The role of Letrozole (LE) in controlled ovarian stimulation (COS) in patients at high risk to develop ovarian hyper stimulation syndrome (OHSS). A prospective randomized controlled pilot study

AbstractThe role of adjuvant radiotherapy and/or chemotherapy in the primary treatment of endometrial cancer with a high risk of recurrence has still not been conclusively determined. The results of 3 large randomized controlled studies on different aspects of this issue have been published in full in recent months, and the relevant results are analyzed here.

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OC09.04: Ultrasound for monitoring controlled ovarian stimulation: a systematic review and meta-analysis of randomized controlled trials

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.12629 ◽

2013 ◽

Vol 42 (s1) ◽

pp. 18-18

Author(s):

W.P. Martins ◽

C.V. Vieira ◽

D.M. Teixeira ◽

M.A. Barbosa ◽

L.A. Dassunção ◽

...

Keyword(s):

Systematic Review ◽

Randomized Controlled Trials ◽

Ovarian Stimulation ◽

Meta Analysis ◽

Controlled Ovarian Stimulation ◽

Controlled Trials ◽

Randomized Controlled

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A Randomized Controlled Study to assess the Role of Routine Third Trimester Ultrasound in Low-risk Pregnancy on Antenatal Interventions and Perinatal Outcome

Journal of SAFOG with DVD ◽

10.5005/jp-journals-10006-1292 ◽

2014 ◽

Vol 6 (3) ◽

pp. 139-143 ◽

Cited By ~ 1

Author(s):

Hema Dhumale ◽

Yeshita Pujar ◽

Komal Gurunath Revankar

Keyword(s):

High Risk ◽

Perinatal Outcome ◽

Low Risk ◽

Controlled Study ◽

Third Trimester ◽

Randomized Controlled ◽

Risk Pregnancy ◽

Low Risk Pregnancy ◽

And Control

ABSTRACT Objective To assess the role of routine third trimester ultrasound in low-risk pregnancy on antenatal interventions and perinatal outcome. Design Randomized controlled study. Setting KLES Dr Prabhakar Kore Hospital and Medical Research Center, Belgaum. Subjects A total of 290 low-risk pregnant women between 34 and 37 weeks attending antenatal clinic and fulfilling inclusion criteria were allotted using computer-generated randomization numbers into study and control groups. Intervention In study group, third trimester ultrasound was performed to assess fetal growth, amniotic fluid index (AFI), malpresentations, and late onset fetal anomalies. In control group, no routine ultrasound was performed, unless indicated by clinical suspicion during subsequent visits. High-risk fetuses identified were managed as per the standard protocol. All women were followed to assess antenatal interventions, intrapartum events and perinatal outcome. Results Detection of high-risk fetuses antenatally in study and control groups was 17.25 and 2.07% respectively. This difference was statistically significant (p = —0.0001). Rates of antenatal interventions among study and control were 24.8 and 4.44% respectively. Prevalence of small for gestational age (SGA) fetuses among study and control was 6.9 vs 11.03% respectively. This difference was not statistically significant (p = —0.253). There was no statistical difference in adverse intrapartum events, cesarean section rate for nonreassuring cardiotocography (CTG), low Apgar score and neonatal intensive care unit (NICU) admissions among study and controls. Conclusion Routine third trimester ultrasound is a logical solution for detection of high-risk fetuses in low-risk pregnancies which would otherwise be missed by clinical examination. However, this leads to an increase in antenatal interventions without significantly influencing the perinatal outcome. How to cite this article Revankar KG, Dhumale H, Pujar Y. A Randomized Controlled Study to assess the Role of Routine Third Trimester Ultrasound in Low-risk Pregnancy on Antenatal Interventions and Perinatal Outcome. J South Asian Feder Obst Gynae 2014;6(3):139-143.

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Role of Somatostatin in the Prevention of Pancreatic Stump-related Morbidity following Elective Pancreaticoduodenectomy in High-risk Patients and Elimination of Surgeon-related Factors: Prospective, Randomized, Controlled Trial

World Journal of Surgery ◽

10.1007/s00268-003-6693-5 ◽

2003 ◽

Vol 27 (6) ◽

pp. 709-714 ◽

Cited By ~ 52

Author(s):

Yan-Shen Shan ◽

Edgar D. Sy ◽

Pin-Wen Lin

Keyword(s):

Randomized Controlled Trial ◽

High Risk ◽

Controlled Trial ◽

Related Factors ◽

Pancreatic Stump ◽

High Risk Patients ◽

Randomized Controlled ◽

Prospective Randomized Controlled Trial ◽

Risk Patients

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Confronting the potential role of Yoga in the molecular profile of rural high-risk women for Diabetes: a pilot study

Integrative Medicine Case Reports ◽

10.38205/imcr.020238 ◽

2021 ◽

Vol 2 (2) ◽

pp. 38

Author(s):

Navneet Kaur ◽

Shweta Ahuja ◽

Kanupriya Sharma ◽

Rakesh Malik ◽

Kavita Bakshi ◽

...

Keyword(s):

Pilot Study ◽

High Risk ◽

Rural Women ◽

Potential Role ◽

Cellular Growth ◽

Molecular Profile ◽

High Risk Women ◽

Beneficial Impact ◽

The Mind

Background and purpose: Yoga has been shown to have established beneficial impact through many previous studies. The mind-body practices like Yoga have an ameliorating effect on diabetes and prediabetes. The majority of prior published literature focused their attention on the glucose parameters in diabetic and prediabetic pathology. The purpose of the present pilot study is to explore the effect of AYUSH-approved Diabetic Yoga Protocol (DYP) on selected angiogenesis and neurogenesis markers in high-risk rural women for Diabetes. Methods: Total 15 high-risk women for Diabetes were selected from rural area of Chandigarh, for a 3-month DYP intervention. The pre-post single group experimental research design was implemented in the study. The changes in angiogenesis, neurogenesis parameters, and leptin were assessed at baseline and after 3 months after DYP intervention. Results: The result of the present study revealed that after 3 months of DYP intervention the statistically significant improvements were noticed on serum VEGF levels (p = 0.039). The improvements in angiogenin and BDNF levels were also seen after DYP practice. Conclusion: The results highlight the potential role of DYP on cellular growth and neuronal survival. Keywords: Diabetic Yoga Protocol, Indian Diabetes Risk Score, Prediabetes, angiogenesis, neurogenesis.

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A phase I pilot study of preoperative radiotherapy for prostate cancer: Long-term toxicity and oncologic outcomes.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.7_suppl.60 ◽

2019 ◽

Vol 37 (7_suppl) ◽

pp. 60-60

Author(s):

Noelia Sanmamed ◽

Rachel Glicksman ◽

John Thoms ◽

Alexandre Zlotta ◽

Antonio Finelli ◽

...

Keyword(s):

Prostate Cancer ◽

Pilot Study ◽

High Risk ◽

Phase I ◽

Oncologic Outcomes ◽

Gu Toxicity ◽

Long Term Follow Up

60 Background: Pre-operative radiotherapy (PreORT) improves local control in various cancer types, and has become an established oncologic treatment strategy. During 2001-2004, we conducted a phase I pilot study assessing the role of short-course PreORT for men with unfavourable intermediate- and high-risk localized prostate cancer (PCa). We present long-term follow-up toxicity and oncologic outcomes. Methods: Eligible patients had histologically proven PCa, cT1-T2N0M0, PSA > 15-35 ng/ml with any Gleason score, or PSA 10-15 ng/ml with Gleason score ≥7. Patients received 25 Gy in five consecutive daily fractions to the prostate, followed by radical prostatectomy (RadP) within 14 days after RT completion. Primary outcomes were intra-operative morbidity, and late genitourinary (GU) and gastrointestinal (GI) toxicities. Acute toxicity was assessed during radiotherapy treatment on daily basis using RTOG grade scoring scale. Patients were assessed post-RadP clinically and with PSA at 1 and 6 months, and every 6 months. Intra- and Post-RadP toxicity was documented prospectively and scored as per Common Terminology Criteria for Adverse Events v4.0. Biochemical failure (BF) was determined based on two consecutive post-RadP PSA > 0.2 ng/ml. Results: Fifteen patients were enrolled; 14 patients completed PreORT followed by RadP, which also included bilateral lymph node dissections in 13 cases. Median follow-up was 12.2 years (range 6.7-16.3 years). Late GU toxicity was common, with 2 patients (14.3%) experiencing G2 toxicity, and 6 patients (42.8%) G3 toxicity. There were no G4-5 late GU toxicity. Late GI toxicity was infrequent, with only 1 patient (7.1%) experiencing transient G2 proctitis. At last follow-up, 8 (57.1%) and 6 (42.8%) patients experienced BF and metastatic disease recurrence, respectively. Conclusions: The use of PreORT in men with high-risk PCa is associated with unexpected high-rates of late GU toxicity. Future studies examining the role of RT pre-RadP must cautiously select RT technique and dose schedule. Importantly, long-term follow-up data is essential to fully determine the therapeutic index of PreORT in the management of localized PCa. Clinical trial information: NCT00252447.

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