Anatomic and Functional Outcome Following Distal Shunt and Tunneling for Treatment İschemic Priapism: A Single-Center Experience

AbstractPlatelet activation has been postulated to be involved in the pathogenesis of delayed cerebral ischemia (DCI) and cerebral vasospasm (CVS) after aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to investigate potentially beneficial effects of antiplatelet therapy (APT) on angiographic CVS, DCI-related infarction and functional outcome in endovascularly treated aSAH patients. Retrospective single-center analysis of aSAH patients treated by endovascular aneurysm obliteration. Based on the post-interventional medical regime, patients were assigned to either an APT group or a control group not receiving APT. A subgroup analysis separately investigated those APT patients with aspirin monotherapy (MAPT) and those receiving dual treatment (aspirin plus clopidogrel, DAPT). Clinical and radiological characteristics were compared between groups. Possible predictors for angiographic CVS, DCI-related infarction, and an unfavorable functional outcome (modified Rankin scale ≥ 3) were analyzed. Of 160 patients, 85 (53%) had received APT (n = 29 MAPT, n = 56 DAPT). APT was independently associated with a lower incidence of an unfavorable functional outcome (OR 0.40 [0.19–0.87], P = 0.021) after 3 months. APT did not reduce the incidence of angiographic CVS or DCI-related infarction. The pattern of angiographic CVS or DCI-related infarction as well as the rate of intracranial hemorrhage did not differ between groups. However, the lesion volume of DCI-related infarctions was significantly reduced in the DAPT subgroup (P = 0.011). Post-interventional APT in endovascularly treated aSAH patients is associated with better functional outcome at 3 months. The beneficial effect of APT might be mediated by reduction of the size of DCI-related infarctions.

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Abstract 65: Intrathecal Nicardipine for Cerebral Vasospasm Post Subarachnoid Hemorrhage - A Single Center Experience

Stroke ◽

10.1161/str.51.suppl_1.65 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Ofer Sadan ◽

Chen Feng ◽

David T Pearce ◽

Jacqueline Kraft ◽

Cederic Pimentel ◽

...

Keyword(s):

Subarachnoid Hemorrhage ◽

Cerebral Ischemia ◽

Functional Outcome ◽

Effective Treatment ◽

Cerebral Vasospasm ◽

Delayed Cerebral Ischemia ◽

Low Grade ◽

Single Center ◽

Duration Of Treatment ◽

Single Center Experience

Introduction: Cerebral vasospasm leading to delayed cerebral ischemia (DCI) is one of the most significant factors impacting functional outcome in patients diagnosed with non-traumatic subarachnoid hemorrhage (SAH). Effective treatment in this setting is lacking. We now report a single center retrospective cohort experience with intrathecal (IT) Nicardipine for this indication. Methods: All patients discharged between 2013-2017 diagnosed with non-traumatic SAH, either aneurysmal or idiopathic, were included in the analysis. Demographics, risk factors, clinical courses, radiological DCI, and functional outcomes were analyzed. Results: 1,085 patients were admitted with aneurysmal (n=796) or idiopathic (n=289) SAH. The mean age was 54.5±14.1 and 67.7% were women. Low grade hemorrhage (WFNS 1) was found in 42.4%, medium (WFNS 2-3) in 26.9%, and high grade (WFNS 4-5) in 30.7%. Cerebral vasospasm was diagnosed in 36.6% of the patients, and 85.4% of those received IT Nicardipine (n=339). Only 8.4% of all patients required angiography to treat vasospasm. TCD data was available for 159 patients who received IT Nicardipine. Treatment reduced mean velocities in all arteries within one day by 15.4% on average (p<0.01). This reduction was sustained for the duration of treatment. Nineteen patients (1.8%) suffered from bacterial ventriculitis, and no statistically significant correlation was noted between IT treatment and infection (OR 1.06 95%CI[0.42-2.7]). The incidence of radiological DCI, identified by blinded assement of imaging, was 9.4% and clinical DCI was 5.7%. In this cohort, 65.5% had a favorable functional outcome (mRS≤2) at 90 days. Conclusions: In a retrospective analysis, off-label IT Nicardipine is a safe and potentially effective treatment for cerebral vasospasm and prevention of the subsequent cerebral ischemia. Being the largest of its kind, this cohort could serve as a baseline for future clinical trial designs assessing IT Nicardipine safety and efficacy in a prospective, controlled fashion.

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E-053 Peri-procedure anemia is associated with poor functional outcome after mechanical thrombectomy for acute ischemic stroke: single center experience

10.1136/neurintsurg-2020-snis.89 ◽

2020 ◽

Author(s):

H Carvalho ◽

A Wessell ◽

G Cannarsa ◽

T Miller ◽

D Gandhi ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Functional Outcome ◽

Mechanical Thrombectomy ◽

Single Center ◽

Poor Functional Outcome ◽

Single Center Experience

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Functional outcome after recanalization therapy for basilar artery occlusion: A single center experience

Journal of the Neurological Sciences ◽

10.1016/j.jns.2021.118682 ◽

2021 ◽

Vol 429 ◽

pp. 118682

Author(s):

Ivona Šamle ◽

Svjetlana Šupe ◽

Josip Ljevak ◽

Marko Radoš ◽

Danilo Gardijan ◽

...

Keyword(s):

Functional Outcome ◽

Basilar Artery ◽

Artery Occlusion ◽

Basilar Artery Occlusion ◽

Single Center ◽

Single Center Experience

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Treatment and functional outcome of patients with cystoid macular edema: a single-center experience

Clinical Rheumatology ◽

10.1007/s10067-014-2694-z ◽

2014 ◽

Vol 34 (4) ◽

pp. 791-794 ◽

Cited By ~ 1

Author(s):

Mara Taraborelli ◽

Ilaria Cavazzana ◽

Micaela Fredi ◽

Paolo Airò ◽

Giuseppe Nascimbeni ◽

...

Keyword(s):

Macular Edema ◽

Functional Outcome ◽

Cystoid Macular Edema ◽

Single Center ◽

Single Center Experience

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Long-Term Functional Outcome of Telestroke Patients Treated Under Drip-and-Stay Paradigm Compared with Patients Treated in a Comprehensive Stroke Center: A Single Center Experience

Telemedicine Journal and e-Health ◽

10.1089/tmj.2018.0137 ◽

2019 ◽

Vol 25 (8) ◽

pp. 724-729 ◽

Cited By ~ 11

Author(s):

Eyad Almallouhi ◽

Christine A. Holmstedt ◽

Jillian Harvey ◽

Christopher Reardon ◽

Waldo R. Guerrero ◽

...

Keyword(s):

Functional Outcome ◽

Single Center ◽

Single Center Experience ◽

Comprehensive Stroke Center ◽

Stroke Center

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Long-term functional outcome of sacrococcygeal teratoma after resection in neonates and infants: a single-center experience

Pediatric Surgery International ◽

10.1007/s00383-020-04752-7 ◽

2020 ◽

Vol 36 (11) ◽

pp. 1327-1332

Author(s):

Kazunori Masahata ◽

Chihiro Ichikawa ◽

Katsutoshi Makino ◽

Takatoshi Abe ◽

Kiyokazu Kim ◽

...

Keyword(s):

Functional Outcome ◽

Sacrococcygeal Teratoma ◽

Single Center ◽

Single Center Experience ◽

Neonates And Infants

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Functional results and survivorship after medial unicompartmental knee arthroplasty: a single center experience from Saudi Arabia

Annals of Saudi Medicine ◽

10.5144/0256-4947.2021.299 ◽

2021 ◽

Vol 41 (5) ◽

pp. 299-306

Author(s):

Ammar Qutub ◽

Amjad Ghandurah ◽

Adel Alzahrani ◽

Ahmed Alghamdi ◽

Talal M. Bakhsh

Keyword(s):

Saudi Arabia ◽

Survival Rate ◽

Functional Outcome ◽

Knee Arthroplasty ◽

Unicompartmental Knee Arthroplasty ◽

Tertiary Care ◽

Medial Compartment ◽

Single Center ◽

Single Center Experience ◽

Medial Unicompartmental Knee Arthroplasty

BACKGROUND: Isolated involvement of the medial compartment of the knee in degenerative disease is encountered in about 25% of patients with gonarthrosis. We aim to show that in a well-selected group of such patients, medial unicompartmental knee arthroplasty (UKA) is a good option. OBJECTIVES: Review the functional outcomes of patients undergoing UKA and determine the long-term survivorship of the implants and complications of the procedure. DESIGN: Analytical retrospective chart review. SETTING: Academic tertiary care medical center and tertiary care private hospital in the western region of Saudi Arabia. PATIENTS AND METHODS: We selected patients who underwent medial UKAs by the same surgeon between December 1988 and December 2009. The life table approach and the Kaplan-Meier statistical method were used to estimate the survival rate (5–30 years) with revision as the endpoint. Functional outcome scores were determined according to the Knee Society Clinical Rating System. MAIN OUTCOME MEASURES: Change in performance scores for pain, walking, and range of movement. Survivorship of the implants with removal of the implant as the endpoint; post-operative complications. SAMPLE SIZE: 218 implants on 142 patients. RESULTS: The survival rate for UKA was 94.7% at 10 years (95% CI 0.906–0.970), 80.9% at 20 years (95%CI 0.724–0.871), and at 30 years it was 77.8% (95%CI 0.669–0.855) of the total knee arthropathies. The average grand total functional score increased from 61 (maximum 200) at 0 months to above 150 at ≥6 months. CONCLUSION: UKA is a good option for isolated medial compartment gonarthrosis with excellent functional outcome and good survivorship in selected patients. LIMITATION: Single center experience, retrospective. We lost 6.0% of patients during follow-up. CONFLICT OF INTEREST: None.

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