232 Personal history of non-melanoma skin cancer diagnosis and death from melanoma in women

e14646 Background: Non-melanoma skin cancer (NMSC) is the most common form of human cancer. Aminolevulinic acid photodynamic therapy (ALA PDT) is a safe and effective treatment for NMSC precursors. It is unknown if ALA PDT treatment will affect incidence of NMSC in high risk patients (pts). Methods: A retrospective study was undertaken using a Veteran Affairs Boston Health Care System Medical Record Database. Study population included immunocompetent pts with history of NMSC, multiple actinic keratosis (AKs), and moderate to severe dermatoheliosis (DH). Study pts received a single application of 20 % ALA to the face or scalp following by exposure to blue light at 10 J/cm2. Differences in incidence of NMSC two years prior and two years after ALA PDT were tested using the Wilcoxon rank sum test. Data were analyzed by the median and interquartile range (IQR). Results: 43 Caucasian males (range 59- 87 yrs), 37 (87%) had history of NMSC on the face or scalp, 32 (78%) had basal cell carcinoma (BCC), 11 (22%) squamous cell carcinoma (SCC), 100% of patients had multiple (>4) AKs prior to treatment and 23 (75% ) had moderate to severe DH determined by Griffiths scale. Prior to ALA-PDT 74 NMSC's were documented: 40 (54%) BCC and 34 (46%) SCC. 46 NMSC's were documented following ALA-PDT: 22 (48%) BCC and 24 (52%) SCC. Prior to ALA-PDT, the frequency of BCC averaged 2 [IQR 1 to 3, max=4], and the frequency of SCC averaged 1 [IQR 1 to 1, max=3]. Following ALA-PDT, the occurrence of BCC averaged 1 [IQR 0 to 1, max=5], and that of SCC averaged 1 [IQR 0 to 2, max= 4]. The difference between BCC frequency before and after ALA-PDT treatment shown a significant reduction in BCC incidence (P = 0.0018). No such differences were observed between the frequency of SCC before and after ALA-PDT (P=0.6230) Conclusions: A single ALA-PDT treatment to the face or scalp in high risk patients significantly reduces the incidence of BCC, the incidence of SCC was not reduced. The potential role of ALA PDT as a NMSC chemopreventive modality warrants further investigation in larger samples with an alternative treatment protocols. No significant financial relationships to disclose.

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Prior history of non-melanoma skin cancer is associated with increased mortality in patients with chronic lymphocytic leukemia

Haematologica ◽

10.3324/haematol.2008.004721 ◽

2009 ◽

Vol 94 (10) ◽

pp. 1460-1464 ◽

Cited By ~ 13

Author(s):

J. R. Toro ◽

P. W. Blake ◽

M. Bjorkholm ◽

S. Y. Kristinsson ◽

Z. Wang ◽

...

Keyword(s):

Skin Cancer ◽

Chronic Lymphocytic Leukemia ◽

Lymphocytic Leukemia ◽

Prior History ◽

Non Melanoma Skin Cancer ◽

History Of ◽

Melanoma Skin

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Sun-Related Behaviors of Outdoor Working Men with a History of Non-Melanoma Skin Cancer

Journal of Occupational and Environmental Medicine ◽

10.1097/00043764-200209000-00007 ◽

2002 ◽

Vol 44 (9) ◽

pp. 847-854 ◽

Cited By ~ 29

Author(s):

Torres Woolley ◽

Petra G. Buettner ◽

John Lowe

Keyword(s):

Skin Cancer ◽

Non Melanoma Skin Cancer ◽

History Of ◽

Melanoma Skin

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Epidemiology of Non-Melanoma Skin Cancer Patients Attending at Hiwa Hospital in Sulaimani City, Iraq

Kurdistan Journal of Applied Research ◽

10.24017/science.2018.2.7 ◽

2018 ◽

pp. 44-48

Author(s):

Bushra Mohammed Ali ◽

Hiwa Abas Ahmed

Keyword(s):

Squamous Cell Carcinoma ◽

Family History ◽

Skin Cancer ◽

Cell Carcinoma ◽

P Value ◽

Level Of Education ◽

Non Melanoma Skin Cancer ◽

History Of ◽

Sun Light ◽

Melanoma Skin

Objectives are to identify the frequency of non-melanoma skin cancer cases were registered at Hiwa hospital and to find out the association between cases and controls with their sociodemographic status and risk factors. A case control approach was used, by retrospective chart review of all non-melanoma skin cancer cases presented between 1st of January 2015 till 31st of December 2016 at Sulaimani Hiwa hospital from which 70 cases conducted and 70 controls from Baxshen hospital. Data entered to Microsoft excel, analysed by SPSS V 21. Chi-square test was employed to assess the association between different variables, P value of 0.05 or less considered as statistical significant This study included 70 cases and 70 controls were age and gender matched, most of the cases were in between age 56-70 years old, illiterate 39(55.7%), jobless 26(37.1%), from urban area 45 (64.3%) , married 65 (92.9%). had sufficient income and barely sufficient. About (64%) of cases had squamous cell carcinoma and (36%) had basal cell carcinoma. Most of the cases had family history of skin cancer (11.4%), and 44 (62.9%) of cases had a history of more than 4 hours exposure to sun in a day and 36 (51.4%) of cases were with normal BMI. Most of the cases 32 (45.7%) with type (O) blood group, not smoking cigarette 51 (72.9%) and not drinking alcohol 69 (98.6%). This study showed a statistical significant association between non-melanoma skin cancer with level of education (P value =0.002), family history (P value = 0.02), time of exposure to sun light (P value of < 0.001) and BMI (p value = 0.001). Skin cancer and cancer percentage were in increase pattern especially non-melanoma skin cancer, most of non-melanoma skin cancer cases were squamous cell carcinoma, with a significant association with level of education, income status, time of exposure to sun light, family history and BMI

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Two shades of malignancy in a psoriatic patient

Our Dermatology Online ◽

10.7241/ourd.20214.20 ◽

2021 ◽

Vol 12 (4) ◽

pp. 436-438

Author(s):

Meryam Chaabani ◽

Kahena Jaber ◽

Faten Rebhi

Keyword(s):

Skin Cancer ◽

Chronic Inflammation ◽

Pustular Psoriasis ◽

Psoriatic Patient ◽

Non Melanoma Skin Cancer ◽

Increased Risk ◽

History Of ◽

Melanoma Skin

Psoriasis is a chronic inflammation of the skin, affecting approx. 120 million people worldwide. The risk of developing skin cancer in psoriatic patients has been stressed, although with a significant amount of conflicting data in the literature. The most consistent findings suggest that psoriatic patients are at an increased risk of non-melanoma skin cancer. An increased risk of melanoma has not been well established. Herein, we report the case of a patient with a history of pustular psoriasis present since the age of ten, who developed an SCC and a melanoma, and discuss the etiopathology of this association.

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