Phase 1 studies of anti-interleukin-1 dual-variable domain immunoglobulin in healthy subjects and patients with osteoarthritis

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2015.02.735 ◽

2015 ◽

Vol 23 ◽

pp. A398-A399

Author(s):

S.X. Wang ◽

W. Liu ◽

P. Jiang ◽

M. Okun ◽

R.A. Preston ◽

...

Keyword(s):

Healthy Subjects ◽

Phase 1 ◽

Interleukin 1 ◽

Variable Domain ◽

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Pharmacokinetics and Tolerability of a Dual Variable Domain Immunoglobulin ABT-981 Against IL-1α and IL-1β in Healthy Subjects and Patients With Osteoarthritis of the Knee

The Journal of Clinical Pharmacology ◽

10.1002/jcph.764 ◽

2016 ◽

Vol 56 (12) ◽

pp. 1582-1590 ◽

Author(s):

Matthew P. Kosloski ◽

Sandra Goss ◽

Susanne X. Wang ◽

Jia Liu ◽

Ralf Loebbert ◽

...

Keyword(s):

Healthy Subjects ◽

Variable Domain ◽

Osteoarthritis Of The Knee ◽

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FRI0176 ABT-122, A Novel Dual Variable Domain (DVD)-IG™, Targeting TNF and IL-17, Inhibits Peripheral Blood Mononuclear Cell Production of GM-CSF and Decreases Lymphocyte Expression of CXCR4 in Healthy Subjects

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2015-eular.1544 ◽

2015 ◽

Vol 74 (Suppl 2) ◽

pp. 487.2-487 ◽

Author(s):

M. Ruzek ◽

D. Conlon ◽

H. Mansikka ◽

R.J. Padley ◽

C. Cuff

Keyword(s):

Peripheral Blood Mononuclear Cell ◽

Mononuclear Cell ◽

Peripheral Blood ◽

Healthy Subjects ◽

Variable Domain ◽

Dual Variable ◽

Peripheral Blood Mononuclear ◽

Cell Production ◽

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Pharmacokinetics of ABT-122, a TNF-α- and IL-17A-Targeted Dual-Variable Domain Immunoglobulin, in Healthy Subjects and Patients with Rheumatoid Arthritis: Results from Three Phase I Trials

Clinical Pharmacokinetics ◽

10.1007/s40262-017-0580-y ◽

2017 ◽

Vol 57 (5) ◽

pp. 613-623 ◽

Author(s):

Amit Khatri ◽

Sandra Goss ◽

Ping Jiang ◽

Heikki Mansikka ◽

Ahmed A. Othman

Keyword(s):

Rheumatoid Arthritis ◽

Phase I ◽

Healthy Subjects ◽

Variable Domain ◽

Phase I Trials ◽

Dual Variable ◽

Three Phase ◽

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Population Pharmacokinetics of the TNF-α and IL-17A Dual-Variable Domain Antibody ABT-122 in Healthy Volunteers and Subjects With Psoriatic or Rheumatoid Arthritis: Analysis of Phase 1 and 2 Clinical Trials

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1068 ◽

2018 ◽

Vol 58 (6) ◽

pp. 803-813 ◽

Author(s):

Amit Khatri ◽

Ahmed A. Othman

Keyword(s):

Rheumatoid Arthritis ◽

Clinical Trials ◽

Healthy Volunteers ◽

Population Pharmacokinetics ◽

Phase 1 ◽

Variable Domain ◽

Dual Variable ◽

Domain Antibody ◽

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Interleukin-1 dual variable domain immunoglobulin, a new potential treatment for osteoarthritis

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2014.02.881 ◽

2014 ◽

Vol 22 ◽

pp. S462-S463 ◽

Author(s):

S.X. Wang ◽

F. Berenbaum ◽

W.P. Maksymowych ◽

W. Liu ◽

M. Karunaratne ◽

...

Keyword(s):

Interleukin 1 ◽

Immunoglobulin A ◽

Variable Domain ◽

Potential Treatment ◽

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SAT0448 Interleukin-1 Dual Variable–Domain Immunoglobulin Reduces Multiple Imflammatory Markers in Knee Osteoarthritis Patients

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2014-eular.5528 ◽

2014 ◽

Vol 73 (Suppl 2) ◽

pp. 756.1-756 ◽

Author(s):

S.X. Wang ◽

J.K. Medema ◽

M.P. Kosloski ◽

W. Liu ◽

M.J. Saltarelli ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Interleukin 1 ◽

Variable Domain ◽

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THU0491 Dual Variable Domain-Immunoglobulin (DVD-IG™) ABT-981 Simultaneously and Dose-Dependently Inhibits Interleukin-1 Alpha and -1 Beta in Subjects with Knee Osteoarthritis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2015-eular.5091 ◽

2015 ◽

Vol 74 (Suppl 2) ◽

pp. 377.2-378

Author(s):

S.X. Wang ◽

R. Loebbert ◽

E.R. Sampson ◽

M.J. Saltarelli ◽

J.K. Medema ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Interleukin 1 ◽

Variable Domain ◽

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Phase 1, open-label, dose-escalation and expansion study of ABT-165, a dual variable domain immunoglobulin (DVD-Ig) targeting both DLL4 and VEGF, in patients (pts) with advanced solid tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.15_suppl.2507 ◽

2016 ◽

Vol 34 (15_suppl) ◽

pp. 2507-2507 ◽

Author(s):

Michael S. Gordon ◽

John J. Nemunaitis ◽

Ramesh K. Ramanathan ◽

George W. Sledge ◽

Lan Wang ◽

...

Keyword(s):

Solid Tumors ◽

Dose Escalation ◽

Phase 1 ◽

Variable Domain ◽

Advanced Solid Tumors ◽

Dual Variable ◽

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Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2017.09.007 ◽

2017 ◽

Vol 25 (12) ◽

pp. 1952-1961 ◽

Author(s):

S.X. Wang ◽

S.B. Abramson ◽

M. Attur ◽

M.A. Karsdal ◽

R.A. Preston ◽

...

Keyword(s):

Phase 1 ◽

Variable Domain ◽

Osteoarthritis Of The Knee ◽

Dual Variable ◽

Phase 1 Study ◽

Interleukin 1Α

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A Phase 1 Double-Blinded Study for Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of ATI-2173 in Healthy Subjects and Subjects With Chronic Hepatitis B Virus Infection

Case Medical Research ◽

10.31525/ct1-nct04248426 ◽

2020 ◽

Author(s):

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B Virus ◽

Virus Infection ◽

Healthy Subjects ◽

Phase 1 ◽

Hepatitis B Virus Infection ◽

Chronic Hepatitis B Virus ◽

B Virus ◽

Blinded Study ◽

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