A Case-Control Study of Body Composition, Prevalence, and Curve Severity of the Patients With Adolescent Idiopathic Scoliosis in the East Part of China

2017 ◽  
Vol 5 (6) ◽  
pp. 374-380 ◽  
Author(s):  
Yu Zheng ◽  
Yini Dang ◽  
Yan Yang ◽  
Ning Sun ◽  
Tao Wang ◽  
...  
Keyword(s):  
Body Composition ◽  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Case Control Study ◽  
Case Control ◽  
East Part ◽  
Curve Severity ◽  
Control Study

scholarly journals The Association Study of Calmodulin 1 Gene Polymorphisms with Susceptibility to Adolescent Idiopathic Scoliosis

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Yu Zhang ◽  
Zuchao Gu ◽  
Guixing Qiu
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Case Control Study ◽  
Case Control ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Curve Severity ◽  
The Relationship ◽  
Control Study ◽  
Main Curve

Objective.Idiopathic scoliosis is the most common pediatric spinal deformity affecting 1% to 3% of the population, and adolescent idiopathic scoliosis (AIS) accounts for approximately 80% of these cases; however, the etiology and pathogenesis of AIS are still uncertain. The current study aims to identify the relationship between calmodulin 1 (CALM1) gene and AIS predisposition, to identify the relationship between the genotypes of the SNPs and the clinical phenotypes of AIS.Methods.146 AIS patients and 146 healthy controls were enrolled into this case-control study. 12 single nucleotide polymorphisms (SNPs) candidates in CALM1 gene were selected to determine the relationship between CALM1 gene and AIS predisposition. Case-only study was performed to determine the effects of these variants on the severity of the condition.Results.Three SNPs from 12 candidates were found to be associated with AIS predisposition. The ORs were observed as 0.549 (95% CI 0.3519–0.8579,P=0.0079), 0.549 (95% CI 0.3519–0.8579,P=0.0079), and 1.6139 (95% CI 1.0576–2.4634,P=0.0257) for rs2300496, rs2300500, and rs3231718, respectively. There was no statistical difference between main curve, severity, and genotype distributions of all of 12 SNPs.Conclusion.Genetic variants of CALM1 gene are associated with AIS susceptibility.

scholarly journals Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Svetla Nikolova ◽  
Milka Dikova ◽  
Dobrin Dikov ◽  
Assen Djerov ◽  
Gyulnas Dzhebir ◽  
...  
Keyword(s):  
Idiopathic Scoliosis ◽  
Case Control Study ◽  
Early Stage ◽  
Promoter Polymorphism ◽  
Case Control ◽  
Chi Squared ◽  
Bulgarian Population ◽  
Deformity Progression ◽  
Curve Severity ◽  
Control Study

Scoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6). The G/C polymorphism of the promoter region ofIL-6gene influences levels and functional activity of the IL-6 protein. We conducted a case-control study of eighty patients with idiopathic scoliosis (IS) and one hundred sixty healthy unrelated gender-matched controls trying to investigate the association between IS and theIL-6promoter polymorphism at -174 position (rs1800795 G/C) in Bulgarian population. Molecular detection of theIL-6genotypes was performed by amplification followed by restriction technology. The statistical analysis was performed by Pearson’s chi-squared test. Our case-control study revealed a statistically significant association between theIL-6(-174 G/C) functional polymorphism and susceptibility to IS. In addition, a significant association between theIL-6(-174 G/C) polymorphism and curve severity was detected.IL-6gene could be considered as susceptibility and modifying factor of idiopathic scoliosis. The identification of molecular markers with diagnostic and prognostic value could be useful for early detection of children at risk for the development of scoliosis and for prognosis of the risk for a rapid deformity progression. That would facilitate the therapy decisions and early stage treatment of the patient with the least invasive procedures.

scholarly journals Evaluating bone strength with finite element analysis for Adolescent Idiopathic Scoliosis (AIS): a case-control study with HR-pQCT

Scoliosis ◽  
2015 ◽  
Vol 10 (S1) ◽  
Author(s):  
Ka Yee Cheuk ◽  
Tsz Ping Lam ◽  
Lyn Lee Ning Wong ◽  
Alec Lik Hang Hung ◽  
Arthur Fuk Tat Mak ◽  
...  
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Bone Strength ◽  
Case Control Study ◽  
Case Control ◽  
Element Analysis ◽  
Control Study

scholarly journals The association between IL-6 and MMP-3 gene polymorphisms and adolescent idiopathic scoliosis: a case-control study

Scoliosis ◽  
2009 ◽  
Vol 4 (Suppl 1) ◽  
pp. O1
Author(s):  
Angelo Aulisa ◽  
E Pola ◽  
P Papaleo ◽  
Marco Galli ◽  
L Aulisa
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Control Study
Sign in / Sign up

Export Citation Format

Share Document