scholarly journals Role of antinuclear antibodies in COVID-19 patients

2022 ◽  
pp. 113215
Author(s):  
Linda Beenet
Keyword(s):  
Antinuclear Antibodies

scholarly journals P273 The role of multimodality imaging in the evaluation of arteritis

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
T M Matajira Chia ◽  
M Castineira Busto ◽  
M Cespon Fernandez ◽  
B Gimena Reyes ◽  
F Calvo Iglesias ◽  
...  
Keyword(s):  
Antinuclear Antibodies ◽  
Aortic Wall ◽  
Multimodality Imaging ◽  
Lateral Wall ◽  
Ascending Aorta ◽  
Iliac Arteries ◽  
Positron Emission ◽  
Nuclear Antigens ◽  
Pet Ct

Abstract A 61-year-old man was admitted to the hospital with an atypical pain lumbar with oligoanuria. Other comorbidities were: arterial hypertension, diabetes mellitus and smoking .On examination the patient was comfortable at rest, with a heart rate of 89 b.p.m. and a blood pressure of 147/2 mmHg. Normal S1 and S2 heart sounds were present. There were no signs of heart failure present. Patients complained of pain in hypogastrium on palpation. Creatinine 2.33 mg / dL. PCR 72. The immunological studies were normal (including IgG and IgA serological levels, antinuclear antibodies, extractable nuclear antigens, anti-neutrophil cytoplasmic antibodies. An Body CT was performed, it shows mass that includes the ureters as well as the iliac arteries and parietal thickening in aorta wall. The positron emission tomography–computed tomography (PET CT) scans was performed that evidences pathological hypermetabolism that surrounds both primitive iliac arteries with maximum SUV 12 g / ml. Pathological hypermetabolism in ascending aorta until reaching arch with maximum SUV of 9.1 mg / ml compatible with periaortitis in the ascending aorta. A study was completed with retroperitoneal mass biopsy that showed areas of retroperitoneal fibrosis with predominantly lymphoplasmacytic areas. IgG4 / IgG> 40% , Obliterative involvement of small venules suggestive of IgG4 disease. A transthoracic echocardiogram was performed which showed normal biventricular function, absence of significant valvular disease and thickening of the aortic wall compatible with periaortitis. The patient started glucocorticoid therapy with favorable response. A PET CT control was performed that showed disappearing retroperitoneal masses around iliac vessels and disappearance of activity in lateral wall of aorta and decrease activity about ascendent aorta. DIAGNOSIS : IgG4 -related aortitis Abstract P273 Figure.

Role of Antinuclear Antibodies in Primary Biliary Cholangitis

2020 ◽  
Vol 115 (10) ◽  
pp. 1604-1606
Author(s):  
Cynthia Levy ◽  
Christopher L. Bowlus
Keyword(s):  
Antinuclear Antibodies ◽  
Primary Biliary Cholangitis

scholarly journals Prevalence of Antinuclear Antibodies in Schoolchildren During Puberty and Possible Relationship with Musculoskeletal Pain: A Longitudinal Study

2014 ◽  
Vol 41 (7) ◽  
pp. 1405-1408 ◽  
Author(s):  
Francesca Sperotto ◽  
Giorgio Cuffaro ◽  
Sara Brachi ◽  
Mara Seguso ◽  
Francesco Zulian
Keyword(s):  
Public Schools ◽  
Longitudinal Study ◽  
Musculoskeletal Pain ◽  
Clinical Examination ◽  
Laboratory Tests ◽  
Antinuclear Antibodies ◽  
Hormonal Changes ◽  
Pubertal Stage ◽  
Autoantibody Profile

Objective.The role of antinuclear antibodies (ANA) in children has still to be elucidated. The aim of our study was to evaluate the prevalence and persistence of ANA in schoolchildren during the puberty switch, and the possible relationship with chronic noninflammatory musculoskeletal pain (MSP).Methods.Children aged 8–13 years and attending 4 public schools underwent a clinical examination, focusing on pubertal stage and presence of chronic noninflammatory MSP. Laboratory tests to determine the autoantibody-profile were also performed. Subjects with ANA positivity (titer ≥ 1:80) and/or chronic noninflammatory MSP were re-evaluated 3 years later.Results.Two hundred sixty-one subjects enrolled in the study and 12.3% were ANA-positive, equally distributed in terms of sex and pubertal status. Three years later, in the group of patients studied for chronic noninflammatory MSP (n = 67), ANA positivity significantly increased from 13.4% to 44.8%. In the ANA-positive cohort at baseline (n = 28), 92.9% of subjects were confirmed as being ANA-positive with a significantly increased titer. No association between ANA positivity and chronic noninflammatory MSP was found.Conclusion.ANA prevalence and titers increase during puberty, especially in females, but have no relationship with chronic noninflammatory MSP. This finding may be related to the complex hormonal changes during the puberty switch period and opens new insights into autoimmunity.

scholarly journals Autoantibodies to speckled protein family in primary biliary cholangitis

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Alessandro Granito ◽  
Luigi Muratori ◽  
Francesco Tovoli ◽  
Paolo Muratori
Keyword(s):  
Antinuclear Antibodies ◽  
Nuclear Body ◽  
Primary Biliary Cholangitis ◽  
Immune Disorders ◽  
Therapeutic Approaches ◽  
Body Protein ◽  
Promyelocytic Leukemia Protein ◽  
Autoantibody Profile ◽  
Protein Alterations

AbstractThe autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered “PBC-specific” is the so-called “multiple nuclear dots” (MND) targeting nuclear body proteins such as Sp100, Sp140, Sp140L proteins, promyelocytic leukemia protein (PML) and small ubiquitin-related modifier proteins (SUMO). It has been hypothesized a role of nuclear body protein alterations in immune disorders such as PBC, thus suggesting novel and more refined therapeutic approaches.

Role of Antinuclear Antibodies in Experimental and Clinical Liver Transplantation

2006 ◽  
Vol 38 (10) ◽  
pp. 3605-3606 ◽  
Author(s):  
T. Nakano ◽  
C.-Y. Lai ◽  
S. Goto ◽  
L.-W. Hsu ◽  
Y.-C. Lin ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Antinuclear Antibodies

scholarly journals Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease

2020 ◽  
Author(s):  
Irina A Pashnina ◽  
Irina M Krivolapova ◽  
Tamara V Fedotkina ◽  
Varvara A Ryabkova ◽  
Margarita V Chereshneva ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Young People ◽  
Autoimmune Diseases ◽  
Antinuclear Antibodies ◽  
Normal Range ◽  
Cell Functions ◽  
Low Concentrations ◽  
Antinuclear Autoantibodies ◽  
Underlying Causes

Incidence of autoimmune diseases increases. Antinuclear antibodies (ANA) testing is a critical tool for their diagnosis. However, ANA prevalence in health increased over last decades, especially among young people. ANA in health occur in low concentrations, with prevalence up to 50% in some populations, which demands a cutoff revision. The review deals with origin and probable physiological or compensatory function of ANA in health, according to the concept of immunological clearance, theory of autoimmune regulation of cell functions and the concept of functional autoantibodies. Considering ANA titers ≤1:320 as a serological marker of autoimmune diseases seems inappropriate. The role of anti-DFS70/LEDGFp75 autoantibodies is highlighted as possible anti-risk biomarker for autoimmune rheumatic disorders. ANA prevalence in health is different in various regions due to several underlying causes discussed in the review, all influencing in additive combinations according to the concept of the mosaic of autoimmunity. Not only titer, but the HEp-2 IFA staining patterns, like AC-2, is also important. Accepting autoantibodies as a kind of bioregulators, not only upper, but also lower borders of their normal range should be determined. Not only their excess, but also lack of them or “autoimmunodeficiency” could be a reason of disorders.

scholarly journals Neutrophil Extracellular Traps Contribute to COVID-19 Hyperinflammation and Humoral Autoimmunity

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2545
Author(s):  
Jiram Torres-Ruiz ◽  
Abdiel Absalón-Aguilar ◽  
Miroslava Nuñez-Aguirre ◽  
Alfredo Pérez-Fragoso ◽  
Daniel Alberto Carrillo-Vázquez ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Antinuclear Antibodies ◽  
Neutrophil Extracellular Traps ◽  
Low Density ◽  
Dna Complexes ◽  
Extracellular Traps ◽  
Enhanced Production ◽  
Cytokine Levels ◽  
Humoral Autoimmunity

The coronavirus disease 2019 (COVID-19) is related to enhanced production of NETs, and autoimmune/autoinflammatory phenomena. We evaluated the proportion of low-density granulocytes (LDG) by flow cytometry, and their capacity to produce NETs was compared with that of conventional neutrophils. NETs and their protein cargo were quantified by confocal microscopy and ELISA. Antinuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA) and the degradation capacity of NETs were addressed in serum. MILLIPLEX assay was used to assess the cytokine levels in macrophages’ supernatant and serum. We found a higher proportion of LDG in severe and critical COVID-19 which correlated with severity and inflammatory markers. Severe/critical COVID-19 patients had higher plasmatic NE, LL-37 and HMGB1-DNA complexes, whilst ISG-15-DNA complexes were lower in severe patients. Sera from severe/critical COVID-19 patients had lower degradation capacity of NETs, which was reverted after adding hrDNase. Anti-NET antibodies were found in COVID-19, which correlated with ANA and ANCA positivity. NET stimuli enhanced the secretion of cytokines in macrophages. This study unveils the role of COVID-19 NETs as inducers of pro-inflammatory and autoimmune responses. The deficient degradation capacity of NETs may contribute to the accumulation of these structures and anti-NET antibodies are related to the presence of autoantibodies.

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