Thermostable potassium channel-inhibiting neurotoxins in processed scorpion medicinal material revealed by proteomic analysis: Implications of its pharmaceutical basis in traditional Chinese medicine

2019 ◽  
Vol 206 ◽  
pp. 103435 ◽  
Author(s):  
Fan Yang ◽  
Danya Wang ◽  
Yongjia Tong ◽  
Chenghu Qin ◽  
Liuting Yang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Potassium Channel ◽  
Proteomic Analysis ◽  
Medicinal Material

scholarly journals Poria cum Radix Pini Rescues Barium Chloride-Induced Arrhythmia by Regulating the cGMP-PKG Signalling Pathway Involving ADORA1 in Zebrafish

2021 ◽  
Vol 12 ◽  
Author(s):  
Ning-Juan Yang ◽  
Yan-Ru Liu ◽  
Zhi-Shu Tang ◽  
Jin-Ao Duan ◽  
Ya-Feng Yan ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Correlation Analysis ◽  
Barium Chloride ◽  
Signalling Pathway ◽  
Network Pharmacology ◽  
Myocardial Cells ◽  
Medicinal Material ◽  
Analysis Methods

The traditional Chinese medicine Poria cum Radix Pini (PRP) is a fungal medicinal material that has been proven to play an important role in the treatment of arrhythmia. However, the mechanism of its effect on arrhythmia is still unclear. In this study, network pharmacology and metabolomics correlation analysis methods were used to determine the key targets, metabolites and potential pathways involved in the effects of PRP on arrhythmia. The results showed that PRP can significantly improve cardiac congestion, shorten the SV-BA interval and reduce the apoptosis of myocardial cells induced by barium chloride in zebrafish. By upregulating the expression of the ADORA1 protein and the levels of adenosine and cGMP metabolites in the cGMP-PKG signalling pathway, PRP can participate in ameliorating arrhythmia. Therefore, we believe that PRP shows great potential for the treatment of arrhythmia.

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