Simvastatin Induces Apoptosis in Castrate Resistant Prostate Cancer Cells by Deregulating Nuclear Factor-κB Pathway

2013 ◽  
Vol 189 (4) ◽  
pp. 1547-1552 ◽  
Author(s):  
Yong Hyun Park ◽  
Su Yeon Seo ◽  
Eunhye Lee ◽  
Ja Hyeon Ku ◽  
Hyeon Hoe Kim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Prostate Cancer Cells ◽  
Castrate Resistant Prostate Cancer ◽  
Castrate Resistant

scholarly journals Retigeric Acid B Exhibits Antitumor Activity through Suppression of Nuclear Factor-κB Signaling in Prostate Cancer Cells in Vitro and in Vivo

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e38000 ◽  
Author(s):  
Yong-Qing Liu ◽  
Xiao-Yan Hu ◽  
Tao Lu ◽  
Yan-Na Cheng ◽  
Charles Y. F. Young ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Antitumor Activity ◽  
Cancer Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Prostate Cancer Cells

Nucleoporin 62 and Ca2+ /calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells

The Prostate ◽  
2015 ◽  
Vol 76 (3) ◽  
pp. 294-306 ◽  
Author(s):  
Loukia G. Karacosta ◽  
Laura A. Kuroski ◽  
Wilma A. Hofmann ◽  
Gissou Azabdaftari ◽  
Michalis Mastri ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Receptor Activity ◽  
Prostate Cancer Cells ◽  
Androgen Receptor Activity ◽  
Castrate Resistant Prostate Cancer ◽  
Castrate Resistant

Progressive dysregulation of transcription factors NF-κB and STAT1 in prostate cancer cells causes proangiogenic production of CXC chemokines

2004 ◽  
Vol 286 (4) ◽  
pp. C840-C847 ◽  
Author(s):  
Hui Shen ◽  
Alex B. Lentsch
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Prostate Cancer Cells ◽  
Normal Prostate ◽  
Cxc Chemokine ◽  
Growth Production ◽  
Chemokine Family ◽  
Transcription Factor Nuclear Factor

The CXC chemokine family includes members that possess angiogenic and angiostatic properties. Angiogenic CXC chemokines are produced by prostate cancer cells and contribute to prostate tumor growth. Production of angiostatic CXC chemokines by prostatic cells has not been previously studied. Here we show that normal prostate epithelial (PZ-HPV-7) cells produce low amounts of angiogenic CXC chemokines, whereas prostate cancer cells from primary (CA-HPV-10) and metastatic (PC-3) tumors produce progressively greater amounts. These effects were caused by progressive increases in activation of the transcription factor nuclear factor-κB in prostate cancer cells. Conversely, PZ-HPV-7 cells produced relatively high levels of angiostatic CXC chemokines, whereas CA-HPV-10 and PC-3 cells produced stepwise lower amounts. These effects were dependent on reduced activation of signal transduction and activator of transcription 1 (STAT1) in prostate cancer cells. These data suggest that there is progressive dysregulation of nuclear factor-κB and STAT1 in prostate cancer cells that leads to proangiogenic production of CXC chemokines.

scholarly journals The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-κB inhibition and enhanced by the presence of PTEN

2007 ◽  
Vol 6 (9) ◽  
pp. 2477-2486 ◽  
Author(s):  
Yulan Sun ◽  
Daret K. St. Clair ◽  
Fang Fang ◽  
Graham W. Warren ◽  
Vivek M. Rangnekar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Prostate Cancer Cells
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