Hepatitis C virus core protein exerts an inhibitory effect on suppressor of cytokine signaling (SOCS)-1 gene expression

2005 ◽  
Vol 43 (5) ◽  
pp. 757-763 ◽  
Author(s):  
Hideyuki Miyoshi ◽  
Hajime Fujie ◽  
Yoshizumi Shintani ◽  
Takeya Tsutsumi ◽  
Seiko Shinzawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Inhibitory Effect ◽  
Cytokine Signaling ◽  
Suppressor Of Cytokine Signaling ◽  
Virus Core

scholarly journals Inhibitory effect of miR-125b on hepatitis C virus core protein-induced TLR2/MyD88 signaling in THP-1 cells

2016 ◽  
Vol 22 (17) ◽  
pp. 4354 ◽  
Author(s):  
Cheng Peng ◽  
Hua Wang ◽  
Wen-Jing Zhang ◽  
Sheng-Hua Jie ◽  
Qiao-Xia Tong ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Inhibitory Effect ◽  
Virus Core ◽  
Myd88 Signaling

scholarly journals Mechanisms for Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatitis C Virus Core Protein

2002 ◽  
Vol 278 (1) ◽  
pp. 591-607 ◽  
Author(s):  
Shiow-Yi Chen ◽  
Chih-Fei Kao ◽  
Chun-Ming Chen ◽  
Chwen-Ming Shih ◽  
Ming-Jen Hsu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Core Protein ◽  
Virus Gene ◽  
Virus Gene Expression ◽  
Virus Core ◽  
B Virus

scholarly journals Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation

2002 ◽  
Vol 196 (5) ◽  
pp. 641-653 ◽  
Author(s):  
Takafumi Yoshida ◽  
Toshikatsu Hanada ◽  
Takeshi Tokuhisa ◽  
Ken-ichiro Kosai ◽  
Michio Sata ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Human Tumor ◽  
Cellular Transformation ◽  
Cytokine Signaling ◽  
Virus Core ◽  
Hcv Core Protein ◽  
Transformed Cell Lines ◽  
Nih 3T3

The signal transducer and activator of transcription (STAT) family proteins are transcription factors critical in mediating cytokine signaling. Among them, STAT3 is often constitutively phosphorylated and activated in human cancers and in transformed cell lines and is implicated in tumorigenesis. However, cause of the persistent activation of STAT3 in human tumor cells is largely unknown. The hepatitis C virus (HCV) is a major etiological agent of non-A and non-B hepatitis, and chronic infection by HCV is associated with development of liver cirrhosis and hepatocellular carcinoma. HCV core protein is proposed to be responsible for the virus-induced transformation. We now report that HCV core protein directly interacts with and activates STAT3 through phosphorylation of the critical tyrosine residue. Activation of STAT3 by the HCV core in NIH-3T3 cells resulted in rapid proliferation and up-regulation of Bcl-XL and cyclin-D1. Additional expression of STAT3 in HCV core-expressing cells resulted in anchorage-independent growth and tumorigenesis. We propose that the HCV core protein cooperates with STAT3, which leads to cellular transformation.

Effects of hepatitis C virus on suppressor of cytokine signaling mRNA levels: Comparison between different genotypes and core protein sequence analysis

2011 ◽  
Vol 83 (6) ◽  
pp. 1005-1015 ◽  
Author(s):  
Stéphanie Pascarella ◽  
Sophie Clément ◽  
Kévin Guilloux ◽  
Stéphanie Conzelmann ◽  
François Penin ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sequence Analysis ◽  
Protein Sequence ◽  
Core Protein ◽  
Cytokine Signaling ◽  
Mrna Levels ◽  
Protein Sequence Analysis ◽  
Suppressor Of Cytokine Signaling

scholarly journals Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein

2002 ◽  
Vol 122 (2) ◽  
pp. 366-375 ◽  
Author(s):  
Michiari Okuda ◽  
Kui Li ◽  
Michael R. Beard ◽  
Lori A. Showalter ◽  
Frank Scholle ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Antioxidant Gene ◽  
Mitochondrial Injury ◽  
Virus Core ◽  
Antioxidant Gene Expression

Biosynthesis and biochemical properties of the hepatitis C virus core protein.

1994 ◽  
Vol 68 (6) ◽  
pp. 3631-3641 ◽  
Author(s):  
E Santolini ◽  
G Migliaccio ◽  
N La Monica
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Biochemical Properties ◽  
Virus Core
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