Repeated implantation failure: Immunological aspects and evidence based treatment modalities

2009 ◽  
Vol 81 (2) ◽  
pp. 120-121
Author(s):  
A. Makrigiannakis
Keyword(s):  
Treatment Modalities ◽  
Evidence Based ◽  
Implantation Failure ◽  
Repeated Implantation Failure ◽  
Evidence Based Treatment

scholarly journals Evidence-based treatment of osteoporotic vertebral compression fracture

2021 ◽  
Vol 64 (3) ◽  
pp. 200-207
Author(s):  
Subum Lee ◽  
Dae-Chul Cho ◽  
Kyong-Tae Kim ◽  
Young-Seok Lee
Keyword(s):  
Surgical Treatment ◽  
Outcome Measurement ◽  
Treatment Guideline ◽  
Treatment Modalities ◽  
Vertebral Compression Fractures ◽  
Controlled Trials ◽  
Evidence Based ◽  
Evidence Based Treatment ◽  
Significant Difference ◽  
Non Surgical Treatment

The prevalence and medical costs of osteoporotic vertebral compression fractures (OVCFs) are on the rise. However, a concrete evidence-based treatment guideline has not yet been established. Despite that numerous randomized controlled trials (RCTs) were performed, the study design and outcome measurement were heterogeneous, and the results were not unified. The purpose of this review is to compare the results of high level-evidence studies to provide a background for evidence-based OVCF treatment. Many reports showed that vertebroplasty has better clinical outcomes than non-surgical treatment for OVCF, but the results of three double-blinded RCTs with the highest level of evidence did not show a significant difference between vertebroplasty and sham procedure. Whether undergoing surgical or non-surgical treatment, OVCF patient management should be started by managing osteoporosis first. Meanwhile, in the results of RCTs related to the comparison of conservative treatment modalities, the benefit of braces and a specific analgesic prescription protocol was also unclear. The presented results of each clinical trial were generally inconsistent and may not be appropriate in all situations. Any decision by clinicians to apply this evidence must be made considering individual patients and available resources. At present, controversy remains about the best treatment modality for OVCF. Large, multicenter, placebo/sham-controlled trials are needed to address this gap and establish strong evidence-based guidelines.

scholarly journals Evidence based treatment of hemorrhoids

2008 ◽  
Vol 55 (3) ◽  
pp. 127-132 ◽  
Author(s):  
A. Tamelis ◽  
T. Latkauskas ◽  
D. Pavalkis ◽  
Z. Saladinskas ◽  
S. Vagdys
Keyword(s):  
Treatment Modalities ◽  
Evidence Based ◽  
Level Of Evidence ◽  
Evidence Based Treatment ◽  
Proof Of Efficacy

A number of different hemorrhoids? treatment modalities were introduced and discussed during last two decades. Different level of evidence supports one or another approach and new data emerge constantly. Decision to apply particular method of treatment force clinicians to make thorough judgment. The article presents the newest data about different aspects of hemorrhoids management focusing on proof of efficacy.

A search in the surge of treatment for COVID-19 patients: A narrative literature review

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 822-831
Author(s):  
Sridevi Ugrappa ◽  
Ajay Jain ◽  
Akshay Bhargava ◽  
Neeraj Kumar Fuloria ◽  
Shivkanya Fuloria
Keyword(s):  
Immune Therapy ◽  
Treatment Strategies ◽  
Signs And Symptoms ◽  
Treatment Modalities ◽  
Evidence Based ◽  
Evidence Based Treatment ◽  
Pubmed Search ◽  
Blood Purification Therapy ◽  
Narrative Literature ◽  
Narrative Literature Review

Today, our understanding towards COVID-19 pandemic is that it is contagious and based on the of the virus, the signs and symptoms of this viral resemble the viral infectionlike Severe Acute-Respiratory (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV). Currently, documented vaccines or drugs are not available for the treatment of COVID-19, SARS-CoV-2 viral infection. The main objective of this article is to compile the available literature on the treatment modalities for COVID-19, currently being advocated. Furthermore, there is no time to wait for evidence-based treatment, hence in such a scenario; an attempt has been made to collect the available scientific literature and understand the treatment of the disease with this insight. A MEDLINE-PUBMED search was performed in the surge of the treatment strategies for COVID-19 using the keywords "COVID-19", "", "novel ", "treatment of " and "therapies". We have reviewed the multiple articles from recently published literature and various proofs from up-to-date journals. Based on the reviewed literature, various categories of drugs are under trial or have been tried for the treatment of infection, which are as medications (anti-viral agents, and , ACE-2 inhibitors, etc.), immune therapy, traditional Chinese medicine, plasma exchange therapy, and blood purification therapy, etc. We attempted to go through the literature available for the treatment of COVID-19 and tried to compile it all together. Still, clinical trials are under process, and there are no evidence-based treatment strategies available to manage the cases of COVID-19 patients.

scholarly journals Venous Thromboembolism – Current Diagnostic and Treatment Modalities

2016 ◽  
Vol 4 (3) ◽  
pp. 523-525 ◽  
Author(s):  
Marijan Bosevski ◽  
Elizabeta Srbinovska-Kostovska
Keyword(s):  
Venous Thromboembolism ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
Clinical Information ◽  
Treatment Modalities ◽  
Evidence Based ◽  
Evidence Based Treatment ◽  
Therapeutic Modalities ◽  
Single Drug ◽  
A Current

BACKGROUND: Pulmonary embolism and deep venous thrombosis, known as venous thromboembolism (VTE), are associated with a high proportion of morbidity and mortality.AIM: Aim of this review is to emphasise current diagnostic and therapeutic modalities for VTE.RESULTS: No differences have been noticed in European and American guidelines in diagnostic approach of this disorder. Today there is enough clinical information for the use of heparin (either, unfractionated or low molecular) and vitamin K antagonists in the treatment of acute and chronic phases of VTE. Novel oral anticoagulants seem to have some advantages in the treatment of this disorder. Rivaroxaban has been approved widespread, for use as a single-drug approach of VTE.CONCLUSION: Both guidelines are almost similar and good basis for evidence-based treatment of this disorder.

scholarly journals Bilateral Porokeratosis Ptychotropica on the Gluteal Cleft: A Case Report and Review of the Literature

2019 ◽  
Vol 3 (6) ◽  
pp. 427-430
Author(s):  
Roya S. Nazarian ◽  
Nikki Vyas ◽  
Noah Scheinfeld ◽  
Robert G. Phelps
Keyword(s):  
Squamous Cell Carcinoma ◽  
Clinical Presentation ◽  
Standard Of Care ◽  
Treatment Modalities ◽  
Evidence Based ◽  
Review Of The Literature ◽  
Limited Evidence ◽  
Evidence Based Treatment ◽  
Proper Diagnosis ◽  
Porokeratosis Ptychotropica

Porokeratosis ptychotropica (PP) is a rare variant of porokoretosis that is distinctive based on its clinical presentation of pruritic, verrucous papules and plaques that often form a “butterfly” shape, commonly located on the perinatal cleft with extension to the buttocks. Similar to other variants of porokeratosis, it is histologically distinguished by the presence of cornoid lamellae. Proper diagnosis is necessary as some studies suggest that PP may predispose to squamous cell carcinoma. Furthermore, there are limited evidence-based treatment options.We report the case of a47 year-old-male who presented with a rash on the buttocks and legs for 3 years. Physical exam revealed erythematous, annular, and verrucous plaques on the bilateral periglueteal area and bilateral distal lower extremities. The patient felt that lesions on the legs were disfiguring but otherwise asymptomatic. Biopsy results demonstrated hyperkeratosis and parakeratosis suggestive of cornoid lamellae. Clinical and histologic findings were suggestive of PP. Lesions on the legs were treated with cryotherapy, which resulted in resolution at a 3-month follow-up.PP remains a diagnostic and therapeutic challenge due to its rarity. No standard of care has been established, though topical calcipotriol, topical imiquimod, topical tretonoin, and cryotherapy have been used with success in the literature. This case highlights unique characteristics of PP in order to aid in early detection and cancer prevention while also describing various treatment modalities.

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