Disease criteria of systemic lupus erythematosus (SLE); the potential role of non-criteria autoantibodies

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with various clinical manifestations, including, rarely, a form of interstitial cystitis (lupus cystitis, LC). LC can be asymptomatic and usually has discrete symptoms that improve with conventional therapies available for SLE and/or typical interstitial cystitis. A very severe and refractory form is rarely described. In this study, we present four patients with SLE and a very severe form of noninfectious cystitis refractory to the different forms of treatment described. The clinical descriptions of the cases, demographic factors, manifestations associated with SLE, and clinical and paraclinical manifestations related to cystitis, treatments, and outcomes are provided. A proposal for the pathogenesis of this condition is based on the common findings of these patients, including the fact that three were in SLE remission and all four receiving rituximab as induction and/or maintenance therapy.

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Role of Vitamin D in Systemic Lupus Erythematosus

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2014.119 ◽

2014 ◽

Vol 2 (4) ◽

pp. 662-667 ◽

Cited By ~ 1

Author(s):

Rada Miskovic ◽

Aleksandra Plavsic ◽

Jasna Bolpacic ◽

Sanvila Raskovic ◽

Mirjana Bogic

Keyword(s):

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Lupus Erythematosus ◽

Animal Studies ◽

Potential Role ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Systemic Lupus

Vitamin D is a steroid hormone that in addition to its well known role in the metabolism of calcium and phosphorus exerts immunoregulatory properties. Data from animal studies and from prospective clinical trials on patients with rheumatoid arthritis, multiple sclerosis and type 1 diabetes point to the potential role of vitamin D as important environmental factor in the development of autoimmune diseases. Such role of vitamin D in systemic lupus erythematosus (SLE) has not yet been sufficiently studied. This review shows the sources, metabolism and mechanism of action of vitamin D, its effect on the cells of the immune system, prevalence and causes of vitamin D deficiency in patients with SLE, the link between vitamin D status and disease activity as well as recommendations for vitamin D supplementation.

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The potential role of SLE-key test in identifying patients with Systemic Lupus Erythematosus: Results from a prospective, real-world experience

European Journal of Internal Medicine ◽

10.1016/j.ejim.2019.07.026 ◽

2019 ◽

Vol 68 ◽

pp. e12-e14

Author(s):

Massimo Radin ◽

Savino Sciascia ◽

Irene Cecchi ◽

Giulio Mengozzi ◽

Dario Roccatello

Keyword(s):

Systemic Lupus Erythematosus ◽

Real World ◽

Lupus Erythematosus ◽

Potential Role ◽

Systemic Lupus

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The potential role of CD4+CD52lo T-cell populations in systemic lupus erythematosus

Clinical Immunology ◽

10.1016/j.clim.2019.01.007 ◽

2019 ◽

Vol 200 ◽

pp. 35-36

Author(s):

Kunihiro Ichinose ◽

Masataka Umeda ◽

Tomohiro Koga ◽

Atsushi Kawakami

Keyword(s):

Systemic Lupus Erythematosus ◽

T Cell ◽

Lupus Erythematosus ◽

Potential Role ◽

Cell Populations ◽

Systemic Lupus

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SAT0163 Defective autophagy in T lymphocytes from patients with systemic lupus erythematosus: Potential role of anti-lymphocyte autoantibodies

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2012-eular.3110 ◽

2013 ◽

Vol 71 (Suppl 3) ◽

pp. 526.4-527

Author(s):

C. Alessandri ◽

M. Pierdominici ◽

F. Conti ◽

S. Truglia ◽

C. Barbati ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

T Lymphocytes ◽

Lupus Erythematosus ◽

Potential Role ◽

Systemic Lupus

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Absence of pathogenic Short Tandem Repeat expansions in Systemic Lupus Erythematosus disease-associated genes

10.1101/729467 ◽

2019 ◽

Author(s):

Audrey Lee ◽

Vicky Cho ◽

T. Daniel Andrews

Keyword(s):

Systemic Lupus Erythematosus ◽

Tandem Repeat ◽

Huntington Disease ◽

Lupus Erythematosus ◽

Potential Role ◽

Neurological Diseases ◽

Systemic Lupus ◽

Computational Tools ◽

Short Tandem

AbstractShort tandem repeat (STR) expansions have been shown to be pathogenic in human neurological diseases, such as Huntington disease. Yet, the potential role of STRs in non-neurological diseases has yet to be fully investigated. In this study, the potential role of STR expansions in the pathogenesis of systemic lupus erythematosus (SLE) was investigated using patient genomic data and two computational tools, HipSTR and exSTRa. The length variability of STRs in 76 SLE-associated genes was compared using exome data from 271 SLE affected individuals and 158 of their unaffected relatives. We conclude that no large STR expansions associated with SLE were present in these affected individuals within the 76 genes investigated. Lack of evidence does not negate a pathogenic role for STR expansions in SLE, yet given the number of individuals included in this study, we expect that this is not a common source of pathogenesis in SLE.Significance statementThe increasing availability and decreasing cost of sequencing genomes lends itself to computational analysis, extracting information to aid diagnosis, guide treatment or discover disease mechanisms and new treatments. Computational tools have been developed to look for various types of mutations, including short tandem repeats (STRs), which has been shown to cause diseases such as Huntington disease. Limited research on the possible role of STR expansions in systemic lupus erythematosus (SLE) has been done. Here we use computational tools to compare the length of STRs in 76 SLE-associated genes in patients and their unaffected relatives. Our results did not identify any large STR expansions associated with SLE, and further research is required to gain a better understanding of this complex disease.

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Entheseal involvement in systemic lupus erythematosus: are we missing something?

Lupus ◽

10.1177/0961203316662723 ◽

2016 ◽

Vol 26 (3) ◽

pp. 320-328 ◽

Cited By ~ 5

Author(s):

A Di Matteo ◽

I Satulu ◽

M Di Carlo ◽

V Lato ◽

E Filippucci ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Potential Role ◽

Power Doppler ◽

Case Series ◽

Systemic Lupus ◽

Grey Scale ◽

First Time ◽

Dose Prednisone

Background Musculoskeletal involvement is extremely common in patients with systemic lupus erythematosus (SLE). Continuing the research initiated in patients with inflammatory arthritis, recent studies have shown the potential role of musculoskeletal ultrasound (MSUS) in the evaluation of clinical and subclinical lupus synovitis. The inflammatory process in SLE is traditionally considered to be localized at synovial tissue areas while enthesis is not included among the possible targets of the disease. Patients and methods Entheses included in the Glasgow Ultrasound Enthesitis Scoring System were scanned in a cohort of 20 SLE patients serving as disease controls in an MSUS study aimed at assessing enthesitis in patients with psoriatic arthritis. We describe in detail four cases with unexpected and unequivocal expressions of MSUS enthesitis according to the OMERACT definition. Three out of four patients had no predisposing factors for enthesopathy. Case no. 2 was treated with a variable-dose prednisone regimen. Results In the four cases MSUS examination revealed relevant grey-scale and power Doppler abnormalities at the entheseal level, most commonly at the distal insertion of the patellar tendon. Signs of clinical enthesitis were detected in only one patient. Conclusions This case series shows for the first time the presence of clearly evident MSUS findings indicative of enthesitis in four out of 20 SLE patients (20%), raising the hypothesis that enthesis could be a missing target in the clinical evaluation of SLE patients. Our case series justifies further investigations for a better evaluation of the prevalence, characteristics and clinical relevance of entheseal involvement in SLE.

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