Zein as a water insoluble excipient for spray dry encapsulation of hydrophilic bioactives

2020 ◽  
Vol 283 ◽  
pp. 110054 ◽  
Author(s):  
Jerome Jie Long Wong ◽  
Adeline Ik Chian Wong ◽  
Yunyun Xu ◽  
Oni Yuliarti
Keyword(s):  
Clay Minerals ◽  
1999 ◽  
Vol 34 (1) ◽  
pp. 127-135 ◽  
Author(s):  
S. Hillier

AbstractThe construction and operation of a spray drier is described where the spray is produced using an air brush, essentially a miniature spray gun. The spray-dried products consist of spheres 50–60 µm in diameter and typical product recoveries are 80%, a marked improvement over simple two-nozzle systems. The spray-dried samples are easy to load into XRD powder holders and present a smooth surface and relatively constant bulk density to the X-ray beam. Problems of preferred orientation are effectively eliminated and the resulting X-ray powder patterns are completely reproducible by different operators.


1996 ◽  
Vol 19 (6) ◽  
pp. 550-552
Author(s):  
Akinori Meazawa ◽  
Harunobu Suzuki ◽  
Tadachika Seno ◽  
Shigeo Uchida
Keyword(s):  

MRS Advances ◽  
2016 ◽  
Vol 1 (18) ◽  
pp. 1277-1282
Author(s):  
Shota Ishii ◽  
Tomoaki Sugiyama ◽  
Jeffrey S. Cross ◽  
Toshiyuki Ikoma

ABSTRACTCalcium phosphate cements show self-hardening reaction upon mixing with liquids to form calcium-deficient hydroxyapatite (CDHA) or dicalcium phosphate dihydrate. The effects of particle sizes, crystallinities, and natural polymers such as tilapia scale collagen (Col) and hyaluronic acid as a dispersant on the mechanical properties of alpha tricalcium phosphate (TCP) cements mixed with citric acid (CA) as an additive were investigated. Three types of alpha TCP particles were fabricated with spray-dry (SD; 14 μm), freeze-dry (FD; 45 μm), and cold isostatic press (CIP; 134 μm) methods, followed by sintering at 1300°C and ground/crushed. The amounts of Ca dissolution from these particles were in the order of SD > FD > CIP. The CA liquid was added to the powders of SD-FD or SD-CIP, and kneaded under different liquid/powder ratios. The cements containing CIP particles showed lower compressive strength at 22.9 ± 1.5 MPa than those containing FD particles at 28.3 ± 2.5 MPa, even though the apparent densities of the cements containing CIP material was higher. Although the packing density of powders is an important factor on the mechanical properties of cements, the dissolution of Ca ion has a greater impact on the mechanical properties. The addition of Col into the cements increased the mechanical properties at 33.6 ± 2.5 MPa at 1 day to enhance the re-precipitation of CDHA.


Author(s):  
Amila Amila ◽  
Cepy Hadiansyah ◽  
Yukeu Fazriah ◽  
Fitrianti Darusman ◽  
Indra Topik
Keyword(s):  

Berbagai penelitian membuktikan bahwa likopen dapat menurunkan resiko berbagai penyakit seperti gangguan kardiovaskular, diabetes,  hiperkolesterolemia dan kanker. Akan tetapi, likopen sangat mudah mengalami reaksi isomerisasi dan oksidasi selama proses pengolahan maupun penyimpanan karena memiliki banyak ikatan tak jenuh, sehingga aktivitasnya jadi menurun. Oleh sebab itu, untuk meningkatkan stabilitas likopen dilakukan teknik mikroenkapsulasi. Tujuan dari penelitan ini adalah mengetahui pengaruh jenis penyalut terhadap stabilitas likopen hasil mikroenkapsulsi dengan metode spray dry. Jenis penyalut yang digunakan adalah Hidroksi propil β-siklodekstrin (M1) dan kombinasi Whey protein-Maltodekstrin (M2). Mikrokapsul yang diperoleh dievaluasi meliputi Efisiensi Enkapsulasi (EE), kandungan lembab dan sifat organolpetis, lalu dilanjutkan dengan pengujian stabilitas pada suhu kamar dengan dua kondisi yang berbeda yaitu  terpapar cahaya dan tidak terpapar cahaya. Hasil evaluasi menunjukan nilai EE untuk M1 dan M2 adalah 7,6 % dan 8,2 %, Kandungan lembab 5,4 % (M1) dan 5,09% (M2), dan semua formula menunjukan sifat organolpetis yang hampir sama yaitu berbentuk serbuk berwarna jingga dengan bau khas. Hasil uji stablitas menunjukan bahwa baik M1 maupun M2 tidak mengalami penurunan kadar selama 4 minggu penyimpanan pada tempat tidak terpapar cahaya, sedangkan pembanding dalam bentuk serbuk likopen bebas mengalami penurunan kadar sebesar 40,9%. Pada penyimpanan terpapar cahaya M1 dan M2 mengalami penurunan kadar masing masing sebesar 48,7% dan 43,37%, sedangkan pembanding 96,75%. Kesimpulan yang didapat adalah bahwa kedua jenis penyalut tidak mempengaruhi stabilitas likopen dalam bentuk mikrokapsul. 


2001 ◽  
Vol 73 (6) ◽  
pp. 601-601
Author(s):  
Jens Stein ◽  
Matthias Kind ◽  
Ernst-Ulrich Schlünder
Keyword(s):  

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