scholarly journals Complete Ion-Coordination Structure in the Rotor Ring of Na+-Dependent F-ATP Synthases

2009 ◽  
Vol 391 (2) ◽  
pp. 498-507 ◽  
Author(s):  
Thomas Meier ◽  
Alexander Krah ◽  
Peter J. Bond ◽  
Denys Pogoryelov ◽  
Kay Diederichs ◽  
...  
2011 ◽  
Vol 413 (3) ◽  
pp. 657-666 ◽  
Author(s):  
Ragunathan Priya ◽  
Anil Kumar ◽  
Malathy Sony Subramanian Manimekalai ◽  
Gerhard Grüber
Keyword(s):  

2002 ◽  
Vol 269 (22) ◽  
pp. 5581-5589 ◽  
Author(s):  
Christoph von Ballmoos ◽  
Thomas Meier ◽  
Peter Dimroth
Keyword(s):  

2010 ◽  
Vol 395 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Alexander Krah ◽  
Denys Pogoryelov ◽  
Thomas Meier ◽  
José D. Faraldo-Gómez

2018 ◽  
Author(s):  
Hui Guo ◽  
Toshiharu Suzuki ◽  
John L. Rubinstein

AbstractATP synthases produce ATP from ADP and inorganic phosphate with energy from a transmembrane proton motive force. Bacterial ATP synthases have been studied extensively because they are the simplest form of the enzyme and because of the relative ease of genetic manipulation of these complexes. We expressed theBacillusPS3 ATP synthase inEschericia coli, purified it, and imaged it by cryo-EM, allowing us to build atomic models of the complex in three rotational states. The position of subunitεshows how it is able to inhibit ATP hydrolysis while allowing ATP synthesis. The architecture of the membrane region shows how the simple bacterial ATP synthase is able to perform the same core functions as the equivalent, but more complicated, mitochondrial complex. The structures reveal the path of transmembrane proton translocation and provide a model for understanding decades of biochemical analysis interrogating the roles of specific residues in the enzyme.


2021 ◽  
Author(s):  
Tobias Neidel ◽  
Jakob Heins ◽  
Katharina Herrmann ◽  
André Martignoni ◽  
Thomas Zinsmeister ◽  
...  

Abstract BackgroundThe second wave of Corona-Pandemic posed the German Healthcare system to a major challenge. Due to the fast and wide spreading of SARS-CoV-2 in November 2020, the number of COVID-19-patients needing intensive care treatment was rapidly growing. Transferring patients between hospitals was necessary to prevent an overflow of treatment capacities within the ambulance district of Augsburg. This project aimed to create a coordination structure that ensures an efficient guiding of all hospitals within the ambulance district Augsburg.Material and methodsAn executive order of the Bavarian ministries of health and internal affairs 1 lead to the appointment of a Medical Director of Hospital Coordination (MDHC) within each ambulance district. Each hospital had to nominate a pandemic officer (PO). Based on the executive order and the “disaster management manual 100” we established a hospital coordination structure for the ambulance district Augsburg.ResultsBetween October 18th, 2020, and February 14th, 2021, the staff of the MDHC coordinated 407 transfers of patients. 223 patients were treated on a general ward, 184 on intensive care units. The transfers prevented several impending triage situations. Using the coordination structure, the urgent reduction of a COVID-19 intensive care unit of a level 1 hospital from 7 to 2 beds was managed within 4 hours after an alarm. ConclusionsBased on the “disaster management manual 100”2 we were able to establish a hospital coordination structure that can withstand high pressure and ensured that impending triage situations were prevented. Urgent shortages of treatment capacities were balanced through the transfer of patients. The major problem was the lack of intensive care personnel.


2003 ◽  
Vol 195 (1) ◽  
pp. 275-280
Author(s):  
Eishun Tsuchida ◽  
Akito Nakagawa ◽  
Teruyuki Komatsu

2008 ◽  
Vol 1777 ◽  
pp. S20
Author(s):  
Natalya V. Dudkina ◽  
Gert Ooostergetel ◽  
Wilko Keegstra ◽  
Jesco Heinemeyer ◽  
Hans-Peter Braun ◽  
...  

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