MP20-10 A BIOSENSOR FOR RAPID AND SIMULTANEOUS UROPATHOGEN IDENTIFICATION AND CIPROFLOXACIN MINIMUM INHIBITORY CONCENTRATION DETERMINATION

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Emanuela Altobelli ◽  
Ruchika Mohan ◽  
Kathleen Mach ◽  
Mandy La Yi Sin ◽  
Victoria Anikst ◽  
...  
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Inhibitory Concentration ◽  
Concentration Determination

Assembly and antifungal effect of a new fluconazole-carrier nanosystem

2020 ◽  
Vol 15 (4) ◽  
pp. 273-285 ◽  
Author(s):  
Taynara MT de Lima ◽  
Laís S Arias ◽  
Letícia F Afanaci ◽  
Raphael FB Ferraresse ◽  
Francisco N de S Neto ◽  
...  
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Candida Glabrata ◽  
Inhibitory Concentration ◽  
Fungal Infections ◽  
Oxide Nanoparticles ◽  
Total Biomass ◽  
Planktonic Cells ◽  
Antifungal Effect ◽  
Concentration Determination ◽  
Antifungal Effects

Aim: To assemble, characterize and assess the antifungal effects of a new fluconazole (FLZ)-carrier nanosystem. Materials & methods: The nanosystem was prepared by loading FLZ on chitosan (CS)-coated iron oxide nanoparticles (IONPs). Antifungal effects were evaluated on planktonic cells (by minimum inhibitory concentration determination) and on biofilms (by quantification of cultivable cells, total biomass, metabolism and extracellular matrix) of Candida albicans and Candida glabrata. Results: Characterization results ratified the formation of a nanosystem (<320 nm) with FLZ successfully embedded. IONPs-CS-FLZ nanosystem reduced minimum inhibitory concentration values and, in general, showed similar antibiofilm effects compared with FLZ alone. Conclusion: IONPs-CS-FLZ nanosystem was more effective than FLZ mainly in inhibiting Candida planktonic cells. This nanocarrier has potential to fight fungal infections.

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