Age and Expression of CD163 and Colony-Stimulating Factor 1 Receptor (CD115) Are Associated With the Biological Behavior of Central Giant Cell Granuloma

Central giant cell granuloma (CGCG) is a benign non odontogenic lesion of jaw that may show aggressive behavior. It is classified as aggressive and non-aggressive lesion on the basis of biological behavior and radiographic features. Central giant cell lesion is more frequent in children and young adult before the age of 30 years with female predilection, with characteristic radiological and histopathological features. Here we present a case of a 35 years old female with clinical and radiological diagnosis of central giant cell lesion in posterior mandible confirmed by histopathology. A surgical approach with regular follow up is the treatment of choice in most of the cases. Key Words: Calcitonin, Corticosteroid, Curettage, Enucleation, Giant cell lesion

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Collision Lesion of Mandible—Coexistence of Keratocystic Odontogenic Tumor with Central Giant Cell Granuloma: A Rare Case Report

The Journal of Contemporary Dental Practice ◽

10.5005/jp-journals-10024-1327 ◽

2013 ◽

Vol 14 (2) ◽

pp. 355-359 ◽

Cited By ~ 1

Author(s):

C Prashanthi ◽

Vinayak Karun ◽

Mahesh Melkundi ◽

Sanjay Nyamati ◽

Annapoorna HB

Keyword(s):

Case Report ◽

Giant Cell ◽

Rare Case ◽

Giant Cells ◽

Odontogenic Tumor ◽

Biological Behavior ◽

Keratocystic Odontogenic Tumor ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Rare Case Report

ABSTRACT Aim and background An odontogenic keratocyst (OKC) or keratocystic odontogenic tumor (KCOT) and giant cell granuloma (GCG) in the jaws are common lesions which have been studied extensively in detail over the years. However, a lesion showing features of both is exceptionally rare and is reported only twice in the literature till date. Case description A rare case of OKC in mandible showing foci of GCG like areas is reported in a 29 years old male patient. Conclusion It seems to be a collision lesion, though the possibility of KCOT showing a reactive response to form giant cells or it being a rare variant cannot be totally ruled out. Clinical significance This entity requires aggressive treatment since biological behavior of this unique lesion is difficult to predict unless more of such lesions are reported and followed up in future. How to cite this article Ravi SB, Prashanthi C, Karun V, Melkundi M, Nyamati S, Annapoorna HB. Collision Lesion of Mandible: Coexistence of Keratocystic Odontogenic Tumor with Central Giant Cell Granuloma: A Rare Case Report. J Contemp Dent Pract 2013;14(2):355-359.

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Central giant cell granuloma in the mandibula: clinical, radiological and histopathological study in 2 clinical cases

Bulletin of the Academy of Sciences of Moldova. Medical Sciences ◽

10.52692/1857-0011.2021.2-70.18 ◽

2021 ◽

Vol 70 (2) ◽

Author(s):

Gheorghe Tibirna ◽

◽

Silvia Railean ◽

Egor Porosencov ◽

Tatiana Porosencova ◽

...

Keyword(s):

General Population ◽

Giant Cell ◽

Biological Behavior ◽

Unknown Etiology ◽

Histopathological Study ◽

Giant Cell Granuloma ◽

Local Inflammation ◽

Central Giant Cell Granuloma ◽

Neoplastic Lesion ◽

Proliferative Lesion

Central giant cell granuloma (CGCG) is a benign and proliferative lesion of the jaw, with an unknown etiology. It is widely considered to be a neoplastic lesion. The current etiology of GCGC is still unclear, although local inflammation, bleeding, and trauma have been suggested. The biological behavior of CGCG of the jaw varies from resting to aggressive with destructive expansion. The incidence in the general population is very low, and patients are generally under 30 years of age females. In this study, we report two cases of GCGC in 8-year-old and 13 year old girls treated surgically.

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