scholarly journals Insights on the molecular mechanism of anti-inflammatory effect of formula from Islamic traditional medicine: An in-silico study

2019 ◽  
Vol 9 (4) ◽  
pp. 353-363 ◽  
Author(s):  
Abdullah A. Elgazar ◽  
Hamada Ramadan Knany ◽  
Mohammed Soliman Ali
Keyword(s):  
Traditional Medicine ◽  
Molecular Mechanism ◽  
In Silico ◽  
In Silico Study ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Synthesis of novel 2-pyrazoline analogues with potent anti-inflammatory effect mediated by inhibition of phospholipase A2: Crystallographic, in silico docking and QSAR analysis

2017 ◽  
Vol 27 (16) ◽  
pp. 3806-3811 ◽  
Author(s):  
Devirammanahalli Mahadevaswamy Lokeshwari ◽  
Dileep Kumar Achutha ◽  
Bharath Srinivasan ◽  
Naveen Shivalingegowda ◽  
Lokanath Neratur Krishnappagowda ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
In Silico ◽  
Qsar Analysis ◽  
In Silico Docking ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-inflammatory effect of herbal traditional medicine extract on molecular regulation in allergic asthma

2021 ◽  
Vol 5 (01) ◽  
pp. 148-156
Author(s):  
Xiaopeng Sun ◽  
Entezar Mehrabi Nasab ◽  
Seyyede Masoume Athari ◽  
Seyyed Shamsadin Athari
Keyword(s):  
Traditional Medicine ◽  
Allergic Asthma ◽  
Molecular Regulation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Molecular Mechanism of Anti-Inflammatory Activities of a Novel Sulfated Galactofucan from Saccharina japonica

Marine Drugs ◽  
2021 ◽  
Vol 19 (8) ◽  
pp. 430
Author(s):  
Xiaodan Chen ◽  
Liying Ni ◽  
Xiaoting Fu ◽  
Lei Wang ◽  
Delin Duan ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Death Rate ◽  
Food Industry ◽  
Brown Seaweed ◽  
Saccharina Japonica ◽  
Oxygen Species ◽  
Cell Death Rate ◽  
The World ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Seaweed of Saccharina japonica is the most abundantly cultured brown seaweed in the world, and has been consumed in the food industry due to its nutrition and the unique properties of its polysaccharides. In this study, fucoidan (LJNF3), purified from S. japonica, was found to be a novel sulfated galactofucan, with the monosaccharide of only fucose and galactose in a ratio of 79.22:20.78, and with an 11.36% content of sulfate groups. NMR spectroscopy showed that LJNF3 consists of (1→3)-α-l-fucopyranosyl-4-SO3 residues and (1→6)-β-d-galactopyranose units. The molecular mechanism of the anti-inflammatory effect in RAW264.7 demonstrated that LJNF3 reduced the production of nitric oxide (NO), and down-regulated the expression of MAPK (including p38, ENK and JNK) and NF-κB (including p65 and IKKα/IKKβ) signaling pathways. In a zebrafish experiment assay, LJNF3 showed a significantly protective effect, by reducing the cell death rate, inhibiting NO to 59.43%, and decreasing about 40% of reactive oxygen species. This study indicated that LJNF3, which only consisted of fucose and galactose, had the potential to be developed in the biomedical, food and cosmetic industries.

scholarly journals A3Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect:In VivoStudies and Molecular Mechanism of Action

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Shira Cohen ◽  
Faina Barer ◽  
Sara Bar-Yehuda ◽  
Adriaan P. IJzerman ◽  
Kenneth A. Jacobson ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Mechanism Of Action ◽  
Mononuclear Cells ◽  
White Blood Cells ◽  
Drug Candidate ◽  
Allosteric Modulator ◽  
Allosteric Modulators ◽  
Molecular Mechanism Of Action ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The A3adenosine receptor (A3AR) is overexpressed in inflammatory cells and in the peripheral blood mononuclear cells of individuals with inflammatory conditions. Agonists to the A3AR are known to induce specific anti-inflammatory effects upon chronic treatment. LUF6000 is an allosteric compound known to modulate the A3AR and render the endogenous ligand adenosine to bind to the receptor with higher affinity. The advantage of allosteric modulators is their capability to target specifically areas where adenosine levels are increased such as inflammatory and tumor sites, whereas normal body cells and tissues are refractory to the allosteric modulators due to low adenosine levels. LUF6000 administration induced anti-inflammatory effect in 3 experimental animal models of rat adjuvant induced arthritis, monoiodoacetate induced osteoarthritis, and concanavalin A induced liver inflammation in mice. The molecular mechanism of action points to deregulation of signaling proteins including PI3K, IKK, IκB, Jak-2, and STAT-1, resulting in decreased levels of NF-κB, known to mediate inflammatory effects. Moreover, LUF6000 induced a slight stimulatory effect on the number of normal white blood cells and neutrophils. The anti-inflammatory effect of LUF6000, mechanism of action, and the differential effects on inflammatory and normal cells position this allosteric modulator as an attractive and unique drug candidate.

Activity Anti-Inflammatory and in silico Study of New Thiazolidinedione Derivatives

2014 ◽  
Vol 4 (14) ◽  
pp. 1739-1752
Author(s):  
Laudelina Magalhães ◽  
Iane Alves ◽  
Everaldo Santos ◽  
Vinícius Silva ◽  
Luiz Silva ◽  
...  
Keyword(s):  
In Silico ◽  
In Silico Study ◽  
Anti Inflammatory

scholarly journals In-silico Study of Molecular Properties, Bioactivity and Toxicity of 2-(Substituted benzylidene)succinic acids and Some Selected Anti-Inflammatory Drugs

2020 ◽  
pp. 353-359
Author(s):  
Madhavi Kuchana ◽  
Maneesha Pulavarthi ◽  
Sasikala Potthuri ◽  
Vyshnavi Manduri ◽  
Vijaya Durga Jaggarapu
Keyword(s):  
Ion Channel ◽  
Succinic Acid ◽  
Nuclear Receptor ◽  
In Silico ◽  
Enzyme Inhibitor ◽  
Molecular Properties ◽  
Renin Inhibitors ◽  
In Silico Study ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Succinic acid and its derivatives have many important uses, especially in pharmaceutical and polymer industry. The 2-(substituted benzylidene)succinic acids also known as substituted phenylitaconic acids are utilized in the synthesis of some lignans, lignanamides and renin inhibitors.  In view of this, the present in-silico study aimed to calculate the molecular properties, bioactivity score and toxicity of several benzylidenesuccinic acids as well as some selected anti-inflammatory drugs by computational methods.  The study revealed that all the compounds obeyed Lipinski’s rule of five, indicating drug likeness properties. The bioactivity data revealed that the 2-(substituted benzylidene)succinic acids were active as Nuclear receptor ligands, Enzyme inhibitors, GPCR ligands and Ion channel modulators. Among all, 2-(3,5-di-tert-butyl-4-hydroxybenzylidene)succinic acid was predicted as non-toxic with better in-silico molecular properties and bioactivity as Nuclear receptor ligand, Enzyme inhibitor, GPCR ligand, Ion channel modulator and Protease inhibitor compared to some of the predicted anti-inflammatory drugs.

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