Age-related effect of a single oral dose of calcium on parathyroid function: relationship with vitamin D status

1994 ◽  
Vol 60 (3) ◽  
pp. 403-407 ◽  
Author(s):  
J Guillemant ◽  
F Oberlin ◽  
P Bourgeois ◽  
S Guillemant
2015 ◽  
Vol 133 (10) ◽  
pp. 1171 ◽  
Author(s):  
Amy E. Millen ◽  
Kristin J. Meyers ◽  
Zhe Liu ◽  
Corinne D. Engelman ◽  
Robert B. Wallace ◽  
...  

2009 ◽  
Vol 24 (4) ◽  
pp. 693-701 ◽  
Author(s):  
Natalia O Kuchuk ◽  
Natasja M van Schoor ◽  
Saskia M Pluijm ◽  
Arkadi Chines ◽  
Paul Lips

Author(s):  
Betsy Szeto ◽  
Chris Valentini ◽  
Anil K Lalwani

ABSTRACT Background The elderly are at increased risk of both hearing loss (HL) and osteoporosis. Bone mineral density (BMD) has been putatively linked to HL. However, the roles of serum calcium concentrations and vitamin D status have yet to be elucidated. Objectives The purpose of this study was to examine the relation between vitamin D status, parathyroid hormone (PTH), total calcium, BMD, and HL in a nationally representative sample of elderly adults. Methods Using the NHANES (2005–2010), audiometry and BMD data of 1123 participants aged ≥70 y were analyzed in a cross-sectional manner. HL was defined as pure tone averages >25 dB HL at 500, 1000, and 2000 Hz (low frequency); 500, 1000, 2000, and 4000 Hz (speech frequency); and 3000, 4000, 6000, and 8000 Hz (high frequency) in either ear. Multivariable logistic regression was used to examine the relation between HL and total 25-hydroxyvitamin D [25(OH)D], PTH, total calcium, and BMD, adjusting for covariates. Results In multivariable analyses, total 25(OH)D < 20 ng/mL was found to be associated with greater odds of low-frequency HL (OR: 2.02; 95% CI: 1.28, 3.19) and speech-frequency HL (OR: 1.96; 95% CI: 1.12, 3.44). A 1-unit decrease in femoral neck BMD (OR: 4.55; 95% CI: 1.28, 16.67) and a 1-unit decrease in total spine BMD (OR: 6.25; 95% CI: 1.33, 33.33) were found to be associated with greater odds of low-frequency HL. Serum PTH and total calcium were not found to be associated with HL. Conclusions In the elderly, low vitamin D status was associated with low-frequency and speech-frequency HL. Low vitamin D status may be a potential risk factor for age-related HL.


Author(s):  
Cora M. Best ◽  
Robert Sherwood ◽  
Janet A. Novotny ◽  
Sheng Zhang ◽  
Eva K. Pressman ◽  
...  

2013 ◽  
Vol 111 (1) ◽  
pp. 23-45 ◽  
Author(s):  
Jennifer Hilger ◽  
Angelika Friedel ◽  
Raphael Herr ◽  
Tamara Rausch ◽  
Franz Roos ◽  
...  

Vitamin D deficiency is associated with osteoporosis and is thought to increase the risk of cancer and CVD. Despite these numerous potential health effects, data on vitamin D status at the population level and within key subgroups are limited. The aims of the present study were to examine patterns of 25-hydroxyvitamin D (25(OH)D) levels worldwide and to assess differences by age, sex and region. In a systematic literature review using the Medline and EMBASE databases, we identified 195 studies conducted in forty-four countries involving more than 168 000 participants. Mean population-level 25(OH)D values varied considerably across the studies (range 4·9–136·2 nmol/l), with 37·3 % of the studies reporting mean values below 50 nmol/l. The highest 25(OH)D values were observed in North America. Although age-related differences were observed in the Asia/Pacific and Middle East/Africa regions, they were not observed elsewhere and sex-related differences were not observed in any region. Substantial heterogeneity between the studies precluded drawing conclusions on overall vitamin D status at the population level. Exploratory analyses, however, suggested that newborns and institutionalised elderly from several regions worldwide appeared to be at a generally higher risk of exhibiting lower 25(OH)D values. Substantial details on worldwide patterns of vitamin D status at the population level and within key subgroups are needed to inform public health policy development to reduce risk for potential health consequences of an inadequate vitamin D status.


1988 ◽  
Vol 67 (4) ◽  
pp. 644-650 ◽  
Author(s):  
P. LIPS ◽  
A. WIERSINGA ◽  
F. C. VAN GINKEL ◽  
M. J. M. JONGEN ◽  
J. C. NETELENBOS ◽  
...  

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