MP19-05 HEME OXYGENASE-1 PROSTATIC LEVELS ARE SIGNIFICANTLY LOWER IN PATIENTS AFFECTED BY MODERATE-SEVERE LUTS SECONDARY TO BENIGN PROSTATIC HYPERPLASIA: A PILOT STUDY

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Giorgio Ivan Russo ◽  
Luca Vanella ◽  
Sebastiano Cimino ◽  
Daniele Campisi ◽  
Eugenia Fragalà ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Pilot Study ◽  
Heme Oxygenase ◽  
Prostatic Hyperplasia ◽  
Heme Oxygenase 1

Effect of Short-term Dutasteride Therapy on Prostate Vascularity in Patients With Benign Prostatic Hyperplasia: A Pilot Study

Urology ◽  
2009 ◽  
Vol 73 (6) ◽  
pp. 1274-1278 ◽  
Author(s):  
Sergey Kravchick ◽  
Shmuel Cytron ◽  
Alla Mamonov ◽  
Ronit Peled ◽  
Lina Linov
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Pilot Study ◽  
Prostatic Hyperplasia ◽  
Short Term

Heme oxygenase levels and metaflammation in benign prostatic hyperplasia patients

2015 ◽  
Vol 34 (8) ◽  
pp. 1183-1192 ◽  
Author(s):  
Giorgio Ivan Russo ◽  
Luca Vanella ◽  
Tommaso Castelli ◽  
Sebastiano Cimino ◽  
Giulio Reale ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Heme Oxygenase ◽  
Prostatic Hyperplasia

Correlation Between Lipid Profile and Heme Oxygenase System in Patients With Benign Prostatic Hyperplasia

Urology ◽  
2014 ◽  
Vol 83 (6) ◽  
pp. 1444.e7-1444.e13 ◽  
Author(s):  
Luca Vanella ◽  
Giorgio Ivan Russo ◽  
Sebastiano Cimino ◽  
Eugenia Fragalà ◽  
Vincenzo Favilla ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Lipid Profile ◽  
Heme Oxygenase ◽  
Prostatic Hyperplasia

scholarly journals An Investigation into the Impact of a Glutaminase Inhibitor, Compound 968, on Nrf2 Signaling

2021 ◽  
Vol 1 (1) ◽  
pp. 41-47
Author(s):  
Wei Lei ◽  
Valentin M. Kliebe ◽  
Xin Chen
Keyword(s):  
Molecular Docking ◽  
Pilot Study ◽  
Neurodegenerative Diseases ◽  
Heme Oxygenase ◽  
Pathological Process ◽  
Luciferase Assay ◽  
Heme Oxygenase 1 ◽  
Nrf2 Activation ◽  
Energy Synthesis ◽  
The Impact

Glutaminase is a critical enzyme that catalyzes the process of glutaminolysis for energy synthesis. Meanwhile, glutaminase also contributes to the pathological process of various diseases, such as cancer, neurodegenerative diseases, and inflammation. This leads to the discovery of glutaminase inhibitors for therapeutical uses. However, the mechanisms of the beneficial therapeutical effect of glutaminase inhibitors are still unclear. This pilot study aimed to determine the impact of a well-characterized glutaminase inhibitor, compound 968 (C968), on Nrf2 signaling. We performed molecular docking, luciferase assay, and quantitative PCR to determine the activation of Nrf2 and the expression of several Nrf2-related genes. These experiments found that C968 induced the Nrf2 activation and promoted the expression of Nrf2, heme oxygenase-1 (HO-1), and NAD(P)H Quinone Dehydrogenase-1 (NQO-1). All findings provide evidence that Nrf2 activation could be one of the mechanisms contributing to the therapeutical activity of C968, but more studies are warranted to further confirm this mechanism.

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