A Dose-Response Relationship Between Sleep Duration and Stroke According to Nonhealth Status in Central China: A Population-based Epidemiology Survey

2019 ◽  
Vol 28 (7) ◽  
pp. 1841-1852 ◽  
Author(s):  
Qiaoyun Guo ◽  
Weihong Xie ◽  
Rui Peng ◽  
Yan Ma ◽  
Feifei Chong ◽  
...  
Keyword(s):  
Sleep Duration ◽  
Dose Response ◽  
Population Based ◽  
Central China ◽  
Response Relationship ◽  
Dose Response Relationship

scholarly journals Occupational Exposure to Diesel Motor Exhaust and Lung Cancer: A Dose-Response Relationship Hidden by Asbestos Exposure Adjustment? The ICARE Study

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Mireille Matrat ◽  
Florence Guida ◽  
Sylvie Cénée ◽  
Joelle Févotte ◽  
Matthieu Carton ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Occupational Exposure ◽  
Dose Response ◽  
Asbestos Exposure ◽  
Large Population ◽  
Population Based ◽  
Cumulative Exposure ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Motor Exhaust

Background. In a French large population-based case-control study we investigated the dose-response relationship between lung cancer and occupational exposure to diesel motor exhaust (DME), taking into account asbestos exposure.Methods. Exposure to DME was assessed by questionnaire. Asbestos was taken into account through a global indicator of exposure to occupational carcinogens or by a specific JEM.Results. We found a crude dose response relationship with most of the indicators of DME exposure, including with the cumulative exposure index. All results were affected by adjustment for asbestos exposure. The dose response relationships between DME and lung cancer were observed among subjects never exposed to asbestos.Conclusions. Exposure to DME and to asbestos is frequently found among the same subjects, which may explain why dose-response relationships in previous studies that adjusted for asbestos exposure were inconsistent.

scholarly journals Dose-response Relationship Between Sleep Duration and Human Psychomotor Vigilance and Subjective Alertness

SLEEP ◽  
1999 ◽  
Vol 22 (2) ◽  
pp. 171-179 ◽  
Author(s):  
Megan E. Jewett ◽  
Derk-Jan Dijk ◽  
Richard E. Kronauer ◽  
David F. Dinges
Keyword(s):  
Sleep Duration ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Subjective Alertness ◽  
Psychomotor Vigilance

scholarly journals The effect of menopausal hormone therapy on gastrointestinal cancer risk and mortality in South Korea: a population-based cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ji Hyung Nam ◽  
Sung-In Jang ◽  
Hyun Soo Park ◽  
Jae Hak Kim ◽  
Jun Kyu Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hormone Therapy ◽  
Dose Response ◽  
Population Based ◽  
Menopausal Hormone Therapy ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Gi Cancer ◽  
Kaplan Meier ◽  
Gi Cancers

Abstract Background The effect of menopausal hormone therapy (MHT) on gastrointestinal (GI) cancers is controversial, and no research has been conducted in the East. This study investigates the association between MHT and GI cancer risks in South Korea. Methods A prescription-based cohort study was conducted using the NHIS Sample Cohort (2002–2013) of Korea. We used 1:5 propensity score matching, and 22,577 MHT users and 111,113 non-users were selected. Kaplan–Meier survival curves with log-rank tests were used. Cox proportional hazard models were used to estimate hazard ratios (HR) with 95% confidence intervals (CI). Landmark analysis was used to determine dose–response relationship. Results The median follow-up was 79.6 of months. Kaplan–Meier survival curve showed less frequent GI cancer diagnoses in MHT users compared to non-users (0.13 vs. 0.16 per 100,000 person-years). Menopausal hormone therapy was associated with decreased incidence of GI cancer (HR = 0.809, 95%CI = 0.691–0.946) and colorectal cancer (CRC) (HR = 0.757, 95%CI = 0.577–0.995). Gastric cancer (GC) incidence showed marginal significance (HR = 0.787, 95%CI = 0.605–1.023). The mortality from GI cancer was lower in MHT users than in non-users (HR = 0.737, 95%CI = 0.547–0.993). The relationship between MHT and GI cancer was stronger with increasing MHT dose in terms of both incidence (Ptrend = 0.0002) and mortality (Ptrend = 0.0064). Conclusions The association between MHT use and reduced risks of GI cancers was attributed to CRC and GC and showed a dose–response relationship in a population-based cohort study.

scholarly journals A Second Population-Based Cohort Study in Cameroon Confirms the Temporal Relationship Between Onchocerciasis and Epilepsy

2020 ◽  
Vol 7 (6) ◽  
Author(s):  
Cédric B Chesnais ◽  
Charlotte Bizet ◽  
Jérémy T Campillo ◽  
Wepnyu Y Njamnshi ◽  
Jean Bopda ◽  
...  
Keyword(s):  
Cohort Study ◽  
Dose Response ◽  
Temporal Relationship ◽  
Population Based ◽  
Onchocerca Volvulus ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Relative Risks ◽  
Acquired Epilepsy

Abstract To confirm our earlier evidence of a temporal and dose–response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose Onchocerca volvulus microfilarial density (Ov-MFD) was measured in 1992–1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992–1994, the relative risks of acquiring epilepsy were 0.96, 2.76, 3.67, and 11.87 in subjects with initial Ov-MFD of 1–7, 8–70, 71–200, and > 200 microfilariae per skin snip, respectively. This study further demonstrates reproducibility using the Bradford Hill’s criteria for causality.

scholarly journals Body mass index and its dose-response relationship with the incidence and risk of tuberculosis, a population-based cohort study

2020 ◽  
Author(s):  
Jinou Chen ◽  
Shun Zha ◽  
Jinglong Hou ◽  
Kunyun Lu ◽  
Yubing Qiu ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Dose Response ◽  
Population Based ◽  
Normal Weight ◽  
The Body ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Tuberculosis Incidence ◽  
Tuberculosis Risk

Abstract Background Many pieces of evidence presented the body mass index (BMI) was inversely associated with tuberculosis (TB). BMI was radically changed during the past decades in China. The aim of the study was to evaluate the contemporary relationship between BMI and tuberculosis incident. Methods A population-based prospective cohort included 26 022 community participants was conducted. Three rounds of tuberculosis screening were implemented between June 2013 and December 2015. The main exposure was defined as baseline BMI, and was categorized into 3 levels: underweight (< 18.5 kg/m2), normal (18.5 to 24.0 kg/m2), overweight or obese (≥ 24.0 kg/m2). The active tuberculosis incident in the second or third round screening was the study outcome. The dose-response relationship between BMI and tuberculosis incidence as well as tuberculosis risk were analyzed. Results During the followed up of 2.25 years, 43 cases developed tuberculosis in 44 574.4 person-years. The log-linear dose-response relationship between BMI and tuberculosis incidence was fitted (adjusted R2 = 0.95). In multivariable Cox proportional regression, overweight and obese was associated with a lower risk of incident tuberculosis compared with normal weight (adjusted hazard ratio [aHR], 0.34; 95% confidence interval [CI] 0.14–0.82, p < 0.01), the inverse dose-response association between BMI and tuberculosis risk was characterized by restricted cubic spline. In subgroups analysis, the risk of tuberculosis reduced 78% in overweight or obese (aHR, 0.22; 95% CI 0.05–0.97, p = 0.05) and 64% (aHR, 0.36; 95% CI 0.12-1.00, p = 0.05) compared with normal weight among female and elderly. Conclusion Our study revealed that high BMI was a protective factor in tuberculosis development. Precise dose-response relationship between BMI and the incident tuberculosis, as well as the risk of tuberculosis progression in contemporary Chinese adulthood, will benefit to disease control policy.

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