Tau deposition and microglial activation in the living brain of early-stage Alzheimer disease

2017 ◽  
Vol 381 ◽  
pp. 127-128
Author(s):  
T. Terada ◽  
T. Bunai ◽  
T. Matsudaira ◽  
Y. Araki ◽  
A. Sugiura ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Microglial Activation ◽  
Early Stage

A novel biomarker to detect early-stage Alzheimer disease

2011 ◽  
Vol 7 (8) ◽  
pp. 420-420 ◽  
Author(s):  
Katy Malpass
Keyword(s):  
Alzheimer Disease ◽  
Early Stage

scholarly journals CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

2011 ◽  
Vol 286 (37) ◽  
pp. 32713-32722 ◽  
Author(s):  
Seo-Hyun Cho ◽  
Binggui Sun ◽  
Yungui Zhou ◽  
Tiina M. Kauppinen ◽  
Brian Halabisky ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Mouse Model ◽  
Cognitive Deficits ◽  
Microglial Activation ◽  
Protein Signaling

scholarly journals Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage

2016 ◽  
Vol 80 (2) ◽  
pp. 301-306 ◽  
Author(s):  
Jake G. Hoekstra ◽  
Michael J. Hipp ◽  
Thomas J. Montine ◽  
Scott R. Kennedy
Keyword(s):  
Mitochondrial Dna ◽  
Alzheimer Disease ◽  
Oxidative Damage ◽  
Early Stage ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations

scholarly journals [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy

Neurology ◽  
2018 ◽  
Vol 90 (22) ◽  
pp. e1989-e1996 ◽  
Author(s):  
Luca Passamonti ◽  
Patricia Vázquez Rodríguez ◽  
Young T. Hong ◽  
Kieren S.J. Allinson ◽  
W. Richard Bevan-Jones ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Progressive Supranuclear Palsy ◽  
Medial Temporal Lobe ◽  
Microglial Activation ◽  
Case Control Study ◽  
Pet Scanning ◽  
Study Participants ◽  
Parietal Cortices ◽  
Control Study

ObjectiveWe tested whether in vivo neuroinflammation relates to the distinctive distributions of pathology in Alzheimer disease (AD) and progressive supranuclear palsy (PSP).MethodsSixteen patients with symptomatic AD (including amnestic mild cognitive impairment with amyloid-positive PET scan), 16 patients with PSP–Richardson syndrome, and 13 age-, sex-, and education-matched healthy controls were included in this case-control study. Participants underwent [11C]PK11195 PET scanning, which was used as an in vivo index of neuroinflammation.Results[11C]PK11195 binding in the medial temporal lobe and occipital, temporal, and parietal cortices was increased in patients with AD, relative both to patients with PSP and to controls. Compared to controls, patients with PSP showed elevated [11C]PK11195 binding in the thalamus, putamen, and pallidum. [11C]PK11195 binding in the cuneus/precuneus correlated with episodic memory impairment in AD, while [11C]PK11195 binding in the pallidum, midbrain, and pons correlated with disease severity in PSP.ConclusionsTogether, our results suggest that neuroinflammation has an important pathogenic role in the 2 very different human neurodegenerative disorders of AD and PSP. The increase and distribution of microglial activation suggest that immunotherapeutic strategies may be useful in slowing the progression of both diseases.

scholarly journals Association of epileptiform abnormalities and seizures in Alzheimer disease

Neurology ◽  
2020 ◽  
Vol 95 (16) ◽  
pp. e2259-e2270 ◽  
Author(s):  
Alice D. Lam ◽  
Rani A. Sarkis ◽  
Kyle R. Pellerin ◽  
Jin Jing ◽  
Barbara A. Dworetzky ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Late Onset ◽  
Early Stage ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Cognitively Normal ◽  
Scalp Eeg ◽  
Epileptiform Discharges ◽  
Potential Biomarker ◽  
The Relationship

ObjectiveTo examine the relationship between scalp EEG biomarkers of hyperexcitability in Alzheimer disease (AD) and to determine how these electric biomarkers relate to the clinical expression of seizures in AD.MethodsIn this cross-sectional study, we performed 24-hour ambulatory scalp EEGs on 43 cognitively normal elderly healthy controls (HC), 41 participants with early-stage AD with no history or risk factors for epilepsy (AD-NoEp), and 15 participants with early-stage AD with late-onset epilepsy related to AD (AD-Ep). Two epileptologists blinded to diagnosis visually reviewed all EEGs and annotated all potential epileptiform abnormalities. A panel of 9 epileptologists blinded to diagnosis was then surveyed to generate a consensus interpretation of epileptiform abnormalities in each EEG.ResultsEpileptiform abnormalities were seen in 53% of AD-Ep, 22% of AD-NoEp, and 4.7% of HC. Specific features of epileptiform discharges, including high frequency, robust morphology, right temporal location, and occurrence during wakefulness and REM, were associated with clinical seizures in AD. Multiple EEG biomarkers concordantly demonstrated a pattern of left temporal lobe hyperexcitability in early stages of AD, whereas clinical seizures in AD were often associated with bitemporal hyperexcitability. Frequent small sharp spikes were specifically associated with epileptiform EEGs and thus identified as a potential biomarker of hyperexcitability in AD.ConclusionEpileptiform abnormalities are common in AD but not all equivalent. Specific features of epileptiform discharges are associated with clinical seizures in AD. Given the difficulty recognizing clinical seizures in AD, these EEG features could provide guidance on which patients with AD are at high risk for clinical seizures.

scholarly journals The Physical Performance Test Predicts Aerobic Capacity Sufficient for Independence in Early-Stage Alzheimer Disease

2012 ◽  
Vol 35 (2) ◽  
pp. 72-78 ◽  
Author(s):  
Eric D. Vidoni ◽  
Sandra A. Billinger ◽  
Charesa Lee ◽  
Jenna Hamilton ◽  
Jeffrey M. Burns
Keyword(s):  
Alzheimer Disease ◽  
Physical Performance ◽  
Aerobic Capacity ◽  
Performance Test ◽  
Early Stage ◽  
Physical Performance Test

scholarly journals Aerobic Exercise Sustains Performance of Instrumental Activities of Daily Living in Early-Stage Alzheimer Disease

2019 ◽  
Vol 42 (3) ◽  
pp. E129-E134 ◽  
Author(s):  
Eric D. Vidoni ◽  
Jaime Perales ◽  
Mohammed Alshehri ◽  
Abdul-Mannaan Giles ◽  
Catherine F. Siengsukon ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Activities Of Daily Living ◽  
Aerobic Exercise ◽  
Daily Living ◽  
Early Stage ◽  
Instrumental Activities

Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease

2008 ◽  
Vol 202 (1-3) ◽  
pp. 37-51 ◽  
Author(s):  
Evelin L. Schaeffer ◽  
Orestes V. Forlenza ◽  
Wagner F. Gattaz
Keyword(s):  
Alzheimer Disease ◽  
Phospholipase A2 ◽  
Therapeutic Approach ◽  
Cognitive Enhancement ◽  
Early Stage

Mild Cognitive Impairment Is Early-Stage Alzheimer Disease

2006 ◽  
Vol 63 (1) ◽  
pp. 15 ◽  
Author(s):  
John C. Morris
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Alzheimer Disease ◽  
Early Stage

P2-378: MALE PATIENTS WITH EARLY STAGE ALZHEIMER DISEASE HAVE STRESS IN HOSPITAL

2014 ◽  
Vol 10 ◽  
pp. P616-P617
Author(s):  
Yumi Umeda-Kameyama ◽  
Katsuya Iijima ◽  
Kiyoshi Yamaguchi ◽  
Kiwami Kidana ◽  
Masayuki Honda ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Early Stage ◽  
Male Patients
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