Electrical Stimulation of Somatic Afferent Nerves in the Foot Increases Bladder Capacity in Healthy Human Subjects

We previously found that the greatest salivation response in healthy human subjects is produced by facial vibrotactile stimulation of 89 Hz frequency with 1.9 μm amplitude (89 Hz-S), as reported by Hiraba et al. (2012, 20011, and 2008). We assessed relationships between the blood flow to brain via functional near-infrared spectroscopy (fNIRS) in the frontal cortex and autonomic parameters. We used the heart rate (HRV: heart rate variability analysis in RR intervals), pupil reflex, and salivation as parameters, but the interrelation between each parameter and fNIRS measures remains unknown. We were to investigate the relationship in response to established paradigms using simultaneously each parameter-fNIRS recording in healthy human subjects. Analysis of fNIRS was examined by a comparison of various values between before and after various stimuli (89 Hz-S, 114 Hz-S, listen to classic music, and “Ahh” vocalization). We confirmed that vibrotactile stimulation (89 Hz) of the parotid glands led to the greatest salivation, greatest increase in heart rate variability, and the most constricted pupils. Furthermore, there were almost no detectable differences between fNIRS during 89 Hz-S and fNIRS during listening to classical music of fans. Thus, vibrotactile stimulation of 89 Hz seems to evoke parasympathetic activity.

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CLINICAL STUDIES OF "BIG ACTH": ITS PHYSICO-CHEMICAL CHARACTERISTICS

Acta Endocrinologica ◽

10.1530/acta.0.0890221 ◽

1978 ◽

Vol 89 (2) ◽

pp. 221-231 ◽

Cited By ~ 5

Author(s):

Yukio Yamada ◽

Seiki Ito ◽

Masahiro Miyashita ◽

Kenzo Kaneko ◽

Toru Watanabe ◽

...

Keyword(s):

Human Subjects ◽

Gel Filtration ◽

Disc Electrophoresis ◽

Plasma Samples ◽

Acth Secretion ◽

Healthy Human ◽

Physico Chemical ◽

Healthy Human Subjects ◽

Pituitary Glands ◽

Stimulation Of

ABSTRACT The big ACTH fractions available from human plasma and pituitary glands and from porcine pituitary glands were physico-chemically characterized by gel filtration, disc electrophoresis and isoelectric separation. In the case of healthy human subjects, big ACTH fractions were isolated by gel filtration from plasma samples taken during states of acute ACTH hypersecretion such as the lysine-8-vasopressin, insulin or metopyrone tests though none of these fractions were isolated from plasma sampled under normal conditions. Even with no stimulation of ACTH secretion, patients with Cushing's disease gave plasma samples that contained an isolable big ACTH fraction, but such a fraction was hardly isolated from plasma taken from patient with Addison's disease. Both human pituitaries and porcine pituitaries contained an isolable big ACTH fraction. By a gel filtration analysis the molecular weight of the big ACTH was estimated to be higher than 20 000. Disc electrophoresis with an acrylamide gel indicated that big ACTH is strongly basic while small ACTH is more acidic than pH 8.3. Isoelectric separation revealed that the isoelectric point of human big ACTH is higher than pH 10.0 while that of small ACTH is about pH 6.8.

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Ethanol effects on naloxone-induced stimulation of the hypothalamic-pituitary system in healthy human subjects

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2004-832901 ◽

2004 ◽

Vol 112 (08) ◽

Author(s):

U Zimmermann ◽

B Steffin ◽

K Spring ◽

M Uhr ◽

S O'Connor ◽

...

Keyword(s):

Human Subjects ◽

Healthy Human ◽

Healthy Human Subjects ◽

Stimulation Of

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Comparison of human vocal cord movements during isocapnic hypoxia and hypercapnia

Journal of Applied Physiology ◽

10.1152/jappl.1982.53.1.81 ◽

1982 ◽

Vol 53 (1) ◽

pp. 81-86 ◽

Cited By ~ 18

Author(s):

S. J. England ◽

D. Bartlett ◽

S. L. Knuth

Keyword(s):

Vocal Cord ◽

Human Subjects ◽

Healthy Human ◽

Peripheral Chemoreceptors ◽

Airflow Resistance ◽

Air Breathing ◽

Healthy Human Subjects ◽

Laryngeal Resistance ◽

Stimulation Of

Respiratory vocal cord movements were analyzed in healthy human subjects during air breathing and in isocapnic hypoxia and hypercapnia. In the majority of experiments, expiratory glottic narrowing was substantially greater during hypoxia than during hypercapnia. Because ventilations were carefully matched under these two conditions, it is concluded that hypoxic stimulation of peripheral chemoreceptors favors expiratory glottic narrowing and leads to a relatively high laryngeal airflow resistance. In contrast, hypercapnia is accompanied by low expiratory laryngeal resistance. Similar rates of expiratory airflow with these two stimuli must be achieved by different balances of the factors that determine this flow.

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DNN-Based FES Control for Gait Rehabilitation of Hemiplegic Patients

Applied Sciences ◽

10.3390/app11073163 ◽

2021 ◽

Vol 11 (7) ◽

pp. 3163

Author(s):

Suhun Jung ◽

Jae Hwan Bong ◽

Seung-Jong Kim ◽

Shinsuk Park

Keyword(s):

Electrical Stimulation ◽

Control Algorithm ◽

Deep Neural Networks ◽

Control Method ◽

Human Subjects ◽

Gait Rehabilitation ◽

Healthy Human ◽

Activity Data ◽

Paretic Side ◽

Stimulation Of

In this study, we proposed a novel machine-learning-based functional electrical stimulation (FES) control algorithm to enhance gait rehabilitation in post-stroke hemiplegic patients. The electrical stimulation of the muscles on the paretic side was controlled via deep neural networks, which were trained using muscle activity data from healthy people during gait. The performance of the developed system in comparison with that of a conventional FES control method was tested with healthy human subjects.

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