Porous cellulose acetate mixed-matrix membrane adsorbents for efficient clearance of p-cresol and creatinine from synthetic serum

Polyethersulfon (PES) membrane has been widely used in the biomedical field especially in hemodialysis application. Many modifications of membranes have been applied into hemodialysis such as diffusion, adsorption, and mixed-matrix membrane. The main problem of those membranes is less selectivity to attract the uremic toxins. In this study, we report the modification of PES mixed with cellulose acetate (PES/CA) membrane as mixed-matrix membrane (MMM) using imprinted-zeolite (PES/CA/IZC) in order to increase the selectivity for targeted analyte. The hollow fibre membranes (HFM) were fabricated by dry-wet spinning technique. The successful zeolite A synthesised and was characterised by x-ray diffraction (XRD). The mixed-matrix membranes were characterised in terms of morphology using scanning electron microscopy (SEM), water contact angle (WCA), pure water flux (PWF), clearance of creatinine (CC), and BSA adsorption. In accordance with the results of characterisation, the synthesis of zeolite A, and imprinted-zeolite creatinine was successfully fabricated. The SEM results showed that the PES/CA/IZC membrane has uniform pores and fingerlike structure. The same result was obtained for PES/CA membrane, but not for PES/CA/ZA membrane. The WCA of the PES/CA; PES/CA/ZA; and PES/CA/IZC were 85.63; 84.98; and 77.53 (o), respectively. While the PWF were 22.84; 27.57, and 40.52 (Lm-2h-1), respectively. The addition of imprinted-zeolite into the membrane improved creatinine removal up to 74.99%. It showed that PES/CA/IZC has succeeded in increasing the selectivity of membranes to attract the creatinine as target analyte. Compared to the PES/CA, the creatinine clearance of membranes improved and increased up to 5.2%. For protein rejection, the PES/CA/IZC rejected 79.05% of bovine serum albumin (BSA). Based on these results, it can be concluded that PES/CA/IZC can be considered as hemodialysis membranes.

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Effect of Polyvinyl Pyrolidone on Morphology and Performance of Cellulose Acetate Based Dialysis Membrane

Engineering, Technology & Applied Science Research ◽

10.48084/etasr.2491 ◽

2019 ◽

Vol 9 (1) ◽

pp. 3744-3749

Author(s):

H. Waheed ◽

A. Hussain

Keyword(s):

Contact Angle ◽

Cellulose Acetate ◽

Membrane Surface ◽

Pure Water ◽

Water Flux ◽

Mixed Matrix Membrane ◽

Mixed Matrix ◽

Urea Clearance ◽

And Performance ◽

Operation Phase

Polyvinyl pyrolidone (PVP) was added as filler in cellulose acetate (CA) to produce mixed matrix membrane (MMM) for hemodialysis operation. Phase separation induced by diffusion (DIPS) was used for fabrication of mixed matrix CA/PVP flat sheet membranes. The effect of adding PVP was investigated on the morphology and permeation efficiencies of CA membranes. The surface arrangement of polymer and additives in pure and blended membrane was studied by FTIR, contact angle and SEM. Results revealed homogenous and significant mixing of PVP content into pure CA matrix. Performance efficiency of blended membranes was investigated by means of pure water flux (PWF), urea clearance and % rejection of bovine serum albumin (BSA). The observable decrease of contact angle from 83° to 69° in CA/PVP MMM membranes of varying composition effectively revealed enhancement in hydrophilicity of MMM membrane surface. For protein rejection, all CA/PVP membranes rejected>90% of BSA relative to 25% for pure CA membrane. Furthermore, urea clearance behavior for CA/PVP membranes was 62.4% in comparison to 52% for pure CA membrane. The incorporation PVP i.e 1% by weight (Mpvp1) significantly improved the hydrophilicity, PWF, BSA rejection and urea clearance percentages of modified CA membrane for dialysis application.

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