Substitutional impact on biological activity of new water soluble Ni(II) complexes: Preparation, spectral characterization, X-ray crystallography, DNA/protein binding, antibacterial activity and in vitro cytotoxicity

The compound, diethyl 1-((4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl)-1H-1,2,3-triazole-4,5-dicarboxylate 2, was synthesized in high yield, through 1,3-dipolar cycloaddition reaction of 4-(azidomethyl)-4-methyl-2-phenyl-4,5-dihydrooxazole and diethyl but-2-ynedioate in the absence of a solvent. The structure of the synthesized compound was established on the basis of NMR spectroscopy (1H, 13C), X-ray crystallography, and MS data. The prepared compound was also tested in vitro for its antibacterial activity against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli). The calculation of MBC/MIC ratio showed that this triazole derivative 2 had a bactericidal effect on the two strains tested.

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A pseudo trinuclear nickel–sodium complex containing tris(8‐methyl‐2‐oxo‐quinolidineamino ethylamine): Synthesis, spectral characterization, X‐ray crystallography and in vitro biological evaluations

Applied Organometallic Chemistry ◽

10.1002/aoc.5605 ◽

2020 ◽

Vol 34 (5) ◽

Cited By ~ 1

Author(s):

P. Naveen ◽

B. Vijaya Pandiyan ◽

D. Anu ◽

F. Dallemer ◽

P. Kolandaivel ◽

...

Keyword(s):

Spectral Characterization ◽

Sodium Complex ◽

X Ray ◽

X Ray Crystallography

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Synthesis, Characterization, and in Vitro Cytotoxicity of Some Gold(I) and Trans Platinum(II) Thionate Complexes Containing Water-Soluble PTA and DAPTA Ligands. X-ray Crystal Structures of [Au(SC4H3N2)(PTA)],trans-[Pt(SC4H3N2)2(PTA)2],trans-[Pt(SC5H4N)2(PTA)2], andtrans-[Pt(SC5H4N)2(DAPTA)2]

Inorganic Chemistry ◽

10.1021/ic7021903 ◽

2008 ◽

Vol 47 (13) ◽

pp. 5641-5648 ◽

Cited By ~ 72

Author(s):

Susana Miranda ◽

Elena Vergara ◽

Fabian Mohr ◽

Dick de Vos ◽

Elena Cerrada ◽

...

Keyword(s):

Crystal Structures ◽

In Vitro Cytotoxicity ◽

Water Soluble ◽

X Ray

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Synthesis of a new pyridinyl thiazole ligand with hydrazone moiety and its cobalt(III) complex: X-ray crystallography, in vitro evaluation of antibacterial activity

Polyhedron ◽

10.1016/j.poly.2017.06.024 ◽

2017 ◽

Vol 134 ◽

pp. 230-237 ◽

Cited By ~ 15

Author(s):

Pradip Bera ◽

Paula Brandão ◽

Gopinath Mondal ◽

Harekrishna Jana ◽

Abhimanyu Jana ◽

...

Keyword(s):

Antibacterial Activity ◽

In Vitro Evaluation ◽

X Ray ◽

X Ray Crystallography

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o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity

Molecules ◽

10.3390/molecules23092194 ◽

2018 ◽

Vol 23 (9) ◽

pp. 2194 ◽

Cited By ~ 1

Author(s):

Guo Jin ◽

Hyun Ban ◽

Hiroyuki Nakamura ◽

Jong-Dae Lee

Keyword(s):

Biological Activity ◽

B16 Melanoma ◽

Molecular Structures ◽

In Vitro Studies ◽

Structural Studies ◽

Triazine Ring ◽

X Ray ◽

X Ray Crystallography ◽

Triazine Derivatives

Morpholine- and bis(2-methoxyethyl)amine-substituted 1,3,5-triazine derivatives containing an alkoxy-o-carborane in the 6-position of the triazine ring were successfully synthesized. The molecular structures of the methoxy- and ethoxy-o-carboranyl-1,3,5-triazines were established by X-ray crystallography. In vitro studies showed that the methylene bridged morpholine- and bis(2-methoxyethyl)amine-substituted o-carboranyl-1,3,5-triazines accumulated to high levels in B16 melanoma cells and exhibited higher cytotoxicity than p-boronophenylalanine.

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Synthesis of [C5H5NH][Ph2Sn(μ2-SCH2COO)CI] with Good Biological Activity In Vitro Anti-Tumor

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.726-731.222 ◽

2013 ◽

Vol 726-731 ◽

pp. 222-224 ◽

Cited By ~ 1

Author(s):

Gui Yun Zhong

Keyword(s):

Crystal Structure ◽

Biological Activity ◽

Mercaptoacetic Acid ◽

X Ray ◽

X Ray Crystallography ◽

Pyridinium Cation ◽

H Nmr ◽

Anti Tumor Activity ◽

Cl Atom

Five-coordinated anionic tin (IV) complexes [C5H5NH][Ph2Sn (μ2-SCH2COO)C was synthesized by the reaction of mercaptoacetic acid with diphenyltin dichloride in the present of pyridine. The structure was characterized by elemental analysis, IR, 1H NMR. The crystal structure of [C5H5N[Ph2Sn (μ2-SCH2COO)C was determined by X-ray crystallography. The structure consists of an anion part, and a pyridinium cation part as a counterion. The tin atom has a distorted cis-tbp geometry with two carbon and one sulfur atoms occupying the equatorial positions and the o atom and Cl atom occupying the axial positions. We tested the activity of the product in vitro antitumor for A-549, HCT-8 and Bel-7402, results showed that the compound has a strong anti-tumor activity for A-549, HCT-8, IC50 values were 0.91 and 0.34 μg ml-1, respectively.

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Synthesis, characterization and in vitro cytotoxicity study of Co and Ni ferrite nanoparticles prepared by sol-gel method

SN Applied Sciences ◽

10.1007/s42452-021-04709-y ◽

2021 ◽

Vol 3 (7) ◽

Author(s):

Alexandre Pancotti ◽

Dener Pereira Santos ◽

Dielly Oliveira Morais ◽

Mauro Vinícius de Barros Souza ◽

Débora R. Lima ◽

...

Keyword(s):

Photoelectron Spectroscopy ◽

Sol Gel ◽

Test Sample ◽

In Vitro Cytotoxicity ◽

Gel Method ◽

X Ray ◽

Sol Gel Method ◽

Transmission Electron ◽

Crystallite Sizes

AbstractIn this study, we report the synthesis and characterization of NiFe2O4 and CoFe2O4 nanoparticles (NPs) which are widely used in the biomedical area. There is still limited knowledge how the properties of these materials are influenced by different chemical routes. In this work, we investigated the effect of heat treatment over cytotoxicity of cobalt and niquel ferrites NPs synthesized by sol-gel method. Then the samples were studied using transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), Fourier Transform Infrared Spectroscopy Analysis (FTIR), and X-ray fluorescence (XRF). The average crystallite sizes of the particles were found to be in the range of 20–35 nm. The hemocompatibility (erythrocytes and leukocytes) was checked. Cytotoxicity results were similar to those of the control test sample, therefore suggesting hemocompatibility of the tested materials.

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Assessment of SnFe2O4 Nanoparticles for Potential Application in Theranostics: Synthesis, Characterization, In Vitro, and In Vivo Toxicity

Materials ◽

10.3390/ma14040825 ◽

2021 ◽

Vol 14 (4) ◽

pp. 825

Author(s):

Saman Sargazi ◽

Mohammad Reza Hajinezhad ◽

Abbas Rahdar ◽

Muhammad Nadeem Zafar ◽

Aneesa Awan ◽

...

Keyword(s):

Electron Microscopy ◽

A549 Cells ◽

In Vitro Cytotoxicity ◽

Hek293 Cells ◽

Hydrothermal Route ◽

X Ray ◽

Tin Chloride ◽

Bet Analysis

In this research, tin ferrite (SnFe2O4) NPs were synthesized via hydrothermal route using ferric chloride and tin chloride as precursors and were then characterized in terms of morphology and structure using Fourier-transform infrared spectroscopy (FTIR), Ultraviolet–visible spectroscopy (UV-Vis), X-ray power diffraction (XRD), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), and Brunauer–Emmett–Teller (BET) method. The obtained UV-Vis spectra was used to measure band gap energy of as-prepared SnFe2O4 NPs. XRD confirmed the spinel structure of NPs, while SEM and TEM analyses disclosed the size of NPs in the range of 15–50 nm and revealed the spherical shape of NPs. Moreover, energy dispersive X-ray spectroscopy (EDS) and BET analysis was carried out to estimate elemental composition and specific surface area, respectively. In vitro cytotoxicity of the synthesized NPs were studied on normal (HUVEC, HEK293) and cancerous (A549) human cell lines. HUVEC cells were resistant to SnFe2O4 NPs; while a significant decrease in the viability of HEK293 cells was observed when treated with higher concentrations of SnFe2O4 NPs. Furthermore, SnFe2O4 NPs induced dramatic cytotoxicity against A549 cells. For in vivo study, rats received SnFe2O4 NPs at dosages of 0, 0.1, 1, and 10 mg/kg. The 10 mg/kg dose increased serum blood urea nitrogen and creatinine compared to the controls (P < 0.05). The pathology showed necrosis in the liver, heart, and lungs, and the greatest damages were related to the kidneys. Overall, the in vivo and in vitro experiments showed that SnFe2O4 NPs at high doses had toxic effects on lung, liver and kidney cells without inducing toxicity to HUVECs. Further studies are warranted to fully elucidate the side effects of SnFe2O4 NPs for their application in theranostics.

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