Dose–response relationship between inorganic arsenic exposure and lung cancer among arseniasis area residents with low methylation capacity: A population-based cohort study

2016 ◽  
Vol 61 ◽  
pp. S154
Author(s):  
P.J. Liao ◽  
K.H. Hsu
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Dose Response ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Population Based ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Methylation Capacity

scholarly journals Occupational Exposure to Diesel Motor Exhaust and Lung Cancer: A Dose-Response Relationship Hidden by Asbestos Exposure Adjustment? The ICARE Study

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Mireille Matrat ◽  
Florence Guida ◽  
Sylvie Cénée ◽  
Joelle Févotte ◽  
Matthieu Carton ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Occupational Exposure ◽  
Dose Response ◽  
Asbestos Exposure ◽  
Large Population ◽  
Population Based ◽  
Cumulative Exposure ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Motor Exhaust

Background. In a French large population-based case-control study we investigated the dose-response relationship between lung cancer and occupational exposure to diesel motor exhaust (DME), taking into account asbestos exposure.Methods. Exposure to DME was assessed by questionnaire. Asbestos was taken into account through a global indicator of exposure to occupational carcinogens or by a specific JEM.Results. We found a crude dose response relationship with most of the indicators of DME exposure, including with the cumulative exposure index. All results were affected by adjustment for asbestos exposure. The dose response relationships between DME and lung cancer were observed among subjects never exposed to asbestos.Conclusions. Exposure to DME and to asbestos is frequently found among the same subjects, which may explain why dose-response relationships in previous studies that adjusted for asbestos exposure were inconsistent.

scholarly journals The effect of menopausal hormone therapy on gastrointestinal cancer risk and mortality in South Korea: a population-based cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ji Hyung Nam ◽  
Sung-In Jang ◽  
Hyun Soo Park ◽  
Jae Hak Kim ◽  
Jun Kyu Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hormone Therapy ◽  
Dose Response ◽  
Population Based ◽  
Menopausal Hormone Therapy ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Gi Cancer ◽  
Kaplan Meier ◽  
Gi Cancers

Abstract Background The effect of menopausal hormone therapy (MHT) on gastrointestinal (GI) cancers is controversial, and no research has been conducted in the East. This study investigates the association between MHT and GI cancer risks in South Korea. Methods A prescription-based cohort study was conducted using the NHIS Sample Cohort (2002–2013) of Korea. We used 1:5 propensity score matching, and 22,577 MHT users and 111,113 non-users were selected. Kaplan–Meier survival curves with log-rank tests were used. Cox proportional hazard models were used to estimate hazard ratios (HR) with 95% confidence intervals (CI). Landmark analysis was used to determine dose–response relationship. Results The median follow-up was 79.6 of months. Kaplan–Meier survival curve showed less frequent GI cancer diagnoses in MHT users compared to non-users (0.13 vs. 0.16 per 100,000 person-years). Menopausal hormone therapy was associated with decreased incidence of GI cancer (HR = 0.809, 95%CI = 0.691–0.946) and colorectal cancer (CRC) (HR = 0.757, 95%CI = 0.577–0.995). Gastric cancer (GC) incidence showed marginal significance (HR = 0.787, 95%CI = 0.605–1.023). The mortality from GI cancer was lower in MHT users than in non-users (HR = 0.737, 95%CI = 0.547–0.993). The relationship between MHT and GI cancer was stronger with increasing MHT dose in terms of both incidence (Ptrend = 0.0002) and mortality (Ptrend = 0.0064). Conclusions The association between MHT use and reduced risks of GI cancers was attributed to CRC and GC and showed a dose–response relationship in a population-based cohort study.

scholarly journals A Second Population-Based Cohort Study in Cameroon Confirms the Temporal Relationship Between Onchocerciasis and Epilepsy

2020 ◽  
Vol 7 (6) ◽  
Author(s):  
Cédric B Chesnais ◽  
Charlotte Bizet ◽  
Jérémy T Campillo ◽  
Wepnyu Y Njamnshi ◽  
Jean Bopda ◽  
...  
Keyword(s):  
Cohort Study ◽  
Dose Response ◽  
Temporal Relationship ◽  
Population Based ◽  
Onchocerca Volvulus ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Relative Risks ◽  
Acquired Epilepsy

Abstract To confirm our earlier evidence of a temporal and dose–response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose Onchocerca volvulus microfilarial density (Ov-MFD) was measured in 1992–1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992–1994, the relative risks of acquiring epilepsy were 0.96, 2.76, 3.67, and 11.87 in subjects with initial Ov-MFD of 1–7, 8–70, 71–200, and > 200 microfilariae per skin snip, respectively. This study further demonstrates reproducibility using the Bradford Hill’s criteria for causality.

scholarly journals There is no Dose-response Relationship between Allogeneic Blood Transfusion and Healthcare-associated Infection: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Yu Lv ◽  
Qian Xiang ◽  
Jia Lin ◽  
Ying Zong Jin ◽  
Ying Fang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Cohort Study ◽  
Dose Response ◽  
Retrospective Cohort ◽  
Response Relationship ◽  
Spline Regression ◽  
Blood Products ◽  
Healthcare Associated Infection ◽  
Dose Response Relationship ◽  
Healthcare Associated

Abstract BackgroundThe association between allogeneic blood transfusion (ABT) and healthcare-associated infection (HAI) is considered dose-dependent. However, this association may be confounded by transfusion duration, as prolonged hospitalization stay increases the risk of HAI. Also, it is not clear whether specific blood products have different dose-response risks.MethodsIn this retrospective cohort study, a logistic regression was used to identify confounding factors, and the association between specific blood products and HAI were analyzed. Then Cox regression and restricted cubic spline regression was used to visualize the hazard of HAI per transfusion product.ResultsOf 215338 inpatients observed, 4.16% were transfused with a single component blood product. With regard to these transfused patients, 480 patients (5.36 %) developed a HAI during their hospitalization stay. Logistic regression showed that red blood cells (RBCs) transfusion, platelets transfusion and fresh-frozen plasmas (FFPs) transfusion were risk factors for HAI [odds ratio (OR) 1.893, 95% confidence interval (CI) 1.656–2.163; OR 8.903, 95% CI 6.646–11.926 and OR 1.494, 95% CI 1.146–1.949, respectively]. However, restricted cubic spline regression analysis showed that there was no statistically dose-response relationship between different transfusion products and the onset of HAI.ConclusionsRBCs transfusion, platelets transfusion and FFPs transfusion were associated with HAI, but there was no dose-response relationship between them.

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