Development of a Nomogram for Predicting Nasogastric Tube-Associated Pressure Injuries in Intensive Care Unit Patients

2021 ◽  
Author(s):  
Ya-Bin Zhang ◽  
Ling Gou ◽  
Ju-Hong Pei ◽  
Rui-Ling Nan ◽  
Xi-Ping Shen ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Nasogastric Tube

Plasma pharmacokinetics of bedaquiline administered by nasogastric tube in an intensive care unit

2020 ◽  
Vol 24 (1) ◽  
pp. 110-112 ◽  
Author(s):  
E. Dang ◽  
F. Sayagh ◽  
M. P. Lê ◽  
M. Neuville ◽  
F. Sinnah ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Nasogastric Tube ◽  
Multidrug Resistant ◽  
Therapeutic Drug ◽  
Tb Treatment ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Plasma Pharmacokinetics ◽  
Drug Pharmacokinetics

We present the case of a 21-year-old man admitted to the intensive care unit with multi-organ failure due to multidrug-resistant tuberculosis (TB). TB treatment initially comprised moxifloxacin, ethambutol, linezolid and amikacin administered intravenously. Due to suspected moxifloxacin-induced liver injury, we stopped all fluoroquinolones and switched to bedaquiline (BDQ), which is only available in tablets for oral administration. Since our patient had to be fed through a nasogastric tube (NGT), BDQ was administered after being crushed and dissolved in water; drug pharmacokinetics were studied using repeated blood sampling. Therapeutic drug monitoring showed that BDQ was detectable in blood plasma with a trough concentration above the supposed efficacy threshold, suggesting that this molecule could be administered through NGT.

Knotting of Nasogastric Tube Around a Nasotracheal Tube: An Unusual Cause of Hypercapnia in a 3-Month-Old Infant

2010 ◽  
Vol 19 (2) ◽  
pp. 198-197 ◽  
Author(s):  
Imad Melki ◽  
Nayla Matar ◽  
Sabine Maalouf ◽  
Simon Rassi
Keyword(s):  
Intensive Care Unit ◽  
Septic Shock ◽  
Intensive Care ◽  
Respiratory Distress ◽  
Chest Radiograph ◽  
Nasogastric Tube ◽  
Nasotracheal Tube

A 3-month-old boy was admitted to the intensive care unit because of septic shock; he required immediate intubation and placement of a nasogastric tube. A confirmatory chest radiograph showed that the nasogastric tube was looping in the hypopharynx and needed to be repositioned. During removal of the nasogastric tube, the infant experienced hypercapnia and respiratory distress. These complications were due to looping and knotting of the nasogastric tube around the nasotracheal tube.

scholarly journals Pharmacokinetics of a Clarithromycin Suspension Administered via Nasogastric Tube to Seriously Ill Patients

1999 ◽  
Vol 43 (5) ◽  
pp. 1277-1280 ◽  
Author(s):  
Douglas N. Fish ◽  
Edward Abraham
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Nasogastric Tube ◽  
Pharmacokinetic Parameters ◽  
Intrapatient Variability ◽  
Seriously Ill Patients ◽  
Hydroxylated Metabolite ◽  
Ill Adults ◽  
Seriously Ill

ABSTRACT The pharmacokinetics of clarithromycin and its 14-(R)-hydroxylated metabolite were studied on two separate occasions after nasogastric administration of 500 mg of a clarithromycin suspension to 16 seriously ill adults in an intensive care unit. The clarithromycin suspension appeared to be adequately absorbed, and the pharmacokinetics of neither clarithromycin nor 14-(R)-hydroxyclarithromycin differed significantly between the two dosing periods. No substantial differences in pharmacokinetics were observed compared to previously published studies of other adult populations. Minimal intrapatient variability of pharmacokinetic parameters was observed in these seriously ill patients.

scholarly journals Plasma Concentrations of Posaconazole Administered via Nasogastric Tube in Patients in a Surgical Intensive Care Unit

2012 ◽  
Vol 56 (8) ◽  
pp. 4468-4470 ◽  
Author(s):  
Dominic Störzinger ◽  
Stephan Borghorst ◽  
Stefan Hofer ◽  
Cornelius J. Busch ◽  
Christoph Lichtenstern ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Nasogastric Tube ◽  
High Performance ◽  
Plasma Concentrations ◽  
Volume Of Distribution ◽  
Surgical Intensive Care Unit ◽  
Surgical Intensive Care ◽  
Drug Concentrations ◽  
Apparent Clearance

ABSTRACTAbdominal surgery may affect intestinal absorption and the resulting levels of posaconazole in the blood. We measured plasma posaconazole levels in surgical intensive care unit (SICU) patients and tried to develop a predictive population pharmacokinetics model. A total of 270 samples from 15 patients receiving posaconazole via nasogastric tube were measured by high-performance liquid chromatography (HPLC). SICU patients showed lower plasma drug concentrations, a higher apparent clearance, and a higher volume of distribution than those in hematology patients, possibly due to poor absorption.

Nosocomial Pseudomonas aeruginosa Conjunctivitis in a Pediatric Hospital

1988 ◽  
Vol 9 (2) ◽  
pp. 77-80 ◽  
Author(s):  
Susan King ◽  
Shashi P. Devi ◽  
Cathy Mindorff ◽  
Mary Lou Patrick ◽  
Ronald Gold ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Pseudomonas Aeruginosa ◽  
Intensive Care ◽  
Nasogastric Tube ◽  
Neonatal Intensive Care ◽  
Pediatric Intensive Care ◽  
Respiratory Care ◽  
Age Group ◽  
Pediatric Hospital ◽  
Eye Care

AbstractConjunctivitis accounted for 5% of nosocomial infections occurring in a university-affiliated pediatric hospital between January 1984 and April 1986. Pseudomonas aeruginosa was recovered from the conjunctiva of 30 patients. The primary diseases of these patients were chronic and debilitating. Eighty percent of patients were under 18 months of age although only 30% of admissions are represented in this age group. Seventy percent of cases occurred in pediatric intensive care unit/neonatal intensive care unit patients. Seventy percent of patients who had antecedent nasopharyngeal/ endotracheal cultures obtained were colonized with P aeruginosa. All patients except one had one or more of the following interventions prior to the onset of conjunctivitis: tracheostomy, endotracheal tube, oxygen by hood, or suctioning. Two children (7.4%) have residual corneal scars. Improvements in eye care including protection of the eye during suctioning, other respiratory care, and nasogastric tube procedures are warranted.

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