Brain tumor magnetic targeting and biodistribution of superparamagnetic iron oxide nanoparticles linked with 70-kDa heat shock protein study by nonlinear longitudinal response

AbstractThe purpose of this study was to review the use of the magnetic targeting technique, characterized by magnetic driving compounds based on superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery for a specific brain locus in gliomas. We reviewed a process mediated by the application of an external static magnetic field for targeting SPIONs in gliomas. A search of PubMed, Cochrane Library, Scopus, and Web of Science databases identified 228 studies, 23 of which were selected based on inclusion criteria and predetermined exclusion criteria. The articles were analyzed by physicochemical characteristics of SPIONs used, cell types used for tumor induction, characteristics of experimental glioma models, magnetic targeting technical parameters, and analysis method of process efficiency. The study shows the highlights and importance of magnetic targeting to optimize the magnetic targeting process as a therapeutic strategy for gliomas. Regardless of the intensity of the patterned magnetic field, the time of application of the field, and nanoparticle used (commercial or synthesized), all studies showed a vast advantage in the use of magnetic targeting, either alone or in combination with other techniques, for optimized glioma therapy. Therefore, this review elucidates the preclinical and therapeutic applications of magnetic targeting in glioma, an innovative nanobiotechnological method.

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Magnetic Targeting of Human Mesenchymal Stem Cells with Internalized Superparamagnetic Iron Oxide Nanoparticles

Small ◽

10.1002/smll.201300570 ◽

2013 ◽

Vol 9 (23) ◽

pp. 4017-4026 ◽

Cited By ~ 59

Author(s):

Natalia Landázuri ◽

Sheng Tong ◽

Jin Suo ◽

Giji Joseph ◽

Daiana Weiss ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Human Mesenchymal Stem Cells ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Magnetic Targeting

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Magnetic targeting with superparamagnetic iron oxide nanoparticles for in vivo glioma

nano Online ◽

10.1515/nano.0034.00126 ◽

2018 ◽

Author(s):

Marina Fontes de Paula Aguiar ◽

Javier Bustamante Mamani ◽

Taylla Klei Felix ◽

Rafael Ferreira dos Reis ◽

Helio Rodrigues da Silva ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Magnetic Targeting

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Gold-Coated Superparamagnetic Iron Oxide Nanoparticles Attenuate Collagen-Induced Arthritis after Magnetic Targeting

Biological Trace Element Research ◽

10.1007/s12011-019-01799-z ◽

2019 ◽

Vol 194 (2) ◽

pp. 502-513 ◽

Cited By ~ 6

Author(s):

Maria Fernanda Hornos Carneiro ◽

Ana Rita T. Machado ◽

Lusânia M. G. Antunes ◽

Talita E. Souza ◽

Victor A. Freitas ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Magnetic Targeting ◽

Collagen Induced Arthritis

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Ultrasmall cationic superparamagnetic iron oxide nanoparticles as nontoxic and efficient MRI contrast agent and magnetic-targeting tool

International Journal of Nanomedicine ◽

10.2147/ijn.s83150 ◽

2015 ◽

pp. 4731 ◽

Cited By ~ 7

Author(s):

Koiti Araki ◽

Mayara Uchiyama ◽

Sergio Toma ◽

Stephen Rodrigues ◽

Ana Shimada ◽

...

Keyword(s):

Iron Oxide ◽

Contrast Agent ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Mri Contrast Agent ◽

Oxide Nanoparticles ◽

Magnetic Targeting ◽

Mri Contrast

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Magnetic targeting of surface-modified superparamagnetic iron oxide nanoparticles yields antibacterial efficacy against biofilms of gentamicin-resistant staphylococci

Acta Biomaterialia ◽

10.1016/j.actbio.2012.03.002 ◽

2012 ◽

Vol 8 (6) ◽

pp. 2047-2055 ◽

Cited By ~ 95

Author(s):

Guruprakash Subbiahdoss ◽

Shahriar Sharifi ◽

Dirk W. Grijpma ◽

Sophie Laurent ◽

Henny C. van der Mei ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Magnetic Targeting ◽

Antibacterial Efficacy ◽

Surface Modified

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Superparamagnetic iron oxide nanoparticles functionalized with a binary alkoxysilane array and poly(4-vinylpyridine) for magnetic targeting and pH-responsive release of doxorubicin

New Journal of Chemistry ◽

10.1039/d0nj05227b ◽

2021 ◽

Vol 45 (7) ◽

pp. 3600-3609

Author(s):

Fernando Espinola-Portilla ◽

Oracio Serrano-Torres ◽

Gilberto F. Hurtado-López ◽

Uriel Sierra ◽

Anne Varenne ◽

...

Keyword(s):

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Ph Sensitive ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Magnetic Targeting ◽

Ph Responsive ◽

Novel Therapeutic

The reported supramolecular arrangement offers an attractive strategy for the pH-sensitive and magnetically-guided release of doxorubicin, which could allow exploring novel therapeutic schemes against cancer.

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