Network-Based Drug Discovery: Coupling Network Pharmacology with Phenotypic Screening for Neuronal Excitability

2018 ◽  
Vol 430 (18) ◽  
pp. 3005-3015 ◽  
Author(s):  
Ben Sidders ◽  
Anna Karlsson ◽  
Linda Kitching ◽  
Rubben Torella ◽  
Paul Karila ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Neuronal Excitability ◽  
Network Pharmacology ◽  
Phenotypic Screening

COMPUTATIONAL APPROACHES FOR DRUG DISCOVERY FROM MEDICINAL PLANTS IN THE ERA OF DATA DRIVEN RESEARCH

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (08) ◽  
pp. 7-23
Author(s):  
Pratibha Pansari ◽  
Keyword(s):  
Drug Discovery ◽  
Medicinal Plants ◽  
In Silico ◽  
Drug Target ◽  
Target Gene ◽  
Scientific Work ◽  
Data Driven ◽  
Network Pharmacology ◽  
Gene Pathway ◽  
Topological Network

The significant scientific work on the development of bio-active compound databases, computational technologies, and the integration of Information Technology with Biotechnology has brought a revolution in the domain of drug discovery. These tools facilitate the medicinal plant-based in silico drug discovery, which has become the frontier of pharmacological science. In this review article, we elucidate the methodology of in silico drug discovery for the medicinal plants and present an outlook on recent tools and technologies. Further, we explore the multi-component, multi-target, and multi-pathway mechanism of the bio-active compounds with the help of Network Pharmacology, which enables us to create a topological network between drug, target, gene, pathway, and disease.

scholarly journals Next-Generation Phenotypic Screening in Early Drug Discovery for Infectious Diseases

2019 ◽  
Vol 35 (7) ◽  
pp. 559-570 ◽  
Author(s):  
Nathalie Aulner ◽  
Anne Danckaert ◽  
JongEun Ihm ◽  
David Shum ◽  
Spencer L. Shorte
Keyword(s):  
Drug Discovery ◽  
Infectious Diseases ◽  
Phenotypic Screening ◽  
Next Generation ◽  
Early Drug

Network Pharmacology to Aid the Drug Discovery Process

2012 ◽  
pp. 161-172 ◽  
Author(s):  
Ruth Dannenfelser ◽  
Huilei Xu ◽  
Catherine Raimond ◽  
Avi Ma’ayan
Keyword(s):  
Drug Discovery ◽  
Network Pharmacology ◽  
Discovery Process ◽  
Drug Discovery Process

Rectifying cancer drug discovery through network pharmacology

2014 ◽  
Vol 6 (5) ◽  
pp. 529-539 ◽  
Author(s):  
Asfar S Azmi ◽  
Ramzi M Mohammad
Keyword(s):  
Drug Discovery ◽  
Cancer Drug ◽  
Network Pharmacology ◽  
Cancer Drug Discovery

scholarly journals Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Jian Li ◽  
Cheng Lu ◽  
Miao Jiang ◽  
Xuyan Niu ◽  
Hongtao Guo ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Pattern Classification ◽  
Synergistic Effects ◽  
Molecular Networks ◽  
Network Pharmacology ◽  
Herbal Formula ◽  
Drug Candidates ◽  
New Drug

Current strategies for drug discovery have reached a bottleneck where the paradigm is generally “one gene, one drug, one disease.” However, using holistic and systemic views, network pharmacology may be the next paradigm in drug discovery. Based on network pharmacology, a combinational drug with two or more compounds could offer beneficial synergistic effects for complex diseases. Interestingly, traditional chinese medicine (TCM) has been practicing holistic views for over 3,000 years, and its distinguished feature is using herbal formulas to treat diseases based on the unique pattern classification. Though TCM herbal formulas are acknowledged as a great source for drug discovery, no drug discovery strategies compatible with the multidimensional complexities of TCM herbal formulas have been developed. In this paper, we highlighted some novel paradigms in TCM-based network pharmacology and new drug discovery. A multiple compound drug can be discovered by merging herbal formula-based pharmacological networks with TCM pattern-based disease molecular networks. Herbal formulas would be a source for multiple compound drug candidates, and the TCM pattern in the disease would be an indication for a new drug.

scholarly journals Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screening

2019 ◽  
Vol 72 (10) ◽  
pp. 719-728 ◽  
Author(s):  
Edyta M. Grzelak ◽  
Mary P. Choules ◽  
Wei Gao ◽  
Geping Cai ◽  
Baojie Wan ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Drug Discovery ◽  
Phenotypic Screening
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