New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic characterization, X-ray structure determination, in vitro anticancer activity on various human carcinoma cell lines and computational studies

2018 ◽  
Vol 178 ◽  
pp. 428-439 ◽  
Author(s):  
Ömer Şahin ◽  
Ümmühan Özmen Özdemir ◽  
Nurgül Seferoğlu ◽  
Zuhal Karagöz Genc ◽  
Kerem Kaya ◽  
...  
Keyword(s):  
Schiff Base ◽  
Structure Determination ◽  
Carcinoma Cell ◽  
Spectroscopic Characterization ◽  
Computational Studies ◽  
Human Carcinoma ◽  
X Ray ◽  
Carcinoma Cell Lines ◽  
Human Carcinoma Cell

Synthesis and Anti-Tumor Activity Evaluation of Novel 7-Fluoro-4-(1- Piperazinyl) Quinolines

2019 ◽  
Vol 16 (6) ◽  
pp. 663-669
Author(s):  
Dan Liu ◽  
Aiqi Xue ◽  
Zhixin Liu ◽  
Yi Zhang ◽  
Penghui Peng ◽  
...  
Keyword(s):  
Spectral Analysis ◽  
Cancer Therapy ◽  
Carcinoma Cell ◽  
A549 Cells ◽  
Quinoline Derivatives ◽  
Human Carcinoma ◽  
Carcinoma Cell Lines ◽  
Human Carcinoma Cell ◽  
Anti Tumor Activity

Background: Three series of new 7-fluoro-4-(1-piperazinyl) quinolines (I1~I6, II1~II2 and IV1~IV4) were synthesized. Their anti-tumor activity was evaluated in vitro against three human carcinoma cell lines, namely SGC-7901 cells, BEL-7402 cells and A549 cells expressing high levels of EGFR by Methyl Thiazolyl Terazolium (MTT) assay. Methods: Three series of quinoline derivatives were synthesized, characterized and evaluated for their in vitro anti-tumor activities. Results and Discussion: Structures of the newly synthesized compounds were confirmed by spectral analysis. The preliminary bioassay indicated that compounds I1, I10 and II1 exhibited better anti-tumor activity than the rest of the target compounds and gefitinib against A549 cell based assay, which demonstrated that compounds I1, I10 and II1 are potential agents for cancer therapy. Results suggested that the substitutes on piperazinyl influenced anti-tumor activities remarkably. Conclusion: These results are useful for discovering more potent novel anti-tumor compounds and further studies are ongoing.

Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfectedp16INK4

1996 ◽  
Vol 16 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Elisa A. Spillare ◽  
Aikou Okamoto ◽  
Koichi Hagiwara ◽  
Douglas J. Demetrick ◽  
Manuel Serrano ◽  
...  
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Human Carcinoma ◽  
Carcinoma Cell Lines ◽  
Human Carcinoma Cell

scholarly journals Cytotoxic heteroleptic heptacoordinate salan zirconium(iv)-bis-chelates – synthesis, aqueous stability and X-ray structure analysis

2016 ◽  
Vol 52 (66) ◽  
pp. 10151-10154 ◽  
Author(s):  
Fabian Schneider ◽  
Tiankun Zhao ◽  
Thomas Huhn
Keyword(s):  
Cell Lines ◽  
Structure Analysis ◽  
Carcinoma Cell ◽  
Human Carcinoma ◽  
X Ray ◽  
Carcinoma Cell Lines ◽  
Human Carcinoma Cell

A series of novel Zr(iv)salan complexes is reported. The initial metalation product[(L1)2Zr]is highly water sensitive whereas ligand exchanged[L1Zr(dipic)]hydrolyses rather slowly with a bis-hydroxo Zr(iv) species identified by MS as an intermediate.[L1Zr(dipic)]is cytotoxic in the range of cisplatin against two human carcinoma cell lines.

The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines

2009 ◽  
Vol 44 (6) ◽  
pp. 2736-2740 ◽  
Author(s):  
Sau Hing Chan ◽  
Kim Hung Lam ◽  
Chung Hin Chui ◽  
Roberto Gambari ◽  
Marcus Chun Wah Yuen ◽  
...  
Keyword(s):  
Cell Lines ◽  
Antiproliferative Activity ◽  
Carcinoma Cell ◽  
Human Carcinoma ◽  
Carcinoma Cell Lines ◽  
Human Carcinoma Cell

scholarly journals In vitro cytotoxicity of compounds isolated from Desbordesia glaucescens against human carcinoma cell lines

2017 ◽  
Vol 111 ◽  
pp. 37-43 ◽  
Author(s):  
V. Kuete ◽  
F.L. Dongmo Mafodong ◽  
I. Celik ◽  
S.A.T. Fobofou ◽  
B.L. Ndontsa ◽  
...  
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
In Vitro Cytotoxicity ◽  
Human Carcinoma ◽  
Carcinoma Cell Lines ◽  
Human Carcinoma Cell

In vitro schedule-dependent interaction between paclitaxel and cisplatin in human carcinoma cell lines

1996 ◽  
Vol 37 (6) ◽  
pp. 525-530 ◽  
Author(s):  
Y. Kano ◽  
Miyuki Akutsu ◽  
Saburo Tsunoda ◽  
Kenichi Suzuki ◽  
Yasuo Yazawa
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Human Carcinoma ◽  
Carcinoma Cell Lines ◽  
Human Carcinoma Cell ◽  
Dependent Interaction

scholarly journals IN VITRO ANTICANCER EFFECT OF ARTABOTRYS CRASSIFOLIUS HOOK.F. & THOMSON AGAINST HUMAN CARCINOMA CELL LINES

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Kok Kwan Tan ◽  
Tracey D Bradshaw ◽  
Jessica Chu ◽  
Teng Jin Khoo ◽  
Christophe Wiart
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Anticancer Effect ◽  
Human Carcinoma ◽  
Carcinoma Cell Lines ◽  
Human Carcinoma Cell

Schedule-Dependent Interactions Between Pemetrexed and Cisplatin in Human Carcinoma Cell Lines In Vitro

2006 ◽  
Vol 16 (2) ◽  
pp. 85-95 ◽  
Author(s):  
Yasuhiko Kano ◽  
Miyuki Akutsu ◽  
Saburo Tsunoda ◽  
Tohru Izumi ◽  
Hiroyuki Kobayashi ◽  
...  
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Human Carcinoma ◽  
Carcinoma Cell Lines ◽  
Human Carcinoma Cell

scholarly journals Glycoalkaloids as medicinal agents from callus and regenerated plants of Solanum nigrum var. judaicum

2019 ◽  
Vol 10 (3) ◽  
pp. 325-337
Author(s):  
Hanan Abd Al-Hay Al-Ashaal
Keyword(s):  
Cell Lines ◽  
Carcinoma Cell ◽  
Radical Scavenging ◽  
Solanum Nigrum ◽  
Therapeutic Effects ◽  
Human Carcinoma ◽  
Carcinoma Cell Lines ◽  
Human Carcinoma Cell ◽  
Anti Inflammatory

The target of this study is production of glycoalkaloids from cultures of Solanum nigrum var. judaicum Besser. Further, to evaluate their therapeutic effects. S. nigrum var. judaicum leaves were implanted in MS media containing growth regulators for in vitro study. HPLC analyses were applied for qualitative and quantitative determination of glycoalkaloids. Cytotoxic effects against human carcinoma cell lines were evaluated. In addition, antiviral, antioxidant, anti-inflammatory and antiparasitic activities of the formed glycoalkaloids were estimated.  HPLC data indicated the success of in vitro solasodine and solanidine glycosides production. Solasonine represented the highest concentration. Biological assays illustrated that obtained glycoalkaloids exhibited cytotoxic activity against human carcinoma cell lines that may be attributed to free radical scavenging activity (69.98%). Strong antiherps performance was observed (94%). In addition, the glycoalkaloids showed in vitro schistomicidal (IC50 76.4 ppm) and fasciolicidal (IC50 76.6 ppm) activities. In vivo anti-inflammatory assay revealed potent activity against carrageenan induced edema. Glycoalkaloids were formed 2-5 folds that of intact plant pointed to the efficiency of the cultures. The present findings referred to the pronounced biological performance of the produced glycoalkaloids including antiviral, cytotoxic anti-inflammatory and antiparasitic activities. Botanical derived medication from S. nigrum var. judaicum could be accomplished guided with the present data.  

Sign in / Sign up

Export Citation Format

Share Document