The Effectiveness of Mammography as a Screening Method to Detect Breast Cancer in High Breast Density Populations

2019 ◽  
Vol 50 (2) ◽  
pp. S3
Author(s):  
Hailey M. Richards ◽  
Chelsea Wandziak ◽  
Ubi Wichoski
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Screening Method ◽  
Detect Breast Cancer

scholarly journals Breast density does not impact the ability of Videssa® Breast to detect breast cancer in women under age 50

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0186198 ◽  
Author(s):  
David E. Reese ◽  
Meredith C. Henderson ◽  
Michael Silver ◽  
Rao Mulpuri ◽  
Elias Letsios ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Detect Breast Cancer

scholarly journals A cross-sectional study exploring the justification of opportunistic breast cancer screening in Thailand

2021 ◽  
Author(s):  
Bhoowit Lerttiendamrong ◽  
Lertpong Satapongpeera ◽  
Mawin Vongsaisuwon
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Breast Density ◽  
Screening Method ◽  
Cross Sectional Study ◽  
Screening Mammography ◽  
Breast Ultrasonography ◽  
Cross Sectional ◽  
Dense Breasts

Objective: Breast cancer is currently the most common malignant disease in Thailand. The present study aims to evaluate the most beneficial method of breast cancer screening in different breast densities by analyzing the benefits of screening mammography with additional breast ultrasonography classified by breast density. Method: 49 middle-aged and elderly Bangkokian women who had undergone both mammography and ultrasonography were picked at random for analysis. BI-RADS scores were assigned based on mammography results alone and based on combined mammography and ultrasonography results. Concordance/discordance rates between the 2 radiographic techniques were compared in women stratified based on their breast densities. Results: All of our participants were given a score between BIRADS 1 and 3, while over 40% of participants are in the BIRADS 2 category. 60% of subjects with extremely dense breasts benefit from screening mammography with additional breast ultrasonography, while only 50% of samples with heterogeneous density and 34.21% samples with heterogeneous fibroglandular breasts benefit from the extra intervention. Conclusion: Our study concludes that women with higher breast density are more likely to benefit from screening using ultrasonography in addition to mammography as opposed to mammography screening alone. We recommend both mammography and ultrasonography for initial breast cancer screening. For follow-up visits, we suggest the screening method in accordance with breast density, using ultrasonography alone for women with high breast densities and mammography for women with heterogeneously dense breasts.

scholarly journals Relationship of mammographic densities to breast cancer risk

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Engy A. Ali ◽  
Mariam Raafat
Keyword(s):  
Breast Cancer ◽  
Breast Density ◽  
Statistical Significance ◽  
Significant Risk ◽  
Close Relation ◽  
Mammographic Screening ◽  
Mammographic Breast Density ◽  
Study Results ◽  
Relationship Of ◽  
Mammographic Densities

Abstract Background Our goal was to find out the relation between mammographic densities and cancer of the breast according to the recent ACR classification. From the medical records of Kasereliny Hospital, 49,409 women were subjected to digital mammography for screening, of which 1500 breast cancer cases were collected. The mammographic categories of breast density were ACR-A, B, C, and D, which were detected by two senior radiologists. All radiological classifications were made using both standard mammographic views bilaterally. Two-sided tests of statistical significance were represented by all the P values. Results From 2014 to 2019, 49,409 women came for digital mammographic screening, their age ranges between 40 and 65, and all of them are included in the study. One thousand cases of breast cancer cases were radiologically and pathologically diagnosed. Different densities were arranged in descending pattern depending on the frequency of positive cases: D (13.7%), C (3.3%), B (2.7%), A (2.2%). There is positive significant risk ratio among every higher mammographic density in comparison to the lower density. Conclusion Our study results show that the risk of breast cancer is in close relation to the mammographic breast density.

scholarly journals Breast Cancer Detection from a Urine Sample by Dog Sniffing: A Preliminary Study for the Development of a New Screening Device and a Literature Review

Biology ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 517
Author(s):  
Shoko Kure ◽  
Shinya Iida ◽  
Marina Yamada ◽  
Hiroyuki Takei ◽  
Naoyuki Yamashita ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Cancer Patients ◽  
Urine Sample ◽  
Urine Samples ◽  
Breast Cancer Patients ◽  
Double Blind ◽  
Blind Test ◽  
Preliminary Study ◽  
Detect Breast Cancer

Background: Breast cancer is a leading cause of cancer death worldwide. Several studies have demonstrated that dogs can sniff and detect cancer in the breath or urine sample of a patient. This study aims to assess whether the urine sample can be used for breast cancer screening by its fingerprints of volatile organic compounds using a single trained sniffer dog. This is a preliminary study for developing the “electronic nose” for cancer screening. Methods: A nine-year-old female Labrador Retriever was trained to identify cancer from urine samples of breast cancer patients. Urine samples from patients histologically diagnosed with primary breast cancer, those with non-breast malignant diseases, and healthy volunteers were obtained, and a double-blind test was performed. Total of 40 patients with breast cancer, 142 patients with non-breast malignant diseases, and 18 healthy volunteers were enrolled, and their urine samples were collected. Results: In 40 times out of 40 runs of a double-blind test, the trained dog could correctly identify urine samples of breast cancer patients. Sensitivity and specificity of this breast cancer detection method using dog sniffing were both 100%. Conclusions: The trained dog in this study could accurately detect breast cancer from urine samples of breast cancer patients. These results indicate the feasibility of a method to detect breast cancer from urine samples using dog sniffing in the diagnosis of breast cancer. Although the methodological standardization is still an issue to be discussed, the current result warrants further study for developing a new breast cancer screening method based on volatile organic compounds in urine samples.

scholarly journals Cyanuric Chloride Containing Chalcones for Possible Breast Cancer Treatment: Synthesis, Antimicrobial and in silico Screening

2019 ◽  
Vol 32 (2) ◽  
pp. 408-414
Author(s):  
Revathy Selvaraj ◽  
J. Suresh ◽  
A. Arun
Keyword(s):  
Breast Cancer ◽  
In Silico ◽  
Topoisomerase Ii ◽  
Excellent Result ◽  
Screening Method ◽  
Cyanuric Chloride ◽  
Gram Negative Bacteria ◽  
In Silico Screening ◽  
Gram Negative ◽  
Mic Value

In this work, we have synthesized efficient antibacterial compounds with anticancer novel molecules based on cyanuric chloride containing chalcone moiety. For this, novel triazine-based organic molecules were synthesized by using cyanuric chloride and 2,4-dichloro-1-ene(4-hydroxyphenyl)phenone and characterized by elemental analysis, FT-IR, NMR and UV-visible spectrometry techniques. Melting point of the molecules were increased with an increase in substitution on cyanuric chloride. The minimum inhibitory concentration (MIC) value of the synthesized compounds showed an excellent result on Gram-negative bacteria with low MIC value of 1.95 μg/mL. Gram-positive bacteria showed little resistance to the synthesized drug. The synthesized compounds were tested for their use as an anticancer drug using in silico screening method. The synthesized compounds in silico molecular docking method using breast cancer protein (BRCA2) confirms that triazine derivative with all three chlorine molecules replaced by 2,4-dichloro-1-ene(4-hydroxyphenyl)phenone showed highest binding energy with the value of -9.1900 Kcal/mol which is in agreement with the observed high MIC value obtained for Gram-negative bacteria. The synthesized molecules preferentially targeted the topoisomerase II of the bacteria. Overall, an efficient antimicrobial drug is synthesized using a simple preparation method.

Sign in / Sign up

Export Citation Format

Share Document