Facial Vibrotactile Stimulation Activates the Parasympathetic Nervous System: Study of Salivary Secretion, Heart Rate, Pupillary Reflex, and Functional Near-Infrared Spectroscopy Activity

We previously found that the greatest salivation response in healthy human subjects is produced by facial vibrotactile stimulation of 89 Hz frequency with 1.9 μm amplitude (89 Hz-S), as reported by Hiraba et al. (2012, 20011, and 2008). We assessed relationships between the blood flow to brain via functional near-infrared spectroscopy (fNIRS) in the frontal cortex and autonomic parameters. We used the heart rate (HRV: heart rate variability analysis in RR intervals), pupil reflex, and salivation as parameters, but the interrelation between each parameter and fNIRS measures remains unknown. We were to investigate the relationship in response to established paradigms using simultaneously each parameter-fNIRS recording in healthy human subjects. Analysis of fNIRS was examined by a comparison of various values between before and after various stimuli (89 Hz-S, 114 Hz-S, listen to classic music, and “Ahh” vocalization). We confirmed that vibrotactile stimulation (89 Hz) of the parotid glands led to the greatest salivation, greatest increase in heart rate variability, and the most constricted pupils. Furthermore, there were almost no detectable differences between fNIRS during 89 Hz-S and fNIRS during listening to classical music of fans. Thus, vibrotactile stimulation of 89 Hz seems to evoke parasympathetic activity.

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Effects of water ingestion on gastric electrical activity and heart-rate variability in healthy human subjects

Journal of the Autonomic Nervous System ◽

10.1016/0165-1838(95)00110-7 ◽

1996 ◽

Vol 58 (1-2) ◽

pp. 44-50 ◽

Cited By ~ 16

Author(s):

Michio Watanabe ◽

Yutaka Shimada ◽

Shinya Sakai ◽

Naotoshi Shibahara ◽

Harumi Matsuda ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Electrical Activity ◽

Human Subjects ◽

Gastric Electrical Activity ◽

Healthy Human ◽

Water Ingestion ◽

Healthy Human Subjects

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Comparative study of heart rate variability between healthy human subjects and healthy dogs, rabbits and calves

Laboratory Animals ◽

10.1258/la.2007.007085 ◽

2009 ◽

Vol 43 (1) ◽

pp. 41-45 ◽

Cited By ~ 22

Author(s):

A Manzo ◽

Y Ootaki ◽

C Ootaki ◽

K Kamohara ◽

K Fukamachi

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Comparative Study ◽

Human Subjects ◽

Healthy Human ◽

Healthy Human Subjects ◽

Healthy Dogs

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Frequency-resolved analysis of coherent oscillations of local cerebral blood volume, measured with near-infrared spectroscopy, and systemic arterial pressure in healthy human subjects

PLoS ONE ◽

10.1371/journal.pone.0211710 ◽

2019 ◽

Vol 14 (2) ◽

pp. e0211710 ◽

Cited By ~ 6

Author(s):

Kristen Tgavalekos ◽

Thao Pham ◽

Nishanth Krishnamurthy ◽

Angelo Sassaroli ◽

Sergio Fantini

Keyword(s):

Infrared Spectroscopy ◽

Arterial Pressure ◽

Blood Volume ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Cerebral Blood Volume ◽

Human Subjects ◽

Systemic Arterial Pressure ◽

Healthy Human ◽

Healthy Human Subjects

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Homeopathic effect on heart rate variability

British Homeopathic Journal ◽

10.1054/homp.1999.0294 ◽

1999 ◽

Vol 88 (03) ◽

pp. 106-111 ◽

Cited By ~ 6

Author(s):

G Ruiz ◽

J-L Torres ◽

O Michel ◽

R Navarro

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Power Spectrum ◽

Human Subjects ◽

Healthy Human ◽

Energy Fraction ◽

High Frequencies ◽

Materia Medica ◽

Healthy Human Subjects

AbstractWe record ECGs from healthy human subjects during 24-h long intervals, using ambulatory equipment. We calculate from the data various parameters, searching for those that change in a clear and systematic way under a homoepathic stimulus, (Strophantus hispidus 30 c). The energy fraction at high frequencies in the power spectrum of heart rate variability fulfills this condition, and we are able to interpret our results in a way consistent with the information on this medicine in the homeopathic Materia Medica.

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Heart rate variability and baroreflex sensitivity are reduced in chronically undernourished, but otherwise healthy, human subjects

Clinical Science ◽

10.1042/cs20020294 ◽

2003 ◽

Vol 104 (3) ◽

pp. 295 ◽

Cited By ~ 3

Author(s):

Mario VAZ ◽

A. V. BHARATHI ◽

S. SUCHARITA ◽

D. NAZARETH

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Baroreflex Sensitivity ◽

Human Subjects ◽

Healthy Human ◽

Healthy Human Subjects

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Heart rate variability and baroreflex sensitivity are reduced in chronically undernourished, but otherwise healthy, human subjects

Clinical Science ◽

10.1042/cs1040295 ◽

2003 ◽

Vol 104 (3) ◽

pp. 295-302 ◽

Cited By ~ 4

Author(s):

Mario VAZ ◽

A.V. BHARATHI ◽

S. SUCHARITA ◽

D. NAZARETH

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

High Frequency ◽

Baroreflex Sensitivity ◽

Human Subjects ◽

Normal Weight ◽

Autonomic Nerve ◽

Total Power ◽

Healthy Human ◽

Frequency Power

Alterations in autonomic nerve activity in subjects in a chronically undernourished state have been proposed, but have been inadequately documented. The present study evaluated heart rate and systolic blood pressure variability in the frequency domain in two underweight groups, one of which was undernourished and recruited from the lower socio-economic strata [underweight, undernourished (UW/UN); n = 15], while the other was from a high class of socio-economic background [underweight, well nourished (UW/WN); n = 17], as well as in normal-weight controls [normal weight, well nourished (NW/WN); n = 27]. Baroreflex sensitivity, which is a determinant of heart rate variability, was also assessed. The data indicate that total power (0–0.4Hz), low-frequency power (0.04–0.15Hz) and high-frequency power (0.15–0.4Hz) of RR interval variability were significantly lower in the UW/UN subjects (P<0.05) than in the NW/WN controls when expressed in absolute units, but not when the low- and high-frequency components were normalized for total power. Baroreflex sensitivity was similarly lower in the UW/UN group (P<0.05). Heart rate variability parameters in the UW/WN group were generally between those of the UW/UN and NW/WN groups, but were not statistically different from either. The mechanisms that contribute to the observed differences between undernourished and normal-weight groups, and the implications of these differences, remain to be elucidated.

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