Carbon tetrachloride (CCl4) a pharmacological tool was used to induce liver damage in Wistar albino rats. Silymarin (100 mg/kg) and
methanol extract of Lawsonia inermis Linn. family Lythraceae (known to possess hepatoprotective compounds) was used to reverse
the liver damage caused due to CCl4 (induced toxicity). Hydroalcholic extract of stem bark and leaf of Lawsonia inermis Linn. was
evaluated, for its restorative efficacy against CCl4 induced hepatotoxicity which was assessed in terms of biochemical and
histopathological parameters. CCl4 produce the altitude levels of serum marker enzymes of alanine aminotransferase (ALT), asparate
aminotransferase (AST), alanine phosphatase (ALP) and bilirubin in blood serum. Due to the toxicity of CCl4 cause turbine hepatic cell
architecture, necrosis, inflammatory cell infiltration, congestion, and sinusoidal dilatation along with reduction of superoxide
dismutase (SOD), catalase, Glutathione-S-transferase (GST) and glutathione peroxidase (GPx) appeared in liver tissue. SOD is the
primary step in the defense mechanism involved in the antioxidant system against the oxidative stress. It diminishes by converting
the superoxide radical in to peroxide and molecular oxygen. CAT or GPx reactions, also exert a similar effect thereby reducing the
level of cellular damage. By oral administration of methanol extract of Lawsonia inermis Linn. plant extracts, i.e., stem bark extract
(250 mg/kg b.wt.) and leaf extract (250 mg/kg b. wt.) the levels of these parameters was restored to near controlled (untreated)
levels. Thus, the present study revealed that the extracts of stem bark and leaf of Lawsonia inermis Linn. offered protection against
hepatotoxicity induced by CCl4.
Chemical constituents and protective effect of Ficus ingens (Miq.) Miq. on carbon tetrachloride-induced acute liver damage in male Wistar albino rats
