Cord Blood Zinc Protoporphyrin/Heme Ratio in Minority Neonates at Risk for Iron Deficiency

2008 ◽  
Vol 153 (1) ◽  
pp. 133-136 ◽  
Author(s):  
Nicole L. Baumann-Blackmore ◽  
Elizabeth Goetz ◽  
Sharon E. Blohowiak ◽  
Olamide Zaka ◽  
Pamela J. Kling
Keyword(s):  
At Risk ◽  
Iron Deficiency ◽  
Cord Blood ◽  
Zinc Protoporphyrin ◽  
Blood Zinc

scholarly journals Cord Blood-Derived Exosomal CNTN2 and BDNF: Potential Molecular Markers for Brain Health of Neonates at Risk for Iron Deficiency

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2478 ◽  
Author(s):  
Paulina S. Marell ◽  
Sharon E. Blohowiak ◽  
Michael D. Evans ◽  
Michael K. Georgieff ◽  
Pamela J. Kling ◽  
...  
Keyword(s):  
At Risk ◽  
Molecular Markers ◽  
Iron Deficiency ◽  
Cord Blood ◽  
Negative Correlation ◽  
Iron Status ◽  
Deficiency Anemia ◽  
Neonatal Brain ◽  
Maternal Risk ◽  
Obesity And Diabetes

Maternal iron deficiency anemia, obesity, and diabetes are prevalent during pregnancy. All are associated with neonatal brain iron deficiency (ID) and neurodevelopmental impairment. Exosomes are extracellular vesicles involved in cell–cell communication. Contactin-2 (CNTN2), a neural-specific glycoprotein, and brain-derived neurotrophic factor (BDNF) are important in neurodevelopment and found in exosomes. We hypothesized that exosomal CNTN2 and BDNF identify infants at risk for brain ID. Umbilical cord blood samples were measured for iron status. Maternal anemia, diabetes, and body mass index (BMI) were recorded. Cord blood exosomes were isolated and validated for the exosomal marker CD81 and the neural-specific exosomal marker CNTN2. Exosomal CNTN2 and BDNF levels were quantified by ELISA. Analysis of CNTN2 and BDNF levels as predictors of cord blood iron indices showed a direct correlation between CNTN2 and ferritin in all neonates (n = 79, β = 1.75, p = 0.02). In contrast, BDNF levels inversely correlated with ferritin (β = −1.20, p = 0.03), with stronger association in female neonates (n = 37, β = −1.35, p = 0.06), although there is no evidence of a sex-specific effect. Analysis of maternal risk factors for neonatal brain ID as predictors of exosomal CNTN2 and BDNF levels showed sex-specific relationships between infants of diabetic mothers (IDMs) and CNTN2 levels (Interaction p = 0.0005). While male IDMs exhibited a negative correlation (n = 42, β = −0.69, p = 0.02), female IDMs showed a positive correlation (n = 37, β = 0.92, p = 0.01) with CNTN2. A negative correlation between BNDF and maternal BMI was found with stronger association in female neonates (per 10 units BMI, β = −0.60, p = 0.04). These findings suggest CNTN2 and BNDF are respective molecular markers for male and female neonates at risk for brain ID. This study supports the potential of exosomal markers to assess neonatal brain status in at-risk infants.

scholarly journals Effect of Maternal Nutritional Status and Mode of Delivery on Zinc and Iron Stores at Birth

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 860
Author(s):  
Oraporn Dumrongwongsiri ◽  
Pattanee Winichagoon ◽  
Nalinee Chongviriyaphan ◽  
Umaporn Suthutvoravut ◽  
Veit Grote ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Cord Blood ◽  
Mode Of Delivery ◽  
Serum Zinc ◽  
Maternal Blood ◽  
Second Trimester ◽  
Food Frequency ◽  
Iron Stores ◽  
Maternal Nutritional Status ◽  
Blood Zinc

Zinc and iron deficiencies among infants aged under 6 months may be related with nutrient store at birth. This study aimed to investigate the association between zinc and iron stores at birth with maternal nutritional status and intakes during pregnancy. 117 pregnant women were enrolled at the end of second trimester and followed until delivery. Clinical data during pregnancy, including pre-pregnancy body mass index (BMI) and at parturition were collected from medical record. Zinc and iron intakes were estimated from a food frequency questionnaire. Serum zinc and ferritin were determined in maternal blood at enrollment and cord blood. Mean cord blood zinc and ferritin were 10.8 ± 2.6 µmol/L and 176 ± 75.6 µg/L, respectively. Cord blood zinc was associated with pre-pregnancy BMI (adj. ß 0.150; p = 0.023) and serum zinc (adj. ß 0.115; p = 0.023). Cord blood ferritin was associated with pre-pregnancy BMI (adj. ß −5.231; p = 0.009). Cord blood zinc and ferritin were significantly higher among those having vaginal delivery compared to cesarean delivery (adj. ß 1.376; p = 0.007 and 32.959; p = 0.028, respectively). Maternal nutritional status and mode of delivery were significantly associated with zinc and iron stores at birth. Nutrition during preconception and pregnancy should be ensured to build adequate stores of nutrients for infants.

scholarly journals Prenatal Iron Deficiency and Replete Iron Status Are Associated with Adverse Birth Outcomes, but Associations Differ in Ghana and Malawi

2019 ◽  
Vol 149 (3) ◽  
pp. 513-521 ◽  
Author(s):  
Brietta M Oaks ◽  
Josh M Jorgensen ◽  
Lacey M Baldiviez ◽  
Seth Adu-Afarwuah ◽  
Ken Maleta ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Birth Outcomes ◽  
Regression Models ◽  
Iron Status ◽  
Secondary Data ◽  
Hemoglobin Concentration ◽  
Late Pregnancy ◽  
Zinc Protoporphyrin ◽  
Adverse Birth Outcomes ◽  
Soluble Transferrin Receptor

ABSTRACTBackgroundPrevious literature suggests a U-shaped relation between hemoglobin concentration and adverse birth outcomes. There is less evidence on associations between iron status and birth outcomes.ObjectiveOur objective was to determine the associations of maternal hemoglobin concentration and iron status with birth outcomes.MethodsWe conducted a secondary data analysis of data from 2 cohorts of pregnant women receiving iron-containing nutritional supplements (20–60 mg ferrous sulfate) in Ghana (n = 1137) and Malawi (n = 1243). Hemoglobin concentration and 2 markers of iron status [zinc protoporphyrin and soluble transferrin receptor (sTfR)] were measured at ≤20 weeks and 36 weeks of gestation. We used linear and Poisson regression models and birth outcomes included preterm birth (PTB), newborn stunting, low birth weight (LBW), and small-for-gestational-age.ResultsPrevalence of iron deficiency (sTfR >6.0 mg/L) at enrollment was 9% in Ghana and 20% in Malawi. In early pregnancy, iron deficiency was associated with PTB (9% compared with 17%, adjusted RR: 1.63; 95% CI: 1.14, 2.33) and stunting (15% compared with 23%, adjusted RR: 1.44; 95% CI: 1.09, 1.94) in Malawi but not Ghana, and was not associated with LBW in either country; replete iron status (sTfR <10th percentile) was associated with stunting (9% compared with 15%, adjusted RR: 1.71; 95% CI: 1.06, 2.77) in Ghana, but not PTB or LBW, and was not associated with any birth outcomes in Malawi. In late pregnancy, iron deficiency was not related to birth outcomes in either country and iron-replete status was associated with higher risk of LBW (8% compared with 16%, adjusted RR: 1.90; 95% CI: 1.17, 3.09) and stunting (6% compared with 13%, adjusted RR: 2.14; 95% CI: 1.21, 3.77) in Ghana, but was not associated with birth outcomes in Malawi.ConclusionsThe associations of low or replete iron status with birth outcomes are population specific. Research to replicate and extend these findings would be beneficial. These trials were registered at clinicaltrials.gov as NCT00970866 (Ghana) and NCT01239693 (Malawi).

Detection of iron-deficiency anemia in hospitalized patients by zinc protoporphyrin

1996 ◽  
Vol 244 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Shan S. WongA ◽  
Ala S. Qutishat ◽  
Jason Lange ◽  
Terrie G. Gornet ◽  
L. Maximilian Buja
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Hospitalized Patients ◽  
Deficiency Anemia ◽  
Zinc Protoporphyrin

Are Young Women with Low Iron Stores at Risk of Zinc as Well as Iron Deficiency?

2002 ◽  
pp. 323-328 ◽  
Author(s):  
R. S. Gibson ◽  
A. -L. Heath ◽  
N. Prosser ◽  
W. Parnell ◽  
U. M. Donovan ◽  
...  
Keyword(s):  
At Risk ◽  
Iron Deficiency ◽  
Young Women ◽  
Iron Stores

scholarly journals Zinc Protoporphyrin/Heme Ratios (ZnPP/H) as a Potential Newborn Screen for Iron Deficiency.

2010 ◽  
Vol 83 (Suppl_1) ◽  
pp. 585-585
Author(s):  
Steven Marmer ◽  
Melinda Chen ◽  
Beth Fischer ◽  
Vidya Sridhar ◽  
Sharon Blohowiak ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Zinc Protoporphyrin ◽  
Newborn Screen

scholarly journals Cord Blood Albumin as a Predictor of Significant Hyperbilirubinemia in Term and Preterm Neonates

2020 ◽  
Vol 8 (1) ◽  
pp. 01-04
Author(s):  
Anurag Singh Chandel ◽  
Ravindra Chittal
Keyword(s):  
At Risk ◽  
Cord Blood ◽  
Surrogate Marker ◽  
Albumin Level ◽  
Serum Bilirubin Level ◽  
Full Term ◽  
Medical Attention ◽  
Preterm Neonates ◽  
Blood Albumin

Background: Jaundice is the most common condition requiring medical attention and readmission. As neonates are discharged within 48 hours of birth, close follow up is very important to look for jaundice. In developing countries, follow up visits are difficult. Therefore, it is important to identify at risk neonates before discharge. This study helps in identifying neonates at risk for hyperbilirubinemia. This study includes both healthy pre-term and full term neonates.Aim & Objective:To find correlation between cord blood albumin level with serum bilirubin level in healthy term and preterm neonates and correlation between maternal serum albumin level with cord blood albumin.Subject and Method:This study included 106 neonates (full-term and pre-term) born in Lilavati Hospital, Mumbai during period of March to December 2017. Result:Out of 106 neonates, 42(39.6%) developed significant hyperbilirubinemia. 17 (58.6%) neonates with cord blood albumin below 2.8 g/dl required phototherapy against 24 (50%) with cord blood albumin between 2.8-3.3 g/dl. In this study, 11 (73.3%) out of 15 pre-term and 6 (42.9%) of 14 full-term neonates with cord blood albumin below 2.8 g/dl developed significant hyperbilirubinemia and required phototherapy. A significant association wasobserved between maternal and cord blood albumin level. Conclusion:Significant association observed between cord blood albuminand tendencies of significant hyperbilirubinemia. So, cord blood albumin can be used as a surrogate marker for screening newborns for development of significant hyperbilirubinemia

Standardized Evaluation of Cord Gases in Neonates at Risk for Hypoxic Ischemic Encephalopathy

2021 ◽  
Author(s):  
Elizabeth Blecharczyk ◽  
Lucy Lee ◽  
Krista Birnie ◽  
Arun Gupta ◽  
Alexis Davis ◽  
...  
Keyword(s):  
At Risk ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Care Pathway ◽  
Clinical Care ◽  
Blood Gases ◽  
Hypoxic Ischemic Encephalopathy ◽  
Blood Gas ◽  
Clinical Care Pathway ◽  
Ischemic Encephalopathy

BACKGROUND: Umbilical-cord acidemia may indicate perinatal asphyxia and places a neonate at increased risk for hypoxic ischemic encephalopathy (HIE). Our specific aim was to develop a standardized clinical care pathway, ensuring timely identification and evaluation of neonates with umbilical-cord acidemia at risk for HIE. METHODS: A standardized clinical care pathway to screen inborn neonates ≥36 weeks with abnormal cord blood gases (a pH of ≤7.0 or base deficit of ≥10) for HIE was implemented in January 2016. Abnormal cord blood gases resulted in a direct notification from the laboratory to an on-call physician. Evaluation included a modified Sarnat examination, postnatal blood gas, and standardized documentation. The percentage of neonates in which physician notification, documented Sarnat examination, and postnatal blood gas occurred was examined for 6 months before and 35 months after implementation. RESULTS: Of 203 neonates with abnormal cord gases in the post–quality improvement (QI) period, physician notification occurred in 92%. In the post-QI period, 94% had a documented Sarnat examination, and 94% had postnatal blood gas, compared with 16% and 11%, respectively, of 87 neonates in the pre-QI period. In the post-QI period, of those evaluated, &gt;96% were documented within 4 hours of birth. In the post-QI period, 15 (7.4%) neonates were cooled; 13 were in the NICU at time of identification, but 2 were identified in the newborn nursery and redirected to the NICU for cooling. CONCLUSIONS: A standardized screening pathway in neonates with umbilical-cord acidemia led to timely identification and evaluation of neonates at risk for HIE.

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