A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients

2016 ◽  
Vol 292 ◽  
pp. 34-39 ◽  
Author(s):  
Serena Martire ◽  
Nicole D. Navone ◽  
Francesca Montarolo ◽  
Simona Perga ◽  
Antonio Bertolotto
Keyword(s):  
Gene Expression ◽  
Multiple Sclerosis ◽  
Treatment Response ◽  
Interferon Beta ◽  
Gene Expression Study ◽  
Expression Study ◽  
Multiple Sclerosis Patients

scholarly journals Clinical response to interferon beta and glatiramer acetate in multiple sclerosis patients: a Brazilian cohort

2012 ◽  
Vol 70 (10) ◽  
pp. 774-779 ◽  
Author(s):  
Valéria Coelho Santa Rita Pereira ◽  
Fabíola Rachid Malfetano ◽  
Isabella D'Andrea Meira ◽  
Letícia Fêzer de Souza ◽  
Assuncion Martinez Liem ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Response ◽  
Treatment Response ◽  
Glatiramer Acetate ◽  
Interferon Beta ◽  
Response To Treatment ◽  
Clinical Criteria ◽  
Significant Difference ◽  
One Year ◽  
Multiple Sclerosis Patients

INTRODUCTION: Many patients with multiple sclerosis (MS) are currently receiving treatment with interferon beta (IFNb) and glatiramer acetate (GA). Identifying nonresponders patients is important to define therapy strategies. Several criteria for treatment response to IFNb and GA have been proposed. OBJECTIVE: It was to investigate the response to treatment with IFNb-1a, IFNb-1b and GA among relapsing-remitting multiple sclerosis (RRMS) patients. METHODS: We analyzed treatment response to IFNb and GA in ninety-one RRMS patients followed for at least one year. Clinical response was established by clinical criteria based on relapses, disability progression or both. RESULTS: We observed a proportion of nonresponders, ranging from 3.3 to 42.9%, depending on the stringency of the criteria used. CONCLUSIONS: Our sample of Brazilian patients with MS has similarities when compared to other studies and there was no statistically significant difference regarding age, gender, ethnicity or disease duration between responders and nonresponders.

scholarly journals Anti-inflammatory genes associated with multiple sclerosis: A gene expression study

2015 ◽  
Vol 279 ◽  
pp. 75-78 ◽  
Author(s):  
S. Perga ◽  
F. Montarolo ◽  
S. Martire ◽  
P. Berchialla ◽  
S. Malucchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Multiple Sclerosis ◽  
Gene Expression Study ◽  
Expression Study ◽  
Inflammatory Genes ◽  
Anti Inflammatory

scholarly journals Baseline Gene Expression Signatures in Monocytes from Multiple Sclerosis Patients Treated with Interferon-beta

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e60994 ◽  
Author(s):  
Marta F. Bustamante ◽  
Ramil N. Nurtdinov ◽  
Jordi Río ◽  
Xavier Montalban ◽  
Manuel Comabella
Keyword(s):  
Gene Expression ◽  
Multiple Sclerosis ◽  
Interferon Beta ◽  
Gene Expression Signatures ◽  
Multiple Sclerosis Patients

Comparative gene expression study in WM164 melanoma cells treated with dimethylacrylshikonin.

2017 ◽  
Author(s):  
N Kretschmer ◽  
A Deutsch ◽  
B Rinner ◽  
M Scheideler ◽  
R Bauer
Keyword(s):  
Gene Expression ◽  
Melanoma Cells ◽  
Gene Expression Study ◽  
Expression Study
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