Seleno-l-methionine and l-ascorbic acid differentiate the biological activity of doxorubicin and its metal complexes as a new anticancer drugs candidate

Twenty-five novel 2,4,6-trisubstituted triazines were synthesized and biologically evaluated. Most of the compounds synthesized showed good antiproliferative activity against HCT-116 and MCF-7. Compounds B18 and B19 showed the best antiproliferative activity. Further study showed B18 and B19 inhibited four phosphoinositide 3-kinase isoforms and mammalian target of rapamycin with good potency. These results demonstrate that 2,4,6-trisubstituted triazines are potentially useful phosphoinositide 3-kinase inhibitors for the development of new anticancer drugs.

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Bioactive Olivacine Derivatives—Potential Application in Cancer Therapy

Biology ◽

10.3390/biology10060564 ◽

2021 ◽

Vol 10 (6) ◽

pp. 564

Author(s):

Beata Tylińska ◽

Benita Wiatrak

Keyword(s):

Clinical Trials ◽

Biological Activity ◽

Growth Factors ◽

Anticancer Drugs ◽

Inhibition Of Growth ◽

Structure Activity ◽

Sar Analysis ◽

New Anticancer Drugs

Olivacine and its derivatives are characterized by multidirectional biological activity. Noteworthy is their antiproliferative effect related to various mechanisms, such as inhibition of growth factors, enzymes, kinases and others. The activity of these compounds was tested on cell lines of various tumors. In most publications, the most active olivacine derivatives exceeded the effects of doxorubicin (a commonly used anticancer drug), so in the future, they may become the main new anticancer drugs. In this publication, we present the groups of the most active olivacine derivatives obtained. In this work, the in vitro and in vivo activity of olivacine and its most active derivatives are presented. We describe olivacine derivatives that have been in clinical trials. We conducted a structure–activity relationship (SAR) analysis that may be used to obtain new olivacine derivatives with better properties than the available anticancer drugs.

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Synthesis, characterization and biological activity studies of mixed paracetamol- ascorbic acid metal complexes

Journal of Applied Sciences and Environmental Management ◽

10.4314/jasem.v20i4.32 ◽

2017 ◽

Vol 20 (4) ◽

pp. 1157

Author(s):

HF Babamale ◽

A Lawal ◽

OA Rajee ◽

EA Oloyede

Keyword(s):

Ascorbic Acid ◽

Biological Activity ◽

Metal Complexes

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New Anticancer Drugs

10.1007/978-3-642-81392-4 ◽

1980 ◽

Cited By ~ 1

Keyword(s):

Anticancer Drugs ◽

New Anticancer Drugs

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SYNTHESIS AND CHARACTERIZATION AND STUDY OF THE BIOLOGICAL ACTIVITY OF SOME NEW METAL COMPLEXES OF 2-HYDROXY BENZYLEDENE-5-(2-ACETYLOXYPHENYL)-1,3,4- THIADIAZOLE.

Journal of Al-Nahrain University-Science ◽

10.22401/jnus.11.1.04 ◽

2008 ◽

Vol 11 (1) ◽

pp. 44-49

Author(s):

Ahmed S. Majeed ◽

Keyword(s):

Biological Activity ◽

Metal Complexes ◽

Synthesis And Characterization

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New Mononuclear and Binuclear Cu(II), Co(II), Ni(II), and Zn(II) Thiosemicarbazone Complexes with Potential Biological Activity: Antimicrobial and Molecular Docking Study

Molecules ◽

10.3390/molecules26082288 ◽

2021 ◽

Vol 26 (8) ◽

pp. 2288

Author(s):

Ahmed Gaber ◽

Moamen S. Refat ◽

Arafa A.M. Belal ◽

Ibrahim M. El-Deen ◽

Nader Hassan ◽

...

Keyword(s):

Antibacterial Activity ◽

Biological Activity ◽

Molecular Docking ◽

Metal Complexes ◽

Analytical Data ◽

Docking Study ◽

Spectroscopic Techniques ◽

Molecular Docking Study ◽

Tetrahedral Geometry ◽

Thiosemicarbazone Complexes

Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+, and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity. The structure of the MTSC ligand and its metal complexes was fully characterized by elemental analysis, spectroscopic techniques (NMR, FTIR, UV-Vis), molar conductivity, thermogravimetric analysis (TG), and thermal differential analysis (DrTGA). The spectral and analytical data revealed that the obtained thiosemicarbazone-metal complexes have octahedral geometry around the metal center, except for the Zn2+-thiosemicarbazone complexes, which showed a tetrahedral geometry. The antibacterial and antifungal activities of the MTSC ligand and its (Co2+, Ni2+, Cu2+, and Zn2+) metal complexes were also investigated. Interestingly, the antibacterial activity of MTSC- metal complexes against examined bacteria was higher than that of the MTSC alone, which indicates that metal complexation improved the antibacterial activity of the parent ligand. Among different metal complexes, the MTSC- mono- and binuclear Cu2+ complexes showed significant antibacterial activity against Bacillus subtilis and Proteus vulgaris, better than that of the standard gentamycin drug. The in silico molecular docking study has revealed that the MTSC ligand could be a potential inhibitor for the oxidoreductase protein.

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