Objective:
To summarize the main findings on nutraceuticals that slow aging processes by
delaying and even preventing the development of multiple chronic diseases and improve productivity and
quality of life in the elderly.
Methods:
Literature search of the relevant papers known to the authors was conducted.
Results:
The most robust environmental manipulation for extending lifespan is caloric restriction without
malnutrition. Some nutraceuticals can mimic caloric restriction effects. This review will focus on the
nutraceuticals that impact insulin-like growth factor 1 receptor signaling and sirtuin activity in mediating
longevity and healthspan.
Conclusion:
Aging is considered to be synonymous with the appearance of major diseases and an overall
decline in physical and mental performance. Caloric restriction is well established as a strategy to extend
lifespan without malnutrition. A variety of nutraceuticals were reported to mimic the effect of caloric
restriction by modulating the activity of insulin-like growth factor 1 receptor signaling and sirtuin activity
and consequently promote longevity and healthspan.
Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy