Longer dinucleotide repeat polymorphism in matrix metalloproteinase-9 (MMP-9) gene promoter which correlates with higher HTLV-I Tax mediated transcriptional activity influences the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP)

2004 ◽  
Vol 156 (1-2) ◽  
pp. 188-194 ◽  
Author(s):  
Daisuke Kodama ◽  
Mineki Saito ◽  
Wataru Matsumoto ◽  
Amir H. Sabouri ◽  
Shuji Izumo ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Transcriptional Activity ◽  
Spastic Paraparesis ◽  
Gene Promoter ◽  
Matrix Metalloproteinase 9 ◽  
Dinucleotide Repeat ◽  
Tropical Spastic Paraparesis ◽  
Repeat Polymorphism ◽  
Dinucleotide Repeat Polymorphism ◽  
Metalloproteinase 9

Association Study between Functional Polymorphisms of MMP9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population

2020 ◽  
Author(s):  
Sima SABBAGH ◽  
Zakiye NADEALI ◽  
Vahid SHAYGANNEJAD ◽  
Majid REZVANI ◽  
Masih SABOORI ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Matrix Metalloproteinase ◽  
Gene Polymorphisms ◽  
Transcriptional Activity ◽  
Gene Promoter ◽  
Functional Polymorphisms ◽  
Multiple Sclerosis Susceptibility ◽  
Metalloproteinase 9 ◽  
Mmp9 Gene ◽  
Ms Therapy

Background: Matrix metalloproteinase-9 (MMP-9) polymorphisms, C−1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of MMP-9 polymorphisms in Iranian MS patients is studied. Methods: Association of MMP-9 mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017. Results: -1562 T allele of MMP-9 was associated with increased MS risk. However, we found no overall significant effect of −90 (CA)n repeat on MS susceptibility. Conclusion: For as much as MMP-9 molecule is a potential target for MS therapy, to determine whether any of MMP-9 polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA repeats, further research is needed before proposing any definite conclusion.

scholarly journals α-Lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-κB transcriptional activity

2007 ◽  
Vol 39 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Hye-Soon Kim ◽  
Hye-Jin Kim ◽  
Keun-Gyu Park ◽  
Yoon-Nyun Kim ◽  
Taeg-Kyu Kwon ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Lipoic Acid ◽  
Transcriptional Activity ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9
Sign in / Sign up

Export Citation Format

Share Document