A cohort study of the universal neonatal urine screening for congenital cytomegalovirus infection

In our population-based screening study, the burden of congenital cytomegalovirus (cCMV) infection was low; the prevalence was only 0.2%, and neurodevelopmental, ophthalmological, and hearing outcomes in the CMV-positive infants did not differ from those of matched healthy controls at 18 months of age.

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Prospective Cohort Study of Congenital Cytomegalovirus Infection during Pregnancy with Fetal Growth Restriction: Serologic Analysis and Placental Pathology

The Journal of Pediatrics ◽

10.1016/j.jpeds.2018.10.003 ◽

2019 ◽

Vol 206 ◽

pp. 42-48.e2 ◽

Cited By ~ 5

Author(s):

Mitsuru Tsuge ◽

Akira I. Hida ◽

Toshio Minematsu ◽

Naotoshi Honda ◽

Yumi Oshiro ◽

...

Keyword(s):

Cohort Study ◽

Prospective Cohort Study ◽

Fetal Growth ◽

Fetal Growth Restriction ◽

Prospective Cohort ◽

Cytomegalovirus Infection ◽

Growth Restriction ◽

Placental Pathology ◽

Congenital Cytomegalovirus Infection ◽

Congenital Cytomegalovirus

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Clinical Factors Associated With Congenital Cytomegalovirus Infection: A Cohort Study of Pregnant Women and Newborns

Clinical Infectious Diseases ◽

10.1093/cid/ciz1156 ◽

2019 ◽

Vol 71 (11) ◽

pp. 2833-2839 ◽

Cited By ~ 2

Author(s):

Akiko Uchida ◽

Kenji Tanimura ◽

Mayumi Morizane ◽

Kazumichi Fujioka ◽

Ichiro Morioka ◽

...

Keyword(s):

Cohort Study ◽

Pregnant Women ◽

Cytomegalovirus Infection ◽

Second Trimester ◽

Premature Labor ◽

Clinical Factors ◽

Congenital Cytomegalovirus Infection ◽

Congenital Cytomegalovirus ◽

Factors Associated ◽

Threatened Miscarriage

Abstract Background The aim of this prospective cohort study was to determine clinical factors associated with the occurrence of congenital cytomegalovirus infection (cCMV) in pregnant women. Methods Between March 2009 and November 2017, newborns born at a primary maternity hospital received polymerase chain reaction (PCR) analyses for CMV DNA in their urine with informed consent of the mothers at a low risk. Clinical data, including age, gravidity, parity, body mass index, occupation, maternal fever/flulike symptoms, pregnancy complications, gestational weeks at delivery, birth weight, and automated auditory brainstem response, were collected. Logistic regression analyses were performed to determine clinical factors associated with cCMV. Results cCMV was diagnosed by positive PCR results of neonatal urine in 9 of 4125 pregnancies. Univariate and multivariable analyses revealed that the presence of fever/flulike symptoms (odds ratio [OR], 17.9; 95% confidence interval [CI], 3.7–86.7; P < .001) and threatened miscarriage/premature labor in the second trimester (OR, 6.0; 95% CI, 1.6–22.8; P < .01) were independent clinical factors associated with cCMV. Maternal fever/flulike symptoms or threatened miscarriage/premature labor in the second trimester had 100% sensitivity, 53.2% specificity, and a maximum Youden index of .85. Conclusions This cohort study for the first time demonstrated that these clinical factors of pregnant women and newborns were associated with the occurrence of cCMV. This is useful information for targeted screening to assess risks of cCMV in low-risk mothers, irrespective of primary or nonprimary CMV infection.

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2331. Seroprevalence of Cytomegalovirus in Pregnant Women and Birth Prevalence of Congenital Cytomegalovirus Infection in Henan Province, China

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.2009 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S801-S801

Author(s):

Yue Huang ◽

Tingdong Li ◽

Qiaoqiao Song ◽

Tengfei Man ◽

Han Wang ◽

...

Keyword(s):

Cohort Study ◽

Pregnant Women ◽

Cytomegalovirus Infection ◽

Maternal Age ◽

Maternal Education ◽

Henan Province ◽

Serological Testing ◽

Congenital Cytomegalovirus Infection ◽

Congenital Cytomegalovirus ◽

Birth Prevalence

Abstract Background Congenital cytomegalovirus infection (cCMVi) is the leading viral cause of birth defects and developmental disabilities in newborns. The epidemiology of cCMVi in settings with high cytomegalovirus (CMV) seroprevalence, such as China, is not well studied. This study sought to describe maternal CMV seroprevalence and cCMVi prevalence at birth in Henan Province, China. Methods A multicenter prospective cohort study was conducted in three counties of Henan Province in China from June 2015 through May 2018. Pregnant women were enrolled early in pregnancy and followed up through delivery. Serum specimens were collected at enrollment for CMV immunoglobulin G serological testing. Saliva and urine specimens were collected in newborns within 72 hours after birth and tested with real-time polymerase chain reaction for CMV DNA. cCMVi was defined as CMV DNA positive in the infants’ urine or saliva specimens. Results A total of 6327 pregnant women underwent CMV serological testing and 6062 were CMV seropositive (95.8%). The maternal age was 26.8 ± 4.3 (mean ± SD) years. There were 49 (0.7%) newborns identified with cCMVi among 6705 newborns screened. Lower maternal education level (middle school or lower), younger maternal age (<25 years) and twin-pregnancy were associated with higher cCMVi prevalence (P = 0.04, 0.016, and 0.001, respectively). Conclusion Despite a high maternal CMV seroprevalence in this large cohort study from China, the birth prevalence of cCMVi is similar to other studies in settings of high and medium CMV seroprevalence. In settings of high maternal CMV seroprevalence, additional research is needed to ascertain the relative contribution of non-primary CMV infections during pregnancy to congenital transmission. Disclosures All authors: No reported disclosures.

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