Long-term outcomes and predictive ability of non-invasive scoring systems in patients with non-alcoholic fatty liver disease

2021 ◽  
Author(s):  
Ramy Younes ◽  
Gian Paolo Caviglia ◽  
Olivier Govaere ◽  
Chiara Rosso ◽  
Angelo Armandi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Predictive Ability ◽  
Scoring Systems ◽  
Long Term Outcomes ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease with and without metabolic syndrome: Different long-term outcomes

Metabolism ◽  
2017 ◽  
Vol 66 ◽  
pp. 55-63 ◽  
Author(s):  
Aki Juhani Käräjämäki ◽  
Risto Bloigu ◽  
Heikki Kauma ◽  
Y. Antero Kesäniemi ◽  
Olli-Pekka Koivurova ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Long Term Outcomes ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals A188 COMPARING THE PERFORMANCE OF FIBROSIS-4 (FIB-4) AND NON-ALCOHOLIC FATTY LIVER DISEASE FIBROSIS SCORE (NFS) WITH FIBROSCAN SCORES IN NON-ALCOHOLIC FATTY LIVER DISEASE

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 59-60
Author(s):  
B D Cox ◽  
R Trasolini ◽  
C Galts ◽  
E M Yoshida ◽  
V Marquez
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Fatty Liver Disease ◽  
Scoring Systems ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease ◽  
Rule Out

Abstract Background With the rates of non-alcoholic fatty liver disease (NAFLD) on the rise, the necessity of identifying patients at risk of cirrhosis and its complications is becoming ever more important. Liver biopsy remains the gold standard for assessing fibrosis, although the costs, risks, and availability prohibit its widespread use for at-risk patients. Fibroscan has proven to be a non-invasive and accurate way of assessing fibrosis, although the availability of this modality is often limited in the primary care setting. The Fibrosis-4 (FIB-4) and Non-Alcoholic Fatty Liver Disease Fibrosis Score (NFS) are scoring systems which incorporate commonly measured lab parameters and BMI to predict fibrosis. In this study, we compared FIB-4 and NFS values to fibroscan scores to assess the accuracy of these inexpensive and readily available scoring systems for detecting fibrosis. Aims The aim of this study was to determine if non-invasive and inexpensive scoring systems (FIB-4 and NFS) can be used to rule out fibrosis in non-alcoholic fatty liver disease with comparable efficacy to fibroscan. Ultimately, we aim to demonstrate that these scoring systems can be used as an alternative to fibroscan in some patients. Methods Data was collected from 317 patient charts from the Vancouver General Hepatology Clinic. 93 patients were removed from the study due to insufficient data (missing Fibroscan score or lab work necessary for FIB-4/NFS). For the remaining 224 patients, FIB-4 and NFS were calculated and compared to fibrosis scores both independently and in combination. Results: Using a NFS score cut-off of -1.455 and a fibroscan score cut-off of ≥8.7kPa, the NFS had a sensitivity of 71.9%, a specificity of 75%, and a negative predictive value of 94.1%. For a fibroscan score cut-off of ≥8.0kPa, the NFS had a sensitivity of 66.7%, a specificity of 75.7%, and a negative predictive value of 91.5%. Using a fibroscan score cut-off of ≥8.7kPa, the FIB-4 score had a sensitivity of 53.1%, specificity of 84.9%, and a negative predictive value of 91.6%. For a cut-off of ≥8.0kPa, it had a sensitivity of 51.3%, and 85.9%, and a negative predictive value of 89.3%. Conclusions: The NFS and FIB-4 are non-invasive scoring systems that have high sensitivity and negative predictive value for fibrosis when compared to fibroscan scores. These findings suggest that the NFS and FIB-4 can provide adequate reassurance to rule-out fibrosis in select patients, and has promising use in the primary care setting where fibroscan access is often limited. Funding Agencies None

scholarly journals Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease

Gut ◽  
2010 ◽  
Vol 59 (9) ◽  
pp. 1265-1269 ◽  
Author(s):  
S. McPherson ◽  
S. F. Stewart ◽  
E. Henderson ◽  
A. D. Burt ◽  
C. P. Day
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Scoring Systems ◽  
Advanced Fibrosis ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease

The impact of modifiable risk factors on the long-term outcomes of non-alcoholic fatty liver disease

2019 ◽  
Vol 51 (2) ◽  
pp. 291-304 ◽  
Author(s):  
James M. Paik ◽  
Rati Deshpande ◽  
Pegah Golabi ◽  
Issah Younossi ◽  
Linda Henry ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Modifiable Risk Factors ◽  
Long Term Outcomes ◽  
Alcoholic Fatty Liver ◽  
The Impact ◽  
Alcoholic Fatty Liver Disease

Comparing the performance of Fibrosis-4 and Non-Alcoholic Fatty Liver Disease Fibrosis Score with transient elastography scores of people with non-alcoholic fatty liver disease

2021 ◽  
pp. e20210004
Author(s):  
Ben Cox ◽  
Roberto Trasolini ◽  
Ciaran Galts ◽  
Eric M Yoshida ◽  
Vladimir Marquez
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Fatty Liver Disease ◽  
Transient Elastography ◽  
Scoring Systems ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease

Background: With the rate of non-alcoholic fatty liver disease (NAFLD) on the rise, the necessity of identifying patients at risk of cirrhosis and its complications is becoming ever more important. Liver biopsy remains the gold standard for assessing fibrosis, although costs, risks, and availability prohibit its widespread use with at-risk patients. Transient elastography has proven to be a non-invasive and accurate way of assessing fibrosis, although the availability of this modality is often limited in primary care settings. The Fibrosis-4 (FIB-4) and Non-Alcoholic Fatty Liver Disease Fibrosis Score (NFS) are scoring systems that incorporate commonly measured lab parameters and BMI to predict fibrosis. Method: In this study, we compared FIB-4 and NFS scores with transient elastography scores to assess the accuracy of these inexpensive and readily available scoring systems in detecting fibrosis. Results: Using a NFS score cut-off of –1.455 and a FibroScan score cut-off of ≥8.7 kPa, the NFS score had a negative predictive value of 94.1%. Using a FibroScan score cut-off of ≥8.7 kPa, the FIB-4 score had a negative predictive value of 91.6%. Conclusion: The NFS and FIB-4 are non-invasive, inexpensive scoring systems that have high negative predictive value for fibrosis compared with transient elastography scores. These findings suggest that the NFS and FIB-4 can provide adequate reassurance to rule out fibrosis in patients with NAFLD and can be used with select patients to circumvent the need for transient elastography or liver biopsy.

scholarly journals PDB93 NAFLD SIMULATOR: A WEB-BASED SIMULATION TOOL TO PREDICT LONG-TERM OUTCOMES OF NON-ALCOHOLIC FATTY LIVER DISEASE

2020 ◽  
Vol 23 ◽  
pp. S125
Author(s):  
Ö.O. Dalgıç ◽  
S. Samur ◽  
K. Corey ◽  
E. Bethea ◽  
W. Chen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Simulation Tool ◽  
Long Term Outcomes ◽  
Web Based ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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