ATUAÇÃO DO ENFERMEIRO DA ESTRATÉGIA DE SAÚDE DA FAMÍLIA NO TRATAMENTO ALTERNATIVO COM CANNABIS MEDICINAL NA DOENÇA DE ALZHEIMER.

Introdução: A Doença de Alzheimer (DA) é uma doença neurodegenerativa progressiva, a qual pode levar o paciente a um estado de dependência total e incapacitação devido à deterioração das funções cognitivas, em especial a memória, ao comprometimento da capacidade de desempenhar atividades da vida diária e à ocorrência de distúrbios comportamentais e de sintomas neuropsiquiátricos. Neste contexto o Enfermeiro pela sua formação especifica, pode atuar como orientador/educador, e privilegiando as orientações relacionadas ao tratamento com Cannabis Medicinal, bem como prestar assistência ao paciente e família. Objetivo: Atuação do Enfermeiro da Estratégia de Saúde da Família no tratamento alternativo com Cannabis Medicinal na doença de Alzheimer, e ressaltar as propriedades medicinais da Cannabis, esclarecer o funcionamento do sistema endocanabinoide, dando enfoque na atuação do Enfermeiro, propor um modelo de fluxograma para os Enfermeiros, orientando a família sobre o tratamento alternativo, com Cannabis Medicinal. Material e Método: Trata-se de uma pesquisa de revisão bibliográfica, de caráter descritivo com análise qualitativa. Para o levantamento de dados foram utilizadas as bases de dados Scielo e PudMed com critério de inclusão: artigos originais, publicações em português, inglês e espanhol, disponível na integra online, período de pesquisa de março a setembro de 2021. A amostra foi constituída de 15 artigos. Resultados: Nesse contexto analisamos que o Enfermeiro da ESF tem condições/conhecimento científico sobre o tratamento alternativo, e diante disso 26,6% dos artigos analisados falam que a atuação do Enfermeiro é fundamental, 40% dos artigos analisados falam que o tratamento alternativo com Cannabis Medicinal é algo promissor. Diante foi proposto um fluxograma evidenciando a atuação do Enfermeiro que durante a visita domiciliar pode informar a família sobre o tratamento, informando sobre as possíveis melhoras nas atividades de vida diária do cliente. Conclusão: As evidências sobre o tratamento com Cannabis, ressalta que o tratamento vem sendo cada dia mais promissor no âmbito medicinal, trazendo inúmeros benefícios para doenças neurológicas, como Alzheimer, e que o Enfermeiro tem papel fundamental como educador e orientador familiar, pois durante as visitas domiciliares existe uma relação de confiança entre o Enfermeiro–paciente–família.

Terpene Research Is Providing New Inspiration for Scientists

This current Special Issue of Molecules gathers selected communications on terpenes and terpene derivatives, clearly demonstrating the sustained interest in and importance of natural products in this field; fields connected to secondary metabolites; and renewable resources of plant and animal compounds for medicinal, material, supramolecular, and general chemistry research [...]

BmK86-P1, a New Degradation Peptide with Desirable Thermostability and Kv1.2 Channel-Specific Activity from Traditional Chinese Scorpion Medicinal Material

Thermally processed Buthus martensii Karsch scorpions are a traditional Chinese medical material for treating various diseases. However, their pharmacological foundation remains unclear. Here, a new degraded peptide of scorpion toxin was identified in Chinese scorpion medicinal material by proteomics. It was named BmK86-P1 and has six conserved cysteine residues. Homology modeling and circular dichroism spectra experiments revealed that BmK86-P1 not only contained representative disulfide bond-stabilized α-helical and β-sheet motifs but also showed remarkable stability at test temperatures from 20–95 °C. Electrophysiology experiments indicated that BmK86-P1 was a highly potent and selective inhibitor of the hKv1.2 channel with IC50 values of 28.5 ± 6.3 nM. Structural and functional dissection revealed that two residues of BmK86-P1 (i.e., Lys19 and Ile21) were the key residues that interacted with the hKv1.2 channel. In addition, channel chimeras and mutagenesis experiments revealed that three amino acids (i.e., Gln357, Val381 and Thr383) of the hKv1.2 channel were responsible for BmK86-P1 selectivity. This research uncovered a new bioactive peptide from traditional Chinese scorpion medicinal material that has desirable thermostability and Kv1.2 channel-specific activity, which strongly suggests that thermally processed scorpions are novel peptide resources for new drug discovery for the Kv1.2 channel-related ataxia and epilepsy diseases.

Links of Biomass of (Smilax Scobinicaulis) Dry Leaves and Daily Solar Radiation

(Smilax scobinicaulis) not only is a vital medicinal material plant by treating joint pain, but also it is a widely distributed wide plant species from 500m to 3100m in Mei County of China. However, understanding links between total biomass of dry leaves and daily solar radiation is difficult. This study explained that it is an increasing of total biomass of dry leaves with increasing of daily solar radiation as well as links between total biomass of dry leaves and daily solar radiation is the significant positive connection from 20.578mol/m2•d to 24.158mol/m2•d along elevation from 500m to 1500m (P<0.01); it is a decreasing of this total biomass of dry leaves with increasing of daily solar radiation as well as the links between this total biomass of dry leaves and daily solar radiation is a significant negative connection from 24.15mol/m2•d to 27.246mol/m2•d along elevation from 1500m to 3100m (P<0.01). This research provides a series of areas ecological adaptation of daily solar radiation and six landscapes of this species. Therefore, this has vital theoretical and practical significance by medicinal plant species protection for better future of human health, ecosystem services and ecosystem functions along daily solar radiation gradient.

Poria cum Radix Pini Rescues Barium Chloride-Induced Arrhythmia by Regulating the cGMP-PKG Signalling Pathway Involving ADORA1 in Zebrafish

The traditional Chinese medicine Poria cum Radix Pini (PRP) is a fungal medicinal material that has been proven to play an important role in the treatment of arrhythmia. However, the mechanism of its effect on arrhythmia is still unclear. In this study, network pharmacology and metabolomics correlation analysis methods were used to determine the key targets, metabolites and potential pathways involved in the effects of PRP on arrhythmia. The results showed that PRP can significantly improve cardiac congestion, shorten the SV-BA interval and reduce the apoptosis of myocardial cells induced by barium chloride in zebrafish. By upregulating the expression of the ADORA1 protein and the levels of adenosine and cGMP metabolites in the cGMP-PKG signalling pathway, PRP can participate in ameliorating arrhythmia. Therefore, we believe that PRP shows great potential for the treatment of arrhythmia.