Susceptibility of epidemic viruses to neuraminidase inhibitors and treatment-emergent resistance in the Japanese 2019-20 influenza season

2021 ◽  
Author(s):  
Naoki TANI ◽  
Naoki KAWAI ◽  
Yong CHONG ◽  
Takuma BANDO ◽  
Norio IWAKI ◽  
...  
Keyword(s):  
Influenza Season ◽  
Neuraminidase Inhibitors

scholarly journals Start of the influenza season 2008-9 in Europe - increasing influenza activity moving from West to East dominated by A(H3N2)

2009 ◽  
Vol 14 (3) ◽  
Author(s):  
N Goddard ◽  
P Zucs ◽  
B Ciancio ◽  
F Plata ◽  
O Hungnes ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Influenza Vaccine ◽  
Northern Hemisphere ◽  
Virus Type ◽  
Influenza Season ◽  
Type A ◽  
Neuraminidase Inhibitors ◽  
Influenza Activity

The influenza season 2008-9 started in week 49 of 2008 and is so far characterised by influenza virus type A subtype H3N2. Isolates of this subtype that were tested proved susceptible to neuraminidase inhibitors, but resistant to M2 inhibitors. The circulating A(H3N2) viruses are antigenically similar to the component in the current northern hemisphere influenza vaccine.

scholarly journals Characterization of influenza A(H1N1)pdm09 viruses in Germany in season 2019-2020 – co-circulation of an antigenic drift variant

2021 ◽  
Author(s):  
Marianne Wedde ◽  
Djin-Ye Oh ◽  
Silke Buda ◽  
Andrea Thürmer ◽  
Sandra Kaiser ◽  
...  
Keyword(s):  
Influenza A ◽  
Influenza Season ◽  
Vaccine Virus ◽  
Influenza Viruses ◽  
Antigenic Drift ◽  
Neuraminidase Inhibitors ◽  
Pdm09 Virus ◽  
Time Period ◽  
Influenza A H1n1

Background Influenza A(H1N1)pdm09 virus entered the human population in 2009 and evolved within this population for more than ten years. Despite genetic evolution no remarkable changes in the antigenic reactive pattern of these viruses were observed so far. Methods Primary respiratory samples of the German influenza virological sentinel were investigated by qPCR. Influenza virus-positive samples were characterized genetically and antigenetically. Results In December 2019, a antigenic drift variant characterized by an N156K substitution in the hemagglutinin of influenza A(H1N1)pdm09 virus emerged in Germany, which exhibited a reactivity to ferret antiserum that was an average 6 log2 lower than the vaccine virus A/Brisbane/02/2018 and the other A(H1N1)pdm09 viruses circulating in the influenza season 2019-2020. These viruses accounted for 20% of all A(H1N1)pdm09 viruses characterized in the German influenza sentinel. Patients infected with these viruses had a shorter median time period of medical consultation after onset of symptoms and were more frequently treated with neuraminidase inhibitors in comparison to patients infected with other A(H1N1)pdm09 viruses. Conclusions This parallel circulation of two antigenic variants of A(H1N1)pdm09 viruses which differ remarkably in their antigenic reactive pattern contributes to a greater variability in circulating influenza viruses and challenges vaccination.

A(H1N1)v cases of the 2009/2010 and 2010/2011 influenza seasons in the Medical and Health Sciences Centre of Debrecen University

2012 ◽  
Vol 153 (17) ◽  
pp. 649-654
Author(s):  
Piroska Orosi ◽  
Judit Szidor ◽  
Tünde Tóthné Tóth ◽  
József Kónya
Keyword(s):  
High Risk ◽  
Influenza Season ◽  
National Level ◽  
Organ Transplant ◽  
High Risk Patient ◽  
Risk Groups ◽  
Health Sciences ◽  
World Health ◽  
Transplant Patients ◽  
Health Organization

The swine-origin new influenza variant A(H1N1) emerged in 2009 and changed the epidemiology of the 2009/2010 influenza season globally and at national level. Aims: The aim of the authors was to analyse the cases of two influenza seasons. Methods: The Medical and Health Sciences Centre of Debrecen University has 1690 beds with 85 000 patients admitted per year. The diagnosis of influenza was conducted using real-time polymerase chain reaction in the microbiological laboratories of the University and the National Epidemiological Centre, according to the recommendation of the World Health Organization. Results: The incidence of influenza was not higher than that observed in the previous season, but two high-risk patient groups were identified: pregnant women and patients with immunodeficiency (oncohematological and organ transplant patients). The influenza vaccine, which is free for high-risk groups and health care workers in Hungary, appeared to be effective for prevention, because in the 2010/2011 influenza season none of the 58 patients who were administered the vaccination developed influenza. Conclusion: It is an important task to protect oncohematological and organ transplant patients. Orv. Hetil., 2012, 153, 649–654.

Improving vaccine uptake: a new uptake reporting tool

2018 ◽  
Vol 68 (suppl 1) ◽  
pp. bjgp18X697205
Author(s):  
Elise Tessier ◽  
Richard Pebody ◽  
Nicki Boddington ◽  
Michael Edelstein ◽  
Joanne White ◽  
...  
Keyword(s):  
Reporting System ◽  
Influenza Season ◽  
Vaccine Uptake ◽  
Web Based ◽  
Current Season ◽  
Previous Season ◽  
Uptake Rates ◽  
Reporting Tool ◽  
Uptake Data ◽  
Near Future

BackgroundVaccine uptake data is automatically extracted from all GP practices in England via the web-based reporting system, ImmForm, on behalf of Public Health England. In 2016/17, an Uptake Summary Tool was introduced on ImmForm for practice managers, clinical commissioning groups (CCGs) and screening and immunisation teams (SCRIMMS) to help facilitate local and regional management of the influenza programme. The tool allows practices to view and evaluate influenza uptake rates by target cohorts, comparing them against the previous season and CCG average/overall national uptake each week.AimTo assess how many practices use the Uptake Summary Tool and whether there is a difference in vaccine uptake among practices that use the tool compared with those that don’t during the 2016/17 and 2017/18 influenza seasons.MethodPractice level use of the Uptake Summary Tool was examined for the 2016/17 influenza season and vaccine uptake compared between practices that used the tool and those that did not.ResultsAn average of 1272 practices used the tool each week during the 2016/17. Vaccine uptake was on average 2.9% greater for targeted cohorts in practices that used the tool than practices that did not during the 2016/17 season.ConclusionWhen used on a regular basis the Uptake Summary Tool can help GP practices, CCGs and SCRIMMS monitor vaccine and may be associated with increased vaccine uptake. Uptake for the 2017/18 season will be monitored and assessed throughout the current season. We aim to expand the tool to other vaccine collections in the near future.

Sign in / Sign up

Export Citation Format

Share Document