scholarly journals 2331. Seroprevalence of Cytomegalovirus in Pregnant Women and Birth Prevalence of Congenital Cytomegalovirus Infection in Henan Province, China

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S801-S801
Author(s):  
Yue Huang ◽  
Tingdong Li ◽  
Qiaoqiao Song ◽  
Tengfei Man ◽  
Han Wang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Cytomegalovirus Infection ◽  
Maternal Age ◽  
Maternal Education ◽  
Henan Province ◽  
Serological Testing ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Birth Prevalence

Abstract Background Congenital cytomegalovirus infection (cCMVi) is the leading viral cause of birth defects and developmental disabilities in newborns. The epidemiology of cCMVi in settings with high cytomegalovirus (CMV) seroprevalence, such as China, is not well studied. This study sought to describe maternal CMV seroprevalence and cCMVi prevalence at birth in Henan Province, China. Methods A multicenter prospective cohort study was conducted in three counties of Henan Province in China from June 2015 through May 2018. Pregnant women were enrolled early in pregnancy and followed up through delivery. Serum specimens were collected at enrollment for CMV immunoglobulin G serological testing. Saliva and urine specimens were collected in newborns within 72 hours after birth and tested with real-time polymerase chain reaction for CMV DNA. cCMVi was defined as CMV DNA positive in the infants’ urine or saliva specimens. Results A total of 6327 pregnant women underwent CMV serological testing and 6062 were CMV seropositive (95.8%). The maternal age was 26.8 ± 4.3 (mean ± SD) years. There were 49 (0.7%) newborns identified with cCMVi among 6705 newborns screened. Lower maternal education level (middle school or lower), younger maternal age (<25 years) and twin-pregnancy were associated with higher cCMVi prevalence (P = 0.04, 0.016, and 0.001, respectively). Conclusion Despite a high maternal CMV seroprevalence in this large cohort study from China, the birth prevalence of cCMVi is similar to other studies in settings of high and medium CMV seroprevalence. In settings of high maternal CMV seroprevalence, additional research is needed to ascertain the relative contribution of non-primary CMV infections during pregnancy to congenital transmission. Disclosures All authors: No reported disclosures.

scholarly journals Clinical Factors Associated With Congenital Cytomegalovirus Infection: A Cohort Study of Pregnant Women and Newborns

2019 ◽  
Vol 71 (11) ◽  
pp. 2833-2839 ◽  
Author(s):  
Akiko Uchida ◽  
Kenji Tanimura ◽  
Mayumi Morizane ◽  
Kazumichi Fujioka ◽  
Ichiro Morioka ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Cytomegalovirus Infection ◽  
Second Trimester ◽  
Premature Labor ◽  
Clinical Factors ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Factors Associated ◽  
Threatened Miscarriage

Abstract Background The aim of this prospective cohort study was to determine clinical factors associated with the occurrence of congenital cytomegalovirus infection (cCMV) in pregnant women. Methods Between March 2009 and November 2017, newborns born at a primary maternity hospital received polymerase chain reaction (PCR) analyses for CMV DNA in their urine with informed consent of the mothers at a low risk. Clinical data, including age, gravidity, parity, body mass index, occupation, maternal fever/flulike symptoms, pregnancy complications, gestational weeks at delivery, birth weight, and automated auditory brainstem response, were collected. Logistic regression analyses were performed to determine clinical factors associated with cCMV. Results cCMV was diagnosed by positive PCR results of neonatal urine in 9 of 4125 pregnancies. Univariate and multivariable analyses revealed that the presence of fever/flulike symptoms (odds ratio [OR], 17.9; 95% confidence interval [CI], 3.7–86.7; P &lt; .001) and threatened miscarriage/premature labor in the second trimester (OR, 6.0; 95% CI, 1.6–22.8; P &lt; .01) were independent clinical factors associated with cCMV. Maternal fever/flulike symptoms or threatened miscarriage/premature labor in the second trimester had 100% sensitivity, 53.2% specificity, and a maximum Youden index of .85. Conclusions This cohort study for the first time demonstrated that these clinical factors of pregnant women and newborns were associated with the occurrence of cCMV. This is useful information for targeted screening to assess risks of cCMV in low-risk mothers, irrespective of primary or nonprimary CMV infection.

scholarly journals 114. Birth Prevalence of Congenital Cytomegalovirus Infection and Language, Hearing, and Developmental Outcomes in a Cohort of HIV-Exposed, Uninfected Preschool Children

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S3-S3
Author(s):  
Murli Purswani ◽  
Tzy-Jyun Yao ◽  
Jonathan S Russell ◽  
Kathleen Malee ◽  
Stephen A Spector ◽  
...  
Keyword(s):  
United States ◽  
Cytomegalovirus Infection ◽  
Developmental Outcomes ◽  
The United States ◽  
Hiv Viral Load ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Birth Prevalence ◽  
Hiv Exposed ◽  
Exposed Uninfected

Abstract Background The prevalence of congenital cytomegalovirus infection (cCMV) at birth is 0.5%–1% in the United States. Most cCMV newborns are asymptomatic at birth with 10%–15% subsequently developing sequelae, such as hearing loss. Higher cCMV prevalence (2.5%–11.4%) is reported in infants born to HIV-infected women, associated with maternal immune suppression and lack of antiretroviral therapy (ART), with few studies addressing neurodevelopmental (ND) outcomes in their offspring. We report birth prevalence of cCMV in a cohort of HIV-exposed, uninfected infants (HEU) born to women on combination ART with well-controlled HIV and describe ND outcomes through age 5 years. Methods The Surveillance Monitoring for ART Toxicities (SMARTT) study is an ongoing NICHD-funded observational multi-centered cohort study (United States and Puerto Rico) of growth and development of HEU children that commenced in 2007. As of August 1, 2017, participants with stored blood pellets collected ≤3 weeks after birth and at least 1 ND assessment ≥1 year of age had pellets tested by DNA PCR to establish cCMV. Comparisons of ND outcomes (defined in figure) at ages 1, 2, and 5 by cCMV status were made using Wilcoxon and Fisher’s Exact tests. Results Of 895 children meeting study criteria (55% black; 32% white; 40% Latino), 8 had cCMV, yielding a birth prevalence of 0.89% (95% CI 0.39–1.75%). All were asymptomatic and similar to CMV-uninfected infants in gestational age and anthropometric measurements at birth. The last HIV viral load prior to delivery was undetectable in 88% of women. The last available CD4% was &lt;20% in 3/8 mothers of cCMV newborns compared with 112/873 in those without (38% vs. 13%, P &lt; 0.07). The mean duration of follow-up (± standard deviation) of children with cCMV was 7.2 years (1.6) and those without 5.9 (2.3) years (P &lt; 0.11). ND assessments for language development (CDI at 1, A&S at 2, TOLD-P:3 at 5), cognition (Bayleys-III at 1), intelligence (WPPSI-III at 5), and hearing (PTA at 5) did not differ by cCMV status (figure). Conclusion Birth prevalence of cCMV in HEU children born within the last decade approaches national US prevalence. Preschool HEU children with asymptomatic cCMV at birth did not show poorer language, hearing, and developmental outcomes compared with CMV-uninfected HEU children. Disclosures All authors: No reported disclosures.

scholarly journals Long-term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study

2017 ◽  
Vol 59 (12) ◽  
pp. 1261-1268 ◽  
Author(s):  
Marjolein J Korndewal ◽  
Anne Marie Oudesluys-Murphy ◽  
Aloys C M Kroes ◽  
Marianne A B van der Sande ◽  
Hester E de Melker ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus

Congenital cytomegalovirus infection in the Netherlands: Birth prevalence and risk factors

2011 ◽  
Vol 83 (10) ◽  
pp. 1777-1782 ◽  
Author(s):  
Jutte J.C. de Vries ◽  
Anna M.H. Korver ◽  
Paul H. Verkerk ◽  
Lisette Rusman ◽  
Eric C.J. Claas ◽  
...  
Keyword(s):  
Risk Factors ◽  
The Netherlands ◽  
Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Birth Prevalence

Disease burden of congenital cytomegalovirus infection at school entry age: study design, participation rate and birth prevalence

2015 ◽  
Vol 144 (7) ◽  
pp. 1520-1527 ◽  
Author(s):  
M. J. KORNDEWAL ◽  
A. C. T. M. VOSSEN ◽  
J. CREMER ◽  
R. S. VAN BINNENDIJK ◽  
A. C. M. KROES ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Participation Rate ◽  
Dried Blood Spots ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Birth Prevalence ◽  
Blood Spots ◽  
Health And Development ◽  
Polymerase Chain

SUMMARYCongenital cytomegalovirus infection (cCMV) may lead to symptoms at birth and long-term consequences. We present a nationwide, retrospective cohort study on the outcome of cCMV up to age 6 years. For this study we identified cCMV, using polymerase chain reaction, by analysing dried blood spots, which are taken shortly after birth for neonatal screening. The group of children with cCMV were compared to a group of children who were cCMV negative at birth. Data were collected about their health and development up to age 6 years. Parents of 73 693 children were invited to participate, and 32 486 (44·1%) gave informed consent for testing of their child's dried blood spot for CMV. Of the 31 484 dried blood spots tested, 156 (0·5%) were positive for cCMV. Of these, four (2·6%) children had been diagnosed with cCMV prior to this study. This unique retrospective nationwide study permits the estimation of long-term sequelae of cCMV up to the age of 6 years. The birth prevalence of cCMV in this study was 0·5%, which is in line with prior estimates. Most (97·4%) children with cCMV had not been diagnosed earlier, indicating under-diagnosis of cCMV.

scholarly journals The Burden of Congenital Cytomegalovirus Infection: A Prospective Cohort Study of 20 000 Infants in Finland

2018 ◽  
Vol 8 (3) ◽  
pp. 205-212 ◽  
Author(s):  
Laura Puhakka ◽  
Maija Lappalainen ◽  
Tuula Lönnqvist ◽  
Riina Niemensivu ◽  
Päivi Lindahl ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Cytomegalovirus Infection ◽  
Population Based ◽  
Healthy Controls ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Screening Study ◽  
Hearing Outcomes

In our population-based screening study, the burden of congenital cytomegalovirus (cCMV) infection was low; the prevalence was only 0.2%, and neurodevelopmental, ophthalmological, and hearing outcomes in the CMV-positive infants did not differ from those of matched healthy controls at 18 months of age.

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