scholarly journals Design, synthesis, and evaluation of fluoroquinolone derivatives as MicroRNA-21 small-molecule inhibitors

2022 ◽  
Author(s):  
Yuan-Yuan Hei ◽  
Si Wang ◽  
Xiao-Xiao Xi ◽  
Hai-Peng Wang ◽  
Yuanxu Guo ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Design Synthesis ◽  
Fluoroquinolone Derivatives

scholarly journals Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1

2012 ◽  
Vol 20 (1) ◽  
pp. 487-497 ◽  
Author(s):  
Joseph J. Jablonski ◽  
Dipwanita Basu ◽  
Daniel A. Engel ◽  
H. Mario Geysen
Keyword(s):  
Influenza Virus ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Virus Protein ◽  
Design Synthesis

scholarly journals Design, Synthesis and Biological Evaluation of Oxindole-Based Chalcones as Small-Molecule Inhibitors of Melanogenic Tyrosinase

2017 ◽  
Vol 65 (9) ◽  
pp. 833-839 ◽  
Author(s):  
Sharad Kumar Suthar ◽  
Sumit Bansal ◽  
Niteen Narkhede ◽  
Manju Guleria ◽  
Angel Treasa Alex ◽  
...  
Keyword(s):  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

2011 ◽  
Vol 19 (1) ◽  
pp. 91-101 ◽  
Author(s):  
Judith M. LaLonde ◽  
Mark A. Elban ◽  
Joel R. Courter ◽  
Akihiro Sugawara ◽  
Takahiro Soeta ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Gp120 Binding ◽  
Synthesis And Biological Evaluation

Development and Challenges of HER2 Inhibitors Discovery

2020 ◽  
Vol 20 ◽  
Author(s):  
Zhi-Gang Sun ◽  
Liang-Hui Zhao ◽  
Zhi-Na Li ◽  
Hai-Liang Zhu
Keyword(s):  
Clinical Research ◽  
Small Molecule ◽  
Small Molecule Inhibitors ◽  
Cancer Drugs ◽  
Design Synthesis ◽  
Inhibitor Development ◽  
Her Family ◽  
The World ◽  
The Future

: The treatment of cancer has always been a major problem in the world. Some cancers cannot be treated with surgery, but only with cancer drugs. Among many cancer drugs, small molecule inhibitors play an irreplaceable role. HER2 is one of the HER family, and the development of HER2 inhibitors has made a huge contribution to the treatment of cancer. Some HER2 inhibitors are already on the market, and some HER2 inhibitors are undergoing clinical research. The design, synthesis and development of new HER2 inhibitors targeting different targets are also ongoing, and some are even applying for clinical research. The HER2 inhibitors that are on the market have developed resistance, which brings great challenges to the HER2 inhibitor development in the future. This article reviews the development and challenges of HER2 inhibitors discovery.

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