Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid have less global and regional brain atrophy

OBJECTIVE: To determine if the presence of oligoclonal bands (OB) at early stages of multiple sclerosis was associated with higher brain atrophy, when compared with patients without OB. METHODS: Relapsing-remitting multiple sclerosis (RRMS) patients with less than two years of disease onset and OB detection in cerebrospinal fluid (CSF) were included. SIENAX was used for total brain volume (TBV), gray matter volume (GMV), and white matter volume (WMV). RESULTS: Forty patients were included, 29 had positive IgG-OB. No differences were found between positive and negative patients in gender, expanded disability status scale (EDSS), treatment received, and T2/T1 lesion load. TBV in positive IgG-OB patients was 1.5 mm³ x 10(6) compared with 1.64 mm³ x 10(6) in the negative ones (p=0.02). GMV was 0.51 mm³ x 10(6) in positive IgG-OB compared with 0.62 mm³ x 10(6) in negative ones (p=0.002). No differences in WMV (p=0.09) were seen. CONCLUSIONS: IgG-OB in the CSF was related to neurodegeneration magnetic resonance (MR) markers in early RRMS.

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Evolution of regional brain atrophy in children with multiple sclerosis

Neurology ◽

10.1212/wnl.0000000000007254 ◽

2019 ◽

Vol 92 (15) ◽

pp. 694-695 ◽

Cited By ~ 2

Author(s):

E. Ann Yeh ◽

Arman Eshaghi

Keyword(s):

Multiple Sclerosis ◽

Brain Atrophy ◽

Regional Brain ◽

Regional Brain Atrophy

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Optic nerve atrophy and whole and regional brain atrophy in Leber's hereditary optic neuropathy with multiple sclerosis-like disease with m.11778G>A mutation

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2020.102071 ◽

2020 ◽

Vol 42 ◽

pp. 102071 ◽

Cited By ~ 1

Author(s):

Iwona Rościszewska-Żukowska ◽

Halina Bartosik-Psujek

Keyword(s):

Multiple Sclerosis ◽

Optic Nerve ◽

Optic Neuropathy ◽

Brain Atrophy ◽

Leber’S Hereditary Optic Neuropathy ◽

Leber's Hereditary Optic Neuropathy ◽

Optic Nerve Atrophy ◽

Regional Brain ◽

Regional Brain Atrophy ◽

Hereditary Optic Neuropathy

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Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study

Multiple Sclerosis Journal ◽

10.1177/1352458514538111 ◽

2014 ◽

Vol 20 (14) ◽

pp. 1900-1903 ◽

Cited By ~ 27

Author(s):

R Mancuso ◽

D Franciotta ◽

M Rovaris ◽

D Caputo ◽

A Sala ◽

...

Keyword(s):

Multiple Sclerosis ◽

Cerebrospinal Fluid ◽

Longitudinal Study ◽

Retrospective Studies ◽

Oligoclonal Bands ◽

Igg Index ◽

Before And After ◽

Oligoclonal Igg ◽

Multiple Sclerosis Patients

Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before and after 2 years of natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance of the OCBs in CSF samples that were taken after 2 years of therapy. Intrathecal IgG production, represented by the IgG index and IgGLoc, was also quantitatively reduced. Our data showed that natalizumab substantially modulates both intrathecal polyclonal and oligoclonal IgG production: This effect was much more potent than was previously reported.

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Disappearance of cerebrospinal fluid oligoclonal bands after natalizumab treatment of multiple sclerosis patients

Multiple Sclerosis Journal ◽

10.1177/1352458511428465 ◽

2011 ◽

Vol 18 (7) ◽

pp. 1038-1041 ◽

Cited By ~ 35

Author(s):

Felipe von Glehn ◽

Alessandro S Farias ◽

Augusto C Penalva de Oliveira ◽

Alfredo Damasceno ◽

Ana Leda F Longhini ◽

...

Keyword(s):

Multiple Sclerosis ◽

Central Nervous System ◽

Cerebrospinal Fluid ◽

Nervous System ◽

Oligoclonal Bands ◽

Natalizumab Treatment ◽

The Central Nervous System ◽

Immunologic Abnormality ◽

Csf Oligoclonal Bands ◽

Multiple Sclerosis Patients

Intrathecal immunoglobulin synthesis in an oligoclonal pattern is the most common immunologic abnormality detected in MS patients. Various treatments, such as immunomodulators and immunosuppressors, have not been found to modify it. Natalizumab hinders migration of encephalitogenic T-cells into the central nervous system (CNS), reducing inflammatory response. Its impact on CSF oligoclonal bands (OCBs) has not been demonstrated. This report describes its effect in four out of six patients with multiple sclerosis after a mean of 10 infusions: the CSF was negative for OCBs at the second lumbar puncture. In conclusion, natalizumab treatment can reduce CSF OCBs to undetectable levels, although the clinical significance of this observation is not yet known.

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Regional Brain Atrophy and Functional Connectivity Changes Related to Fatigue in Multiple Sclerosis

PLoS ONE ◽

10.1371/journal.pone.0077914 ◽

2013 ◽

Vol 8 (10) ◽

pp. e77914 ◽

Cited By ~ 39

Author(s):

Álvaro Javier Cruz Gómez ◽

Noelia Ventura Campos ◽

Antonio Belenguer ◽

César Ávila ◽

Cristina Forn

Keyword(s):

Multiple Sclerosis ◽

Functional Connectivity ◽

Brain Atrophy ◽

Regional Brain ◽

Regional Brain Atrophy

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Oligoclonal bands in cerebrospinal fluid detected by PhastSystem isoelectric focusing

Clinical Chemistry ◽

10.1093/clinchem/36.1.123 ◽

1990 ◽

Vol 36 (1) ◽

pp. 123-125 ◽

Cited By ~ 8

Author(s):

I Wybo ◽

M Van Blerk ◽

R Malfait ◽

P Goubert ◽

F Gorus

Keyword(s):

Multiple Sclerosis ◽

Central Nervous System ◽

Cerebrospinal Fluid ◽

Isoelectric Focusing ◽

Protein Electrophoresis ◽

Oligoclonal Bands ◽

Agarose Gels ◽

Oligoclonal Banding ◽

The Central Nervous System ◽

Multiple Sclerosis Patients

Abstract Pharmacia's "PhastSystem" for semi-automated isoelectric focusing (IEF) in thin precast polyacrylamide gels (PAGE) was found to be as sensitive as high-resolution protein electrophoresis (HRPE) in agarose gels and conventional PAGE-IEF for detection of oligoclonal banding (OB) in concentrated cerebrospinal fluid (CSF) samples. Both PhastSystem IEF and HRPE revealed OB in CSF from eight of nine multiple sclerosis patients and four of 10 patients with various types of infection of the central nervous system as opposed to only two of 70 patients with miscellaneous neuropsychiatric disorders. The PhastSystem also frequently detected OB in silver-stained, unconcentrated CSF from patients with multiple sclerosis.

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