scholarly journals Phase 1 studies of anti-interleukin-1 dual-variable domain immunoglobulin in healthy subjects and patients with osteoarthritis

2015 ◽  
Vol 23 ◽  
pp. A398-A399
Author(s):  
S.X. Wang ◽  
W. Liu ◽  
P. Jiang ◽  
M. Okun ◽  
R.A. Preston ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Phase 1 ◽  
Interleukin 1 ◽  
Variable Domain ◽  
Dual Variable

Pharmacokinetics and Tolerability of a Dual Variable Domain Immunoglobulin ABT-981 Against IL-1α and IL-1β in Healthy Subjects and Patients With Osteoarthritis of the Knee

2016 ◽  
Vol 56 (12) ◽  
pp. 1582-1590 ◽  
Author(s):  
Matthew P. Kosloski ◽  
Sandra Goss ◽  
Susanne X. Wang ◽  
Jia Liu ◽  
Ralf Loebbert ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Variable Domain ◽  
Osteoarthritis Of The Knee ◽  
Dual Variable

Pharmacokinetics of ABT-122, a TNF-α- and IL-17A-Targeted Dual-Variable Domain Immunoglobulin, in Healthy Subjects and Patients with Rheumatoid Arthritis: Results from Three Phase I Trials

2017 ◽  
Vol 57 (5) ◽  
pp. 613-623 ◽  
Author(s):  
Amit Khatri ◽  
Sandra Goss ◽  
Ping Jiang ◽  
Heikki Mansikka ◽  
Ahmed A. Othman
Keyword(s):  
Rheumatoid Arthritis ◽  
Phase I ◽  
Healthy Subjects ◽  
Variable Domain ◽  
Phase I Trials ◽  
Dual Variable ◽  
Three Phase ◽  
Tnf Α

scholarly journals Interleukin-1 dual variable domain immunoglobulin, a new potential treatment for osteoarthritis

2014 ◽  
Vol 22 ◽  
pp. S462-S463 ◽  
Author(s):  
S.X. Wang ◽  
F. Berenbaum ◽  
W.P. Maksymowych ◽  
W. Liu ◽  
M. Karunaratne ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Immunoglobulin A ◽  
Variable Domain ◽  
Potential Treatment ◽  
Dual Variable

SAT0448 Interleukin-1 Dual Variable–Domain Immunoglobulin Reduces Multiple Imflammatory Markers in Knee Osteoarthritis Patients

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 756.1-756 ◽  
Author(s):  
S.X. Wang ◽  
J.K. Medema ◽  
M.P. Kosloski ◽  
W. Liu ◽  
M.J. Saltarelli ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Interleukin 1 ◽  
Variable Domain ◽  
Dual Variable

THU0491 Dual Variable Domain-Immunoglobulin (DVD-IG™) ABT-981 Simultaneously and Dose-Dependently Inhibits Interleukin-1 Alpha and -1 Beta in Subjects with Knee Osteoarthritis

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 377.2-378
Author(s):  
S.X. Wang ◽  
R. Loebbert ◽  
E.R. Sampson ◽  
M.J. Saltarelli ◽  
J.K. Medema ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Interleukin 1 ◽  
Variable Domain ◽  
Dual Variable

Phase 1, open-label, dose-escalation and expansion study of ABT-165, a dual variable domain immunoglobulin (DVD-Ig) targeting both DLL4 and VEGF, in patients (pts) with advanced solid tumors.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 2507-2507 ◽  
Author(s):  
Michael S. Gordon ◽  
John J. Nemunaitis ◽  
Ramesh K. Ramanathan ◽  
George W. Sledge ◽  
Lan Wang ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Dose Escalation ◽  
Phase 1 ◽  
Variable Domain ◽  
Advanced Solid Tumors ◽  
Dual Variable ◽  
Open Label ◽  
Label Dose

scholarly journals Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study

2017 ◽  
Vol 25 (12) ◽  
pp. 1952-1961 ◽  
Author(s):  
S.X. Wang ◽  
S.B. Abramson ◽  
M. Attur ◽  
M.A. Karsdal ◽  
R.A. Preston ◽  
...  
Keyword(s):  
Phase 1 ◽  
Variable Domain ◽  
Osteoarthritis Of The Knee ◽  
Dual Variable ◽  
Phase 1 Study ◽  
Interleukin 1Α
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