Vitamin D levels influence radiological and laboratory outcomes of multiple sclerosis patients treated with Ocrelizumab

2021 ◽  
Vol 429 ◽  
pp. 118087
Author(s):  
Giuseppina Miele ◽  
Gianmarco Abbadessa ◽  
Antonio De Martino ◽  
Paola Valentino ◽  
Girolama Marfia ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Vitamin D Levels ◽  
Multiple Sclerosis Patients

scholarly journals Comparison of Antioxidant Status and Vitamin D Levels between Multiple Sclerosis Patients and Healthy Matched Subjects

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Ehsan Hejazi ◽  
Reza Amani ◽  
Naser SharafodinZadeh ◽  
Bahman Cheraghian
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Dietary Intake ◽  
Antioxidant Status ◽  
Sun Exposure ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Study Groups ◽  
Vitamin D Levels ◽  
Multiple Sclerosis Patients

Objective. The aim of the present study was to compare the serum levels of total antioxidant status (TAS) and 25(OH) D3 and dietary intake of multiple sclerosis (MS) patients with those of normal subjects.Method. Thirty-seven MS patients (31 women) and the same number of healthy matched controls were compared for their serum levels and dietary intake of 25(OH) D3 and TAS. Sun exposure and the intake of antioxidants and vitamin D rich foods were estimated through face-to-face interview and food frequency questionnaire.Results. Dietary intake of antioxidants and vitamin D rich foods, vitamin C, vitamin A, and folate was not significantly different between the two groups. There were also no significant differences in the mean levels of 25(OH) D3 and TAS between the study groups. Both groups had low serum levels of 25(OH) D3 and total antioxidants.Conclusion. No significant differences were detected in serum levels and dietary intake of vitamin D and antioxidants between MS patients and healthy controls. All subjects had low antioxidant status and vitamin D levels.

KLOTO rs1207588 allelic variant affects serum vitamin D levels in multiple sclerosis patients

2019 ◽  
Vol 493 ◽  
pp. S614
Author(s):  
L. Agnello ◽  
C. Scazzone ◽  
B. Lo Sasso ◽  
G. Bivona ◽  
G. Iacolino ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Allelic Variant ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Multiple Sclerosis Patients

scholarly journals Inflammatory activity and vitamin D levels in an MS population treated with rituximab

2019 ◽  
Vol 5 (1) ◽  
pp. 205521731982659 ◽  
Author(s):  
Johan Linden ◽  
Gabriel Granåsen ◽  
Jonatan Salzer ◽  
Anders Svenningsson ◽  
Peter Sundström
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Magnetic Resonance ◽  
Vitamin D Supplementation ◽  
Inflammatory Activity ◽  
T2 Lesions ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Multiple Sclerosis Patients

Background Most multiple sclerosis patients on disease-modifying treatment at Umeå University Hospital are treated with rituximab and the prevalence of vitamin D supplementation has increased over time. Follow-up studies of these off-label treatments are needed. Objective To study inflammatory activity and adverse effects in rituximab-treated multiple sclerosis patients, and associations with 25-hydroxy-vitamin D levels. Methods Retrospectively collected data on repeated estimates of relapses, disability, side effects, magnetic resonance imaging, laboratory measures including 25-hydroxy-vitamin D levels and self-perceived health. Results In 272 multiple sclerosis patients with a mean follow-up of 43 months, we identified seven possible relapses during active rituximab treatment. On magnetic resonance imaging examination, new T2 lesions were seen in 1.3% (10 out of 792 scans), and 0.25% (two out of 785 scans) showed contrast enhancement. Adjusted 25-hydroxy-vitamin D levels in samples drawn close to all magnetic resonance images with new T2 lesions were lower compared to the remainder (62 vs. 81 nmol/l; P = 0.030). Levels of 25-hydroxy-vitamin D were associated with self-perceived health ( r = 0.18, P = 0.041, n = 130) and C-reactive protein ( r = –0.13, P = 0.042) but not with the risk of side effects. Conclusion The inflammatory activity in this rituximab-treated multiple sclerosis population that increasingly used vitamin D supplementation was extremely low. Higher 25-hydroxy-vitamin D levels were associated with beneficial outcomes.

Vitamin D levels in multiple sclerosis patients: Association with TGF-β2, TGF-βRI, and TGF-βRII expression

Life Sciences ◽  
2015 ◽  
Vol 134 ◽  
pp. 63-67 ◽  
Author(s):  
Zeinab Shirvani-Farsani ◽  
Mehrdad Behmanesh ◽  
Seyed Mahdi Mohammadi ◽  
Abdorreza Naser Moghadasi
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Vitamin D Levels ◽  
Multiple Sclerosis Patients

Basal vitamin D levels and disease activity in multiple sclerosis patients treated with fingolimod

2018 ◽  
Vol 39 (8) ◽  
pp. 1467-1470 ◽  
Author(s):  
L. Ferre’ ◽  
F. Clarelli ◽  
G. Sferruzza ◽  
M. A. Rocca ◽  
E. Mascia ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Disease Activity ◽  
Vitamin D Levels ◽  
Multiple Sclerosis Patients

scholarly journals Association between age at onset of multiple sclerosis and vitamin D level in Saudi population

2019 ◽  
Vol 6 (9) ◽  
pp. 3728
Author(s):  
Hossam H. Younis ◽  
Abdulrahman H. Alzahrani ◽  
Abdulmageed S. Alomar
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Age At Onset ◽  
High Rate ◽  
Military Hospital ◽  
P Value ◽  
Healthy Controls ◽  
Saudi Population ◽  
Vitamin D Levels ◽  
Multiple Sclerosis Patients

Background: Several studies have shown an association between 25-hydroxyvitamin D (Vitamin D) levels and multiple sclerosis (MS). This study aimed to evaluate association between age at onset of Multiple Sclerosis and vitamin D level in Saudi population.Methods: This cross-sectional study was performed in the Neurology Department king Fahd Military Hospital Jeddah in the Kingdom of Saudi Arabia (KSA) included 75 patients with MS and 99 healthy controls group matched for gender and age. Comparing vitamin D measurement in multiple sclerosis patients at the time of diagnosis with healthy controls group.Results: We found no significant association between age at onset of multiple sclerosis and vitamin D level in Saudi population p value (0.723). However we also found that 74.66% of the sample Members who had MS and has a deficient of vitamin D and 83.83% people of the sample members didn’t have MS, but vitamin D was deficient with them.Conclusions: Study has revealed a high rate of vitamin D deficiency in patients with MS and in the controls group, as well Therese no clear relation to MS, Thus Therese no significant association between age at onset of multiple sclerosis and vitamin D level in Saudi population.

Vitamin D levels in pediatric Multiple Sclerosis patients

2011 ◽  
Vol 42 (S 01) ◽  
Author(s):  
A Blaschek ◽  
T Langhagen ◽  
S Bechtold-Dalla Pozza ◽  
F Heinen ◽  
W Müller-Felber
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Pediatric Multiple Sclerosis ◽  
Vitamin D Levels ◽  
Multiple Sclerosis Patients

VITAMIN D LEVELS, VITAMIN D INTAKE AND SUNLIGHT EXPOSURE IN PEDIATRIC MULTIPLE SCLEROSIS

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
R Hung ◽  
R Vieth ◽  
R Goldman ◽  
E Sochett ◽  
B Banwell
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Sunlight Exposure ◽  
Pediatric Multiple Sclerosis ◽  
Vitamin D Intake ◽  
Vitamin D Levels

scholarly journals Reduction in circulating vitamin D binding protein in patients with multiple sclerosis

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhila Maghbooli ◽  
Abolfazl Omidifar ◽  
Tarlan Varzandi ◽  
Tayebeh Salehnezhad ◽  
Mohammad Ali Sahraian
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Binding Protein ◽  
Serum Levels ◽  
Causative Role ◽  
Vitamin D Binding Protein ◽  
Control Groups ◽  
Current Case ◽  
Vitamin D Levels ◽  
And Control

Abstract Background In this study, we aimed to determine the risk association between vitamin D binding protein (VDBP) polymorphism in patients with multiple sclerosis (MS) in a MS biobank and the difference in VDBP serum levels in MS patients who were recently diagnosed. Method The current case-control study was performed on 296 MS patients and 313 controls. Thereafter, two common missense VDBP polymorphisms, named rs7041and rs4588, were evaluated in all the participants. Serum levels of vitamin D and vitamin D binding protein were assessed in 77 MS patients who were diagnosed since one year ago and in 67 healthy people who were matched in terms of age and sex. Result The frequency distributions of VDBP genotypes and alleles of SNP rs7041 and rs4588 were observed to be similar in both the MS and control groups (p > 0.05). The VDBP haplotypes, as Gc2/Gc2, Gc1/Gc1, and Gc1/Gc2, were found to be similar in the MS and control groups (p > 0.05). In subgroup analysis, circulating VDBP was lower in MS patients (Ln-VDBP (μgr/ml): 3.64 ± 0.91 vs. 5.31 ± 0.77, p = 0.0001) even after adjusting for vitamin D levels, body mass index, and taking vitamin D supplement. There was no significant association between VDBP haplotypes and vitamin D levels in the two groups. Conclusion The present study suggested an association between lower levels of circulating VDBP and multiple sclerosis in newly diagnosed patients. However, the VDBP causative role in the development of MS is still unclear, so it needs more studies.

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