γ-Tocotrienol-induced disruption of lipid rafts in human breast cancer cells is associated with a reduction in exosome heregulin content

2017 ◽  
Vol 48 ◽  
pp. 83-93 ◽  
Author(s):  
Osama A. Alawin ◽  
Rayan A. Ahmed ◽  
Venkateshwararao Dronamraju ◽  
Karen P. Briski ◽  
Paul W. Sylvester
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Lipid Rafts ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Hari Raghu ◽  
Prasanna Kumar Sodadasu ◽  
Rama Rao Malla ◽  
Christopher S Gondi ◽  
Norman Estes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Lipid Rafts ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells

FEBS Letters ◽  
2005 ◽  
Vol 579 (28) ◽  
pp. 6343-6349 ◽  
Author(s):  
Daniela Sarnataro ◽  
Claudia Grimaldi ◽  
Simona Pisanti ◽  
Patrizia Gazzerro ◽  
Chiara Laezza ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Plasma Membrane ◽  
Cancer Cells ◽  
Lipid Rafts ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cannabinoid Receptor ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cb1 Cannabinoid Receptor

scholarly journals Increase in fatty acids and flotillins upon resveratrol treatment of human breast cancer cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Luciana Gomes ◽  
Marcos Sorgine ◽  
Carlos Luan Alves Passos ◽  
Christian Ferreira ◽  
Ivone Rosa de Andrade ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Lipid Rafts ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Resveratrol Treatment

Abstract Flotillin-1 and flotillin-2 are highly conserved proteins that localize into cholesterol-rich microdomains in cellular membranes. Flotillins are closely related to the occurrence and development of various types of human cancers. Flotillin-1 is highly expressed in breast cancer, and the high expression level of flotillin-1 is significantly correlated with poorer patient survival. Here we studied the relationship between the formation of lipid rafts and the expression of flotillins and lipids in human breast cancer cells. We used the polyphenol compound resveratrol to alter the structure and function of the plasma membrane. Our data revealed an increase in fatty acids in MCF-7 and MDA-MB-231 cells upon resveratrol treatment. Interestingly, we also found an increase in the expression of both flotillin-1 and flotillin-2 in breast tumor cells after treatment. Resveratrol also induced changes in the pattern of flotillin distribution among detergent-resistant lipid rafts fractions in both cell lines and induced the nuclear translocation of flotillin-2. Since resveratrol has been pointed out as a putative cancer therapy agent, our results could have an impact on the understanding of the effects of resveratrol in tumor cells.

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