Left anterior subregion of orbitofrontal cortex volume reduction and impaired organizational strategies in obsessive-compulsive disorder

The book will be valuable for those in the fields of neuroscience, neurology, psychology, psychiatry, biology, animal behaviour, economics, and philosophy, from the undergraduate level upwards. The book is unique in providing a coherent multidisciplinary approach to understanding the functions of one of the most interesting regions of the human brain, in both health and in disease, including depression, bipolar disorder, autism, and obsessive-compulsive disorder. There is no competing book published in the last 10 years.

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Recurrent hyperperfusion in the right orbitofrontal cortex in obsessive–compulsive disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2008.02.006 ◽

2008 ◽

Vol 32 (4) ◽

pp. 1082-1084 ◽

Cited By ~ 2

Author(s):

Ryohei Matsumoto ◽

Takashi Nakamae ◽

Takafumi Yoshida ◽

Yurinosuke Kitabayashi ◽

Yo Ushijima ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Orbitofrontal Cortex ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

The Right

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Repeated Cortico-Striatal Stimulation Generates Persistent OCD-Like Behavior

Science ◽

10.1126/science.1234733 ◽

2013 ◽

Vol 340 (6137) ◽

pp. 1234-1239 ◽

Cited By ~ 271

Author(s):

Susanne E. Ahmari ◽

Timothy Spellman ◽

Neria L. Douglass ◽

Mazen A. Kheirbek ◽

H. Blair Simpson ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Orbitofrontal Cortex ◽

Progressive Increase ◽

Repetitive Behaviors ◽

Mouse Behavior ◽

First Line ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Chronic Fluoxetine

Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used optogenetics in mice to simulate CSTC hyperactivation observed in OCD patients. Whereas acute orbitofrontal cortex (OFC)–ventromedial striatum (VMS) stimulation did not produce repetitive behaviors, repeated hyperactivation over multiple days generated a progressive increase in grooming, a mouse behavior related to OCD. Increased grooming persisted for 2 weeks after stimulation cessation. The grooming increase was temporally coupled with a progressive increase in light-evoked firing of postsynaptic VMS cells. Both increased grooming and evoked firing were reversed by chronic fluoxetine, a first-line OCD treatment. Brief but repeated episodes of abnormal circuit activity may thus set the stage for the development of persistent psychopathology.

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Do organizational strategies mediate nonverbal memory impairment in drug-naïve patients with obsessive-compulsive disorder?

Neuropsychology ◽

10.1037/a0018653 ◽

2010 ◽

Vol 24 (4) ◽

pp. 527-533 ◽

Cited By ~ 11

Author(s):

Na Young Shin ◽

Do-Hyung Kang ◽

Jung-Seok Choi ◽

Myung Hun Jung ◽

Joon Hwan Jang ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Memory Impairment ◽

Organizational Strategies ◽

Obsessive Compulsive ◽

Nonverbal Memory ◽

Compulsive Disorder ◽

Drug Naïve

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Organizational strategies mediate nonverbal memory impairment in obsessive–compulsive disorder

Biological Psychiatry ◽

10.1016/s0006-3223(98)00278-9 ◽

1999 ◽

Vol 45 (7) ◽

pp. 905-916 ◽

Cited By ~ 260

Author(s):

Cary R Savage ◽

Lee Baer ◽

Nancy J Keuthen ◽

Halle D Brown ◽

Scott L Rauch ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Memory Impairment ◽

Organizational Strategies ◽

Obsessive Compulsive ◽

Nonverbal Memory ◽

Compulsive Disorder

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Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive–compulsive disorder

Brain Structure and Function ◽

10.1007/s00429-018-1752-8 ◽

2018 ◽

Vol 224 (1) ◽

pp. 191-203 ◽

Cited By ~ 4

Author(s):

Katia Cristina de Oliveira ◽

Lea Tenenholz Grinberg ◽

Marcelo Queiroz Hoexter ◽

Helena Brentani ◽

Claudia Kimie Suemoto ◽

...

Keyword(s):

Older Adults ◽

Obsessive Compulsive Disorder ◽

Orbitofrontal Cortex ◽

Obsessive Compulsive ◽

Neuronal Density ◽

Compulsive Disorder

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Mapping Alterations of the Functional Structure of the Cerebral Cortex in Obsessive–Compulsive Disorder

Cerebral Cortex ◽

10.1093/cercor/bhz008 ◽

2019 ◽

Vol 29 (11) ◽

pp. 4753-4762 ◽

Cited By ~ 4

Author(s):

Jesus Pujol ◽

Laura Blanco-Hinojo ◽

Dídac Maciá ◽

Pino Alonso ◽

Ben J Harrison ◽

...

Keyword(s):

Cerebral Cortex ◽

Obsessive Compulsive Disorder ◽

Neural Activity ◽

Orbitofrontal Cortex ◽

Inhibitory Neuron ◽

Functional Structure ◽

Neuron Activity ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Neurophysiological Studies

AbstractWe mapped alterations of the functional structure of the cerebral cortex using a novel imaging approach in a sample of 160 obsessive–compulsive disorder (OCD) patients. Whole-brain functional connectivity maps were generated using multidistance measures of intracortical neural activity coupling defined within isodistant local areas. OCD patients demonstrated neural activity desynchronization within the orbitofrontal cortex and in primary somatosensory, auditory, visual, gustatory, and olfactory areas. Symptom severity was significantly associated with the degree of functional structure alteration in OCD-relevant brain regions. By means of a novel imaging perspective, we once again identified brain alterations in the orbitofrontal cortex, involving areas purportedly implicated in the pathophysiology of OCD. However, our results also indicated that weaker intracortical activity coupling is also present in each primary sensory area. On the basis of previous neurophysiological studies, such cortical activity desynchronization may best be interpreted as reflecting deficient inhibitory neuron activity and altered sensory filtering.

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