MP31-12 MOLECULAR IMAGING OF DENDRITIC CELL TRAFFICKING IN VIVO IN A MURINE PROSTATE CANCER MODEL

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Albert Petrossian ◽  
Sam Robinson ◽  
Ekaterine Goliadze ◽  
Georgi Guruli
Keyword(s):  
Prostate Cancer ◽  
Dendritic Cell ◽  
Molecular Imaging ◽  
Cell Trafficking ◽  
Cancer Model ◽  
Dendritic Cell Trafficking ◽  
Prostate Cancer Model

Vitamin D3-mediated alterations to myeloid dendritic cell trafficking in vivo expand the scope of their antigen presenting properties

Vaccine ◽  
2007 ◽  
Vol 25 (7) ◽  
pp. 1236-1249 ◽  
Author(s):  
Elena Y. Enioutina ◽  
Diana Bareyan ◽  
Raymond A. Daynes
Keyword(s):  
Dendritic Cell ◽  
Vitamin D3 ◽  
Cell Trafficking ◽  
Myeloid Dendritic Cell ◽  
Antigen Presenting ◽  
Dendritic Cell Trafficking

Role of Vitamin D3 as a Sensitizer to Cryoablation in a Murine Prostate Cancer Model: Preliminary In Vivo Study

Urology ◽  
2010 ◽  
Vol 76 (3) ◽  
pp. 764.e14-764.e20 ◽  
Author(s):  
Masaki Kimura ◽  
Zahid Rabbani ◽  
Vladimir Mouraviev ◽  
Matvey Tsivian ◽  
Jorge Caso ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D3 ◽  
In Vivo Study ◽  
Cancer Model ◽  
Prostate Cancer Model

In-vivo metabolic characterization of healthy prostate and orthotopic prostate cancer in rats using proton magnetic resonance spectroscopy at 4.7 T

2013 ◽  
Vol 54 (1) ◽  
pp. 121-126
Author(s):  
Paul Walker ◽  
Peggy Provent ◽  
Xavier Tizon ◽  
Gilles Créhange ◽  
Olivier Duchamp ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Magnetic Resonance ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Human Prostate Cancer ◽  
Cancer Model ◽  
Anti Cancer ◽  
Prostate Cancer Model

Background To assist the development of new anti-cancer drugs, it is important to identify biomarkers of treatment efficacy in the preclinical phases of drug development. In order to improve the predictivity of preclinical experiments, more realistic animal models are needed, for example, tumors xenografted directly on the prostate gland of rodents. Purpose To characterize the in-vivo metabolism of healthy rat prostate and of an orthotopic human prostate cancer model using proton magnetic resonance spectroscopy (MRS). Material and Methods The highly metastatic and hormone-independent PC3-MM2 human prostate cancer model was implanted into the ventral prostate lobe of three Nude rats. Healthy Nude (n = 6) and Sprague-Dawley (n = 6) rats were also studied for interspecies comparison of normal prostate metabolism. Magnetic resonance imaging and short echo-time (TE 11.2 ms) single voxel PRESS spectroscopy were performed on dorsal (DP) and ventral (VP) prostate as well as tumor at 4.7 T. The metabolic content and volume of dorsal and ventral lobes were characterized as a function of species and age. Results Slightly lower total creatine (tCr)/water (11.3±2.6 vs. 15.3±3.0, NS), but significantly higher Inositol (Ins)/water (18.9±1.9 vs. 6.6±3.3, P < 0.003) and total choline (tCho)/water (15.0±2.1 vs. 5.6±1.1, P< 0.00007) were observed within healthy DP lobes with respect to VP lobes. No significant variation in metabolic content was seen in healthy DP and VP lobes of Nude rats as a function of age, and no species dependence was observed in their metabolic content. For the orthotopic PC3-MM2 tumor, implanted in VP, the tCr/water ratio was significantly lower (3.1±0.9) than neighboring DP (12.8±1.8, P < 0.00003) and healthy VP (15.3±3.0, P < 0.00006). For Ins, the metabolite ratio in PC3-MM2 was close to that of healthy VP (4.3±2.8 vs. 6.6±3.3, p = NS), but much lower than in neighboring DP (19.1±1.3, P < 0.00005). A similar trend was also observed for tCho, where metabolite ratios in PC3-MM2, healthy VP and neighboring DP were 3.5±0.9, 5.6±1.1, and 15.9±0.8, respectively. Conclusion The in-vivo MRS study of healthy prostate and orthotopic prostate cancer is feasible in rats. Such baseline data could be important when following the modifications in metabolism, including during anti-cancer drug development protocols or following radiotherapy.

The Sphingosine-1-Phosphate Receptor Agonist FTY720 Modulates Dendritic Cell Trafficking In Vivo

2005 ◽  
Vol 5 (11) ◽  
pp. 2649-2659 ◽  
Author(s):  
Yuk Yuen Lan ◽  
An De Creus ◽  
Bridget L. Colvin ◽  
Masanori Abe ◽  
Volker Brinkmann ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Receptor Agonist ◽  
Cell Trafficking ◽  
Sphingosine 1 Phosphate ◽  
Dendritic Cell Trafficking

scholarly journals Pre-conditioning cryosurgery: Cellular and molecular mechanisms and dynamics of TNF-α enhanced cryotherapy in an in vivo prostate cancer model system

Cryobiology ◽  
2010 ◽  
Vol 61 (3) ◽  
pp. 280-288 ◽  
Author(s):  
Jing Jiang ◽  
Raghav Goel ◽  
Stephen Schmechel ◽  
Gregory Vercellotti ◽  
Colleen Forster ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Mechanisms ◽  
Model System ◽  
Cancer Model ◽  
Tnf Α ◽  
Prostate Cancer Model

scholarly journals Enhanced anti-tumor efficacy and mechanisms associated with docetaxel-piperine combination- in vitro and in vivo investigation using a taxane-resistant prostate cancer model

Oncotarget ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 3338-3352 ◽  
Author(s):  
Chenrui Li ◽  
Zhijun Wang ◽  
Qian Wang ◽  
Rebecca Lucinda Ka Yan Ho ◽  
Ying Huang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Model ◽  
Prostate Cancer Model

scholarly journals Ultrasound-Guided Delivery of siRNA and a Chemotherapeutic Drug by Using Microbubble Complexes: In Vitro and In Vivo Evaluations in a Prostate Cancer Model

2016 ◽  
Vol 17 (4) ◽  
pp. 497 ◽  
Author(s):  
Yun Jung Bae ◽  
Young Il Yoon ◽  
Tae-Jong Yoon ◽  
Hak Jong Lee
Keyword(s):  
Prostate Cancer ◽  
Chemotherapeutic Drug ◽  
Cancer Model ◽  
Ultrasound Guided ◽  
Prostate Cancer Model

Abstract 1795: Darolutamide demonstrates greater in vivo activity than enzalutamide in prostate cancer model with therapy-resistant androgen receptor mutation

2018 ◽  
Author(s):  
Bernard Haendler ◽  
Tatsuo Sugawara ◽  
Simon J. Baumgart ◽  
Pascale Lejeune
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Model ◽  
Prostate Cancer Model
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