QS350. Synchronous Ovarian Metastases at the Time of Resection for Colon Cancer-Clinical and Pathologic Features

e14025 Background: Colorectal cancer is one of the most common malignancies in both men and women in Israel. Most patients with colon cancer are older than 50 years of age. However young patients are not rare. There is no consensus in the literature regarding the behavior of this disease in young patients. Clinical and pathological characteristics of colon cancer patients treated at Oncology Institute in Ziv Medical Center were retrospectively analyzed. The aim of the present study is to compare clinical and pathological features of colon cancer between young and old patients. Methods: A total of 200 patients with colon cancer were treated at our institute during 8 years. Twenty five (12.5%) of them were <50 years age (young patients) at diagnosis. All clinical and pathological characteristics were taken retrospectively from the hospital files. In situations where the pathological findings were not noted in the chart, review of the stored tumor was requested from the pathology department. Acceptable statistical methods were used for statistical calculations. Results: Among the 200 patients 25 (12.5%) were <50 years age at diagnosis (mean age 41 years) and 175 were >50 years (mean age 70 years). Males were 56% of the young group and 60.1% of the old one. Arab patients were 52% of the young and only 12.6% of the old group although total number of Arabs was 35 of 200 patients. No significant difference was found in stage of tumor at diagnosis between the young group (YG) and the old group (OG). Twenty percent of YG had distant metastases compared to 26.5% in the OG. Histopathological grade 3 tumors were found in 33.3% of the YG versus 7.7% in the OG. Surgery and chemotherapy were done in 96% and 88% in YG versus 95.4% and 69.7% in the OG respectively. In a median follow up period of 96 months 35% of young patients died of their disease compared to 33.1% of the old patients. Conclusions: Young patients with colon cancer were diagnosed at the same stage of the disease as old patients. More tumors were high grade in YG. More patients were candidates for chemotherapy in the YG. Significantly more Arab patients were young at the time of diagnosis than Jewish patients. Further studies with higher number of patients are suggested to clarify our findings.

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Manifestation of Bilateral Huge Ovarian Metastases from Colon Cancer Immediately After the Initial Operation: Report of a Case

Surgery Today ◽

10.1007/s005950200055 ◽

2002 ◽

Vol 32 (4) ◽

pp. 371-375 ◽

Cited By ~ 8

Author(s):

Chouhei Sakakura ◽

Akeo Hagiwara ◽

Dai Kato ◽

Takuo Hamada ◽

Hisakazu Yamagishi

Keyword(s):

Colon Cancer ◽

Initial Operation ◽

Ovarian Metastases

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Synchronous ovarian metastases at the time of laparotomy for colon cancer

Gynecologic Oncology ◽

10.1016/j.ygyno.2003.12.017 ◽

2004 ◽

Vol 92 (3) ◽

pp. 851-855 ◽

Cited By ~ 35

Author(s):

Jason D Wright ◽

Matthew A Powell ◽

David G Mutch ◽

Janet S Rader ◽

Randall K Gibb ◽

...

Keyword(s):

Colon Cancer ◽

Ovarian Metastases

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Association of HER2 expression with pathologic features and prognosis in stage II and III colon cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.3524 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. 3524-3524

Author(s):

Zehua Wu ◽

Huabin Hu ◽

Yanhong Deng

Keyword(s):

Colon Cancer ◽

High Risk ◽

Protein Expression ◽

Cancer Patients ◽

Stage Ii ◽

Stage Iii ◽

Prognostic Impact ◽

Her2 Expression ◽

Her2 Protein ◽

Pathologic Features

3524 Background: We examined the frequency, tumor characteristics, and prognostic impact of HER2 protein expression in stage II and III colon cancer after curative resection. Methods: Paraffin-embedded tumors from consecutive primary stage II and III colon cancer patients were analyzed for HER2 protein expression by immunohistochemistry between April, 2013 and May, 2020. HER2 determination of immunohistochemistry scores (0/1+/2+/3+) was according to HERACLES diagnostic criteria. Results: A total of 2088 stage II and III colon cancer patients were included (53.8% stage II, 46.3% stage III). HER2 scored positive (3+) was detected in 48(2.3%) tumors, and was correlated with younger age (P < 0.001), well/moderate differentiation (P = 0.026), proficient mismatch repair (pMMR) (P = 0.045) and KRAS wild-type (P < 0.001). HER2 scored positive (3+) was not significantly associated with disease-free survival (DFS) compared with HER2 scored negative (0/1+), neither in stage III patients (multivariable HR, 0.86; 95CI, 0.38 to 1.94; P = 0.717), nor in stage II patients (multivariable HR, 1.68; 95CI, 0.74 to 3.84; P = 0.218). In a separate analysis involving stage II patients without any high-risk factor (n = 741), those with HER2 scored positive (3+) tumors (n = 16) showed significantly reduced DFS (multivariable HR, 2.91; 95CI, 1.04 to 8.81; P = 0.041) compared with patients with HER2 scored negative (0/1+) tumors, independent of sex, age and MMR status. Conclusions: HER2 scored positive (3+) was independently associated with poor DFS in stage II colon cancer patients without high-risk factors. HER2 expression determination may help to judge the prognosis of those patients and guide adjuvant chemotherapy.

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Comparison of molecular and pathologic features of stage II and stage III colon cancer in four large studies conducted for development of the 12-gene colon cancer recurrence score.

Journal of Clinical Oncology ◽

10.1200/jco.2010.28.15_suppl.3503 ◽

2010 ◽

Vol 28 (15_suppl) ◽

pp. 3503-3503 ◽

Cited By ~ 7

Author(s):

M. J. O'Connell ◽

I. C. Lavery ◽

R. G. Gray ◽

P. Quirke ◽

D. J. Kerr ◽

...

Keyword(s):

Colon Cancer ◽

Cancer Recurrence ◽

Recurrence Score ◽

Stage Ii ◽

Stage Iii ◽

Stage Iii Colon Cancer ◽

Pathologic Features ◽

Colon Cancer Recurrence

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EP18.06: Sonographic features of ovarian metastases from colon cancer: the intracystic villous pattern

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.20052 ◽

2018 ◽

Vol 52 ◽

pp. 267-268

Author(s):

E. Lee

Keyword(s):

Colon Cancer ◽

Ovarian Metastases

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Molecular Profiling of Carcinoma of Unknown Primary and Correlation With Clinical Evaluation

Journal of Clinical Oncology ◽

10.1200/jco.2007.14.4378 ◽

2008 ◽

Vol 26 (27) ◽

pp. 4442-4448 ◽

Cited By ~ 168

Author(s):

Gauri R. Varadhachary ◽

Dmitri Talantov ◽

Martin N. Raber ◽

Christina Meng ◽

Kenneth R. Hess ◽

...

Keyword(s):

Colon Cancer ◽

Poor Response ◽

Response To Therapy ◽

Response To Treatment ◽

Unknown Primary ◽

Cancer Center ◽

Carcinoma Of Unknown Primary ◽

University Of Texas ◽

Pathologic Features ◽

Tissue Of Origin

Purpose To evaluate the feasibility of a 10-gene reverse transcriptase polymerase chain reaction assay to identify the tissue of origin in patients with carcinoma of unknown primary (CUP) site. Patients and Methods Diagnostic biopsy formalin-fixed, paraffin-embedded (FFPE) specimens from 120 patients with CUP were collected retrospectively from Sarah Cannon Research Institute, Nashville, TN, and prospectively from The University of Texas M. D. Anderson Cancer Center, Houston, TX. Tissue of origin assignments by the assay were correlated with clinical and pathologic features and with response to therapy. Results The assay was successfully performed in 104 patients (87%), and a tissue of origin was assigned in 63 patients (61%). In the remaining 41 patients (39%), the molecular profiles were not specific for the six tumor types detectable by this assay. The tissues of origin most commonly identified were lung, pancreas, and colon; most of these patients had clinical and pathologic features consistent with these diagnoses. Patients with lung and pancreas profiles had poor response to treatment. Patients with colon cancer profiles had better response to colon cancer–specific therapies than they did to empiric CUP therapy with taxane/platinum regimens. Patients with ovarian cancer profiles were atypical, with widespread visceral metastases and a paucity of overt peritoneal involvement. Conclusion This gene expression profiling assay was feasible using FFPE biopsy specimens and identified a putative tissue of origin in 61% of patients with CUP. In most patients, the assigned tissue of origin was compatible with clinicopathologic features and response to treatment. Prospective studies in which assay results are used to direct therapy are indicated.

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