Vitamin D kinetics in nonpregnant and pregnant women after a single oral dose of trideuterated vitamin D3

2021 ◽  
pp. 106034
Author(s):  
Cora M. Best ◽  
Robert Sherwood ◽  
Janet A. Novotny ◽  
Sheng Zhang ◽  
Eva K. Pressman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Oral Dose ◽  
Pregnant Women ◽  
Single Oral Dose ◽  
Vitamin D3

The Effects of a Diphosphonate and Dietary Calcium on the Metabolism of Vitamin D3 (Cholecalciferol) in the Chick

1975 ◽  
Vol 49 (5) ◽  
pp. 391-400
Author(s):  
Carol M. Taylor ◽  
E. Barbara Mawer ◽  
A. Reeve
Keyword(s):  
Vitamin D ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Vitamin D3 ◽  
Dietary Calcium ◽  
No Inhibition ◽  
25 Hydroxycholecalciferol

1. Vitamin D-deficient chicks, maintained on a diet adequate in calcium and treated with ethane-1-hydroxy-1,1-diphosphonate for 2 days before a single oral dose of cholecalciferol (vitamin D3), converted the vitamin into 24,25-dihydroxycholecalciferol instead of into the normal metabolite 1,25-dihydroxycholecalciferol. 2. This inhibition of the renal 1-hydroxylase disappeared on withdrawal of the diphosphonate. 3. Kidneys from chicks given diphosphonate for 12 days converted 25-hydroxycholecalciferol into 24,25-dihydroxycholecalciferol on incubation in vitro. 4. The inhibition of the 1-hydroxylase was markedly accelerated by treating the birds with cholecalciferol. 5. No inhibition of renal 1-hydroxylation was observed in birds maintained on a diet low in calcium. 6. A possible mechanism producing this effect is discussed.

scholarly journals Pharmacokinetics of a single oral dose of vitamin D3 (70,000 IU) in pregnant and non-pregnant women

2012 ◽  
Vol 11 (1) ◽  
Author(s):  
Daniel E Roth ◽  
Abdullah Al Mahmud ◽  
Rubhana Raqib ◽  
Robert E Black ◽  
Abdullah H Baqui
Keyword(s):  
Oral Dose ◽  
Pregnant Women ◽  
Single Oral Dose ◽  
Vitamin D3

scholarly journals Impact of a single oral dose of 100,000 IU vitamin D3 on profiles of serum 25(OH)D3 and its metabolites 24,25(OH)2D3, 3-epi-25(OH)D3, and 1,25(OH)2D3 in adults with vitamin D insufficiency

2017 ◽  
Vol 55 (12) ◽  
Author(s):  
Lanja Saleh ◽  
Jonathan Tang ◽  
Joanna Gawinecka ◽  
Lukas Boesch ◽  
William D. Fraser ◽  
...  
Keyword(s):  
Vitamin D ◽  
Oral Dose ◽  
Vitamin D3 ◽  
Vitamin D Insufficiency ◽  
High Dose ◽  
Serum Concentrations ◽  
Single High Dose ◽  
Metabolite Concentrations ◽  
Study Participants ◽  
To Receive

AbstractBackground:We investigate the effect of a high dose of vitamin D3 on circulating concentrations of 25(OH)D3 and its metabolites 24,25(OH)Methods:One hundred and seven study participants (age 20–50 years) were randomized to receive a single 100,000 IU dose of vitamin D3 (n=52) or placebo (n=55). Vitamin D metabolite concentrations in serum were measured before, and 4 weeks after, supplementation.Results:Overall, 52% of participants receiving vitamin D3 attained a serum 25(OH)D3 level >75 nmol/L. Among individuals who received vitamin D3, there were significant increases in serum concentrations of 25(OH)D3 and its metabolites 24,25(OH)Conclusions:Administration of a single high dose of vitamin D3 leads to a significant increase in concentrations of 25(OH)D3, 24,25(OH)

Effect of vitamin D3 supplementation during pregnancy on high risk factors - a randomized controlled trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Jiang Xiaomang ◽  
Wei Yanling
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D3 ◽  
Low Dose ◽  
Controlled Trial ◽  
Reduction Rate ◽  
Dose Effect ◽  
High Dose ◽  
Vitamin D Levels ◽  
Vitamin D3 Supplementation

AbstractObjectivesVitamin D plays an important role in the release of the placenta and implantation, and low levels are a risk factor for pre-eclampsia. Studies have also shown that symptomatic treatment of vitamin D3 deficiency can effectively reduce the risk of pre-eclampsia. In this study, vitamin D3 supplementation was performed on the risk of pre-eclampsia to observe its effect.MethodsFrom January 2016 to December 2018, 450 women with maternal treatment and delivery in our hospital underwent an open-label randomized study. The pregnant women were divided into low-dose, medium-dose, and high-dose groups. Compare the incidence of pre-eclampsia and the dose effect of vitamin D levels.ResultsIn the maternal and perinatal periods of the 450 maternal women, the 25[OH] index of the three groups of pregnant women was significantly increased, while the high-dose increase index was more obvious. The relative risk reduction rate was significantly lower. Compared with the low-dose and middle-dose groups, the high-dose group had a significantly lower incidence of pre-eclampsia, while the IUGR index was lower, and other obstetric indicators were comparable.ConclusionVitamin D supplementation can effectively reduce the incidence of pre-eclampsia, while reducing the IUGR index, which has important value and significance in its clinical application.

scholarly journals Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2517
Author(s):  
Otilia Perichart-Perera ◽  
Carla Patricia González-Leyva ◽  
Isabel González-Ludlow ◽  
Maricruz Tolentino-Dolores ◽  
Mario Solis-Paredes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Mexican Women ◽  
Vitamin D Status ◽  
Third Trimester ◽  
Maternal Vitamin ◽  
The Third ◽  
Maternal Vitamin D Status

Controversy remains surrounding vitamin D routine supplementation in healthy pregnancy, and the doses are unclear. The aim of this study was to describe maternal vitamin D status throughout pregnancy in a group of Mexican women and evaluate the effect of frequently prescribed doses of vitamin D3 on longitudinal 25-OH-D concentrations, adjusting for obesity, season, and other factors. We conducted a cohort study (Instituto Nacional de Perinatología-INPer) (2017–2020)) of healthy pregnant women without complications. Pregestational overweight/obesity (body mass index ≥ 25), vitamin D3 supplementation (prescribed by physician; 0–250, 250–400, and >400 IU/day), and serum 25-OH-D concentrations (ELISA) were evaluated in each trimester of pregnancy. Vitamin D deficiency or insufficiency was computed (<20 and <30 ng/mL, respectively). We studied 141 adult women; 58.5% had pregestational obesity or overweight. In the first trimester, 45.8% of the women were supplemented with vitamin D3; 51.4% had vitamin D insufficiency and 37.3%, deficiency. In the third trimester, 75.4% of the women were supplemented, and 20% of them still had deficiency. The final general mixed linear model showed that 25-OH-D significantly increased throughout pregnancy (p < 0.001); the highest increase was observed in the third trimester in women with doses >400 IU/day of vitamin D3 (+4 ng/mL, 95% CI: 1.72–8.11 ng/mL). In winter/autumn, 25-OH-D concentrations were also lower (p ≤ 0.05). In this group of pregnant Mexican women, the prevalence of vitamin D deficiency and insufficiency was high. A higher increase in 25-OH-D concentrations during pregnancy was observed when the women were supplemented with >400 IU/day. Common supplementation doses of 250–400 IU/day were insufficient for achieving an adequate maternal vitamin D status.

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