◽  
Acquired Immune Responses

Abstract Dendritic cells (DCs) are essential for the initiation of acquired immune responses through antigen acquisition, migration, maturation, and T-cell stimulation. One of the critical mechanisms in this response is the process actin nucleation and polymerization, which is mediated by several groups of proteins, including mammalian Diaphanous-related formins (mDia). However, the role of mDia in DCs remains unknown. Herein, we examined the role of mDia1 (one of the isoforms of mDia) in DCs. Although the proliferation and maturation of bone marrow-derived DCs were comparable between control C57BL/6 and mDia1-deficient (mDia1−/−) mice, adhesion and spreading to cellular matrix were impaired in mDia1−/− bone marrow–derived DCs. In addition, fluorescein isothiocyanate-induced cutaneous DC migration to draining lymph nodes in vivo and invasive migration and directional migration to CCL21 in vitro were suppressed in mDia1−/− DCs. Moreover, sustained T-cell interaction and T-cell stimulation in lymph nodes were impaired by mDia1 deficiency. Consistent with this, the DC-dependent delayed hypersensitivity response was attenuated by mDia1-deficient DCs. These results suggest that actin polymerization, which is mediated by mDia1, is essential for several aspects of DC-initiated acquired immune responses.

scholarly journals Dendritic cells are susceptible to infection with wild-type adenovirus, inducing a differentiation arrest in precursor cells and inducing a strong T-cell stimulation

2009 ◽  
Vol 91 (5) ◽  
pp. 1150-1154 ◽  
Author(s):  
T. Kessler ◽  
K. Hamprecht ◽  
T. Feuchtinger ◽  
G. Jahn
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Precursor Cells ◽  
Wild Type ◽  
Cell Stimulation ◽  
T Cell Stimulation

scholarly journals Selected Toll-like Receptor Ligands and Viruses Promote Helper-Independent Cytotoxic T Cell Priming by Upregulating CD40L on Dendritic Cells

Immunity ◽  
2009 ◽  
Vol 30 (2) ◽  
pp. 218-227 ◽  
Author(s):  
Susan Johnson ◽  
Yifan Zhan ◽  
Robyn M. Sutherland ◽  
Adele M. Mount ◽  
Sammy Bedoui ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cytotoxic T Cell ◽  
Toll Like Receptor ◽  
Receptor Ligands ◽  
T Cell Priming

scholarly journals Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2005 ◽  
Vol 202 (7) ◽  
pp. 885-891 ◽  
Author(s):  
Kuibeom Ko ◽  
Sayuri Yamazaki ◽  
Kyoko Nakamura ◽  
Tomohisa Nishioka ◽  
Keiji Hirota ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Tumor Immunity ◽  
Cd8 T Cells ◽  
Effector T Cells ◽  
Tumor Rejection ◽  
Cell Stimulation ◽  
T Cell Stimulation ◽  
Ifn Γ ◽  
Advanced Tumors

T cell stimulation via glucocorticoid-induced tumor necrosis factor receptor family–related protein (GITR) can evoke effective tumor immunity. A single administration of agonistic anti-GITR monoclonal antibody (mAb) to tumor-bearing mice intravenously or directly into tumors provoked potent tumor-specific immunity and eradicated established tumors without eliciting overt autoimmune disease. A large number of CD4+ and CD8+ T cells, including interferon (IFN)-γ–secreting cells, infiltrated regressing tumors. Tumor-specific IFN-γ–secreting CD4+ and CD8+ T cells also increased in the spleen. The treatment led to tumor rejection in IFN-γ–intact mice but not IFN-γ–deficient mice. Furthermore, coadministration of anti-GITR and anti–CTLA-4 mAbs had a synergistic effect, leading to eradication of more advanced tumors. In contrast, coadministration of anti-CD25 and anti-GITR mAbs was less effective than anti-GITR treatment alone, because anti-CD25 depleted both CD25+-activated effector T cells and CD25+CD4+ naturally occurring regulatory T (T reg) cells. Importantly, CD4+ T cells expressing the T reg–specific transcription factor Foxp3 predominantly infiltrated growing tumors in control mice, indicating that tumor-infiltrating natural Foxp3+CD25+CD4+ T reg cells may hamper the development of effective tumor immunity. Taken together, T cell stimulation through GITR attenuates T reg–mediated suppression or enhances tumor-killing by CD4+ and CD8+ effector T cells, including those secreting IFN-γ, or both. Agonistic anti-GITR mAb is therefore instrumental in treating advanced cancers.

scholarly journals CD83 Knockdown in Monocyte-Derived Dendritic Cells by Small Interfering RNA Leads to a Diminished T Cell Stimulation

2007 ◽  
Vol 178 (9) ◽  
pp. 5454-5464 ◽  
Author(s):  
Alexander T. Prechtel ◽  
Nadine M. Turza ◽  
Alexandros A. Theodoridis ◽  
Alexander Steinkasserer
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Small Interfering Rna ◽  
Cell Stimulation ◽  
T Cell Stimulation ◽  
Interfering Rna

scholarly journals Innate IFN-γ Is Essential for Programmed Death Ligand-1–Mediated T Cell Stimulation followingListeria monocytogenesInfection

2012 ◽  
Vol 189 (2) ◽  
pp. 876-884 ◽  
Author(s):  
Jared H. Rowe ◽  
James M. Ertelt ◽  
Sing Sing Way
Keyword(s):  
T Cell ◽  
Cell Stimulation ◽  
Programmed Death Ligand 1 ◽  
T Cell Stimulation ◽  
Programmed Death ◽  
Ifn Γ

Dendritic cells fused with human cancer cells: morphology, antigen expression, and T cell stimulation

2004 ◽  
Vol 113 (3) ◽  
pp. 261-269 ◽  
Author(s):  
Shigeo Koido ◽  
Masaya Ohana ◽  
Chunlei Liu ◽  
Najmosama Nikrui ◽  
John Durfee ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cancer Cells ◽  
Human Cancer ◽  
Antigen Expression ◽  
Cell Stimulation ◽  
Human Cancer Cells ◽  
T Cell Stimulation
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